Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)

RAS mutation analysis is an important companion diagnostic test. Treatment of colorectal cancer with anti-Epidermal Growth Factor Receptor (EGFR) therapy requires demonstration of RAS mutation status (both KRAS and NRAS), and it is good practice to include BRAF. In Non-Small Cell Lung Cancer (NSCLC)...

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Main Author:	Ian A. Cree
Format:	Article
Language:	English
Published:	Elsevier 2016-06-01
Series:	Biomolecular Detection and Quantification
Subjects:	PCR Cancer Colorectal NRAS KRAS Lung
Online Access:	http://www.sciencedirect.com/science/article/pii/S2214753516300080

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spelling	doaj-1aff1d4f167d4dfdbf59f90965d57a1c2020-11-24T21:47:21ZengElsevierBiomolecular Detection and Quantification2214-75352016-06-018C293210.1016/j.bdq.2016.05.001Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)Ian A. CreeRAS mutation analysis is an important companion diagnostic test. Treatment of colorectal cancer with anti-Epidermal Growth Factor Receptor (EGFR) therapy requires demonstration of RAS mutation status (both KRAS and NRAS), and it is good practice to include BRAF. In Non-Small Cell Lung Cancer (NSCLC) and melanoma, assessment of RAS mutation status can be helpful in triaging patient samples for more extensive testing. This mini-review will discuss the role of PCR methods in providing rapid diagnostic information for cancer patients.http://www.sciencedirect.com/science/article/pii/S2214753516300080PCRCancerColorectalNRASKRASLung
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ian A. Cree
spellingShingle	Ian A. Cree Diagnostic RAS mutation analysis by polymerase chain reaction (PCR) Biomolecular Detection and Quantification PCR Cancer Colorectal NRAS KRAS Lung
author_facet	Ian A. Cree
author_sort	Ian A. Cree
title	Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)
title_short	Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)
title_full	Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)
title_fullStr	Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)
title_full_unstemmed	Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)
title_sort	diagnostic ras mutation analysis by polymerase chain reaction (pcr)
publisher	Elsevier
series	Biomolecular Detection and Quantification
issn	2214-7535
publishDate	2016-06-01
description	RAS mutation analysis is an important companion diagnostic test. Treatment of colorectal cancer with anti-Epidermal Growth Factor Receptor (EGFR) therapy requires demonstration of RAS mutation status (both KRAS and NRAS), and it is good practice to include BRAF. In Non-Small Cell Lung Cancer (NSCLC) and melanoma, assessment of RAS mutation status can be helpful in triaging patient samples for more extensive testing. This mini-review will discuss the role of PCR methods in providing rapid diagnostic information for cancer patients.
topic	PCR Cancer Colorectal NRAS KRAS Lung
url	http://www.sciencedirect.com/science/article/pii/S2214753516300080
work_keys_str_mv	AT ianacree diagnosticrasmutationanalysisbypolymerasechainreactionpcr
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Diagnostic RAS mutation analysis by polymerase chain reaction (PCR)

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