Creatinine to Body Weight Ratio Is Associated with Incident Diabetes: Population-Based Cohort Study

• Main Authors: Yoshitaka Hashimoto, Takuro Okamura, Masahide Hamaguchi, Akihiro Obora, Takao Kojima, Michiaki Fukui
• Format: Article
• Language: English
• Published: MDPI AG 2020-01-01
• Series: Journal of Clinical Medicine
• Subjects: creatinine; diabetes; epidemiology; muscle mass; skeletal muscle mass
• Online Access: https://www.mdpi.com/2077-0383/9/1/227
• ISSN: 2077-0383

We investigated the association between creatinine to body weight (Cre/BW) ratio and incident diabetes. In this cohort study, 9659 men and 7417 women were follow up mean (SD) 5.6 (3.5) years and 5.4 (3.4) years, respectively. For men, tertile 1 (T1; n = 3176), Cre/BW &lt; 0.01275; tertile 2 (T2; n = 3258), 0.01275 &#8804; Cre/BW &lt; 0.0148; and tertile 3 (T3; n = 3225), Cre/BW &#8805; 0.0148; and for women, T1 (n = 2437), Cre/BMI &lt; 0.0118; T2 (n = 2516), 0.0118 &#8804; Cre/BMI &lt; 0.014; and T3 (n = 2477), Cre/BMI &#8805; 0.014. Among them, 362 men and 102 women developed diabetes. The hazard ratios (HRs) of incident diabetes in the T2 group was 0.56 (95% CI 0.44&#8722;0.71, <i>p</i> &lt; 0.001) in men and 0.61 (0.38&#8722;0.99, <i>p</i> = 0.045) in women and in the T3 group was 0.42 (0.32&#8722;0.54, <i>p</i> &lt; 0.001) in men and 0.55 (0.34&#8722;0.89, <i>p</i> = 0.014) in women after adjusting for covariates, compared with the T1 group. Moreover, &#916;0.001 incremental of Cre/BW is negatively associated with incident diabetes (adjusted HR 0.84, 95% CI 0.80&#8722;0.88, <i>p</i> &lt; 0.001 for men and 0.88, 0.81&#8722;0.96, <i>p</i> = 0.003 for women). In conclusion, Cre/BW ratio is inversely related to incident diabetes. Checking Cre/BW ratios may predict future diabetes risks.