Variables affecting darbepoetin resistance index in hemodialysis patients
Erythropoietin resistance index calculation has been used as a tool to evaluate anemia response to erythropoietin therapy. Very little has been reported in its use when using darbepoetin and factors influencing in Arab patients. Darbepoetin resistance index (DRI) was calculated in all our patients u...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2017-01-01
|
Series: | Saudi Journal of Kidney Diseases and Transplantation |
Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2017;volume=28;issue=4;spage=737;epage=742;aulast=Hejaili |
id |
doaj-1af9d219356a437198ebce9869330d8c |
---|---|
record_format |
Article |
spelling |
doaj-1af9d219356a437198ebce9869330d8c2020-11-24T23:05:52ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422017-01-01284737742Variables affecting darbepoetin resistance index in hemodialysis patientsFayez HejailiEhtsham HafeezBurhan BhuttoLulwa Al TurkiAbdul Kareem AlsuwidaHammad RazaAbdulla Al-SayyariErythropoietin resistance index calculation has been used as a tool to evaluate anemia response to erythropoietin therapy. Very little has been reported in its use when using darbepoetin and factors influencing in Arab patients. Darbepoetin resistance index (DRI) was calculated in all our patients using darbepoetin. This was correlated to demographic, clinical, and laboratory parameters. Of the 250 patients, 40.4% were diabetic, 71.1% on hemodialysis, and 28.6% on hemodiafiltration), 23.9% with PermCaths (PC), and 76.1 % with arteriovenous fistula (AVF). The mean DRI was 10.96 ± 12.9 I. Females had 45% higher DRI than males (P = 0.005), and patients with PC had a 66% higher DRI than those with AVF (P = 0.029). Patients with Vitamin D level below the 50th percentile had 55.9% higher DRI than those above it (P = 0.05). DRI was negatively correlated with age (P = 0.018), dialysis vintage (P = 0.039), interdialytic weight gain P = 0.007), Vitamin D level, and serum albumin (P = 0.005) and positively correlate with parathyroid hormone (PTH) level (P = 0.000). No impact was seen by the mode of dialysis, being diabetic, using anti-hypertensive therapy, body mass index, Kt/V, serum iron, total iron binding capacity, transferrin saturation, ferritin, C-reactive protein, Ca, or P. DRI in our Arab patients was comparable to erythropoietin resistance indices reported in other communities. Higher DRI was observed in females, PC users, lower serum albumin, lower Vitamin D, and shorter dialysis vintage. A negative correlation existed between DRI and age, dialysis vintage, interdialytic weight, and serum albumin and a positive correlation with PTH level.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2017;volume=28;issue=4;spage=737;epage=742;aulast=Hejaili |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fayez Hejaili Ehtsham Hafeez Burhan Bhutto Lulwa Al Turki Abdul Kareem Alsuwida Hammad Raza Abdulla Al-Sayyari |
spellingShingle |
Fayez Hejaili Ehtsham Hafeez Burhan Bhutto Lulwa Al Turki Abdul Kareem Alsuwida Hammad Raza Abdulla Al-Sayyari Variables affecting darbepoetin resistance index in hemodialysis patients Saudi Journal of Kidney Diseases and Transplantation |
author_facet |
Fayez Hejaili Ehtsham Hafeez Burhan Bhutto Lulwa Al Turki Abdul Kareem Alsuwida Hammad Raza Abdulla Al-Sayyari |
author_sort |
Fayez Hejaili |
title |
Variables affecting darbepoetin resistance index in hemodialysis patients |
title_short |
Variables affecting darbepoetin resistance index in hemodialysis patients |
title_full |
Variables affecting darbepoetin resistance index in hemodialysis patients |
title_fullStr |
Variables affecting darbepoetin resistance index in hemodialysis patients |
title_full_unstemmed |
Variables affecting darbepoetin resistance index in hemodialysis patients |
title_sort |
variables affecting darbepoetin resistance index in hemodialysis patients |
publisher |
Wolters Kluwer Medknow Publications |
series |
Saudi Journal of Kidney Diseases and Transplantation |
issn |
1319-2442 |
publishDate |
2017-01-01 |
description |
Erythropoietin resistance index calculation has been used as a tool to evaluate anemia response to erythropoietin therapy. Very little has been reported in its use when using darbepoetin and factors influencing in Arab patients. Darbepoetin resistance index (DRI) was calculated in all our patients using darbepoetin. This was correlated to demographic, clinical, and laboratory parameters. Of the 250 patients, 40.4% were diabetic, 71.1% on hemodialysis, and 28.6% on hemodiafiltration), 23.9% with PermCaths (PC), and 76.1 % with arteriovenous fistula (AVF). The mean DRI was 10.96 ± 12.9 I. Females had 45% higher DRI than males (P = 0.005), and patients with PC had a 66% higher DRI than those with AVF (P = 0.029). Patients with Vitamin D level below the 50th percentile had 55.9% higher DRI than those above it (P = 0.05). DRI was negatively correlated with age (P = 0.018), dialysis vintage (P = 0.039), interdialytic weight gain P = 0.007), Vitamin D level, and serum albumin (P = 0.005) and positively correlate with parathyroid hormone (PTH) level (P = 0.000). No impact was seen by the mode of dialysis, being diabetic, using anti-hypertensive therapy, body mass index, Kt/V, serum iron, total iron binding capacity, transferrin saturation, ferritin, C-reactive protein, Ca, or P. DRI in our Arab patients was comparable to erythropoietin resistance indices reported in other communities. Higher DRI was observed in females, PC users, lower serum albumin, lower Vitamin D, and shorter dialysis vintage. A negative correlation existed between DRI and age, dialysis vintage, interdialytic weight, and serum albumin and a positive correlation with PTH level. |
url |
http://www.sjkdt.org/article.asp?issn=1319-2442;year=2017;volume=28;issue=4;spage=737;epage=742;aulast=Hejaili |
work_keys_str_mv |
AT fayezhejaili variablesaffectingdarbepoetinresistanceindexinhemodialysispatients AT ehtshamhafeez variablesaffectingdarbepoetinresistanceindexinhemodialysispatients AT burhanbhutto variablesaffectingdarbepoetinresistanceindexinhemodialysispatients AT lulwaalturki variablesaffectingdarbepoetinresistanceindexinhemodialysispatients AT abdulkareemalsuwida variablesaffectingdarbepoetinresistanceindexinhemodialysispatients AT hammadraza variablesaffectingdarbepoetinresistanceindexinhemodialysispatients AT abdullaalsayyari variablesaffectingdarbepoetinresistanceindexinhemodialysispatients |
_version_ |
1725625280063602688 |