Diet Supplementation with Fish-Derived Extracts Suppresses Diabetes and Modulates Intestinal Microbiome in a Murine Model of Diet-Induced Obesity
Metabolic syndrome-related diseases affect millions of people worldwide. It is well established that changes in nutritional habits and lifestyle can improve or prevent metabolic-related pathologies such as type-2 diabetes and obesity. Previous reports have shown that nutritional supplements have the...
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doaj-1b005e455c13417295d14cff1257c5712021-05-31T23:43:20ZengMDPI AGMarine Drugs1660-33972021-05-011926826810.3390/md19050268Diet Supplementation with Fish-Derived Extracts Suppresses Diabetes and Modulates Intestinal Microbiome in a Murine Model of Diet-Induced ObesityKonstantinos Axarlis0Maria G. Daskalaki1Sofia Michailidou2Nikolais Androulaki3Antiopi Tsoureki4Evangelia Mouchtaropoulou5Ourania Kolliniati6Ioanna Lapi7Eirini Dermitzaki8Maria Venihaki9Katerina Kousoulaki10Anagnostis Argiriou11Zouhir El Marsni12Christos Tsatsanis13Laboratory of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, GreeceLaboratory of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, GreeceInstitute of Applied Biosciences (INAB), CERTH, Thermi, 57001 Thessaloniki, GreeceLaboratory of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, GreeceInstitute of Applied Biosciences (INAB), CERTH, Thermi, 57001 Thessaloniki, GreeceInstitute of Applied Biosciences (INAB), CERTH, Thermi, 57001 Thessaloniki, GreeceLaboratory of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, GreeceLaboratory of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, GreeceLaboratory of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, GreeceLaboratory of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, GreeceDepartment of Nutrition and Feed Technology, Nofima AS, 5141 Bergen, NorwayInstitute of Applied Biosciences (INAB), CERTH, Thermi, 57001 Thessaloniki, GreeceSeagarden AS, 4262 Avaldsnes, NorwayLaboratory of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, GreeceMetabolic syndrome-related diseases affect millions of people worldwide. It is well established that changes in nutritional habits and lifestyle can improve or prevent metabolic-related pathologies such as type-2 diabetes and obesity. Previous reports have shown that nutritional supplements have the capacity to limit glucose intolerance and suppress diabetes development. In this study, we investigated the effect of dietary supplementation with fish-derived extracts on obesity and type 2 diabetes and their impact on gut microbial composition. We showed that nutritional supplements containing Fish Complex (FC), Fish Complex combined with Cod Powder (FC + CP), or Cod Powder combined with Collagen (CP + C) improved glucose intolerance, independent of abdominal fat accumulation, in a mouse model of diet-induced obesity and type 2 diabetes. In addition, collagen-containing supplements distinctly modulate the gut microbiome in high-fat induced obesity in mice. Our results suggest that fish-derived supplements suppress diet-induced type 2 diabetes, which may be partly mediated through changes in the gut microbiome. Thus, fish-derived supplements and particularly the ones containing fish collagen have potential beneficial properties as dietary supplements in managing type 2 diabetes and metabolic syndrome via modulation of the gut microbiome.https://www.mdpi.com/1660-3397/19/5/268obesitytype 2 diabetesinsulin resistancefish extractcollagengut microbiome |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Konstantinos Axarlis Maria G. Daskalaki Sofia Michailidou Nikolais Androulaki Antiopi Tsoureki Evangelia Mouchtaropoulou Ourania Kolliniati Ioanna Lapi Eirini Dermitzaki Maria Venihaki Katerina Kousoulaki Anagnostis Argiriou Zouhir El Marsni Christos Tsatsanis |
spellingShingle |
Konstantinos Axarlis Maria G. Daskalaki Sofia Michailidou Nikolais Androulaki Antiopi Tsoureki Evangelia Mouchtaropoulou Ourania Kolliniati Ioanna Lapi Eirini Dermitzaki Maria Venihaki Katerina Kousoulaki Anagnostis Argiriou Zouhir El Marsni Christos Tsatsanis Diet Supplementation with Fish-Derived Extracts Suppresses Diabetes and Modulates Intestinal Microbiome in a Murine Model of Diet-Induced Obesity Marine Drugs obesity type 2 diabetes insulin resistance fish extract collagen gut microbiome |
author_facet |
Konstantinos Axarlis Maria G. Daskalaki Sofia Michailidou Nikolais Androulaki Antiopi Tsoureki Evangelia Mouchtaropoulou Ourania Kolliniati Ioanna Lapi Eirini Dermitzaki Maria Venihaki Katerina Kousoulaki Anagnostis Argiriou Zouhir El Marsni Christos Tsatsanis |
author_sort |
Konstantinos Axarlis |
title |
Diet Supplementation with Fish-Derived Extracts Suppresses Diabetes and Modulates Intestinal Microbiome in a Murine Model of Diet-Induced Obesity |
title_short |
Diet Supplementation with Fish-Derived Extracts Suppresses Diabetes and Modulates Intestinal Microbiome in a Murine Model of Diet-Induced Obesity |
title_full |
Diet Supplementation with Fish-Derived Extracts Suppresses Diabetes and Modulates Intestinal Microbiome in a Murine Model of Diet-Induced Obesity |
title_fullStr |
Diet Supplementation with Fish-Derived Extracts Suppresses Diabetes and Modulates Intestinal Microbiome in a Murine Model of Diet-Induced Obesity |
title_full_unstemmed |
Diet Supplementation with Fish-Derived Extracts Suppresses Diabetes and Modulates Intestinal Microbiome in a Murine Model of Diet-Induced Obesity |
title_sort |
diet supplementation with fish-derived extracts suppresses diabetes and modulates intestinal microbiome in a murine model of diet-induced obesity |
publisher |
MDPI AG |
series |
Marine Drugs |
issn |
1660-3397 |
publishDate |
2021-05-01 |
description |
Metabolic syndrome-related diseases affect millions of people worldwide. It is well established that changes in nutritional habits and lifestyle can improve or prevent metabolic-related pathologies such as type-2 diabetes and obesity. Previous reports have shown that nutritional supplements have the capacity to limit glucose intolerance and suppress diabetes development. In this study, we investigated the effect of dietary supplementation with fish-derived extracts on obesity and type 2 diabetes and their impact on gut microbial composition. We showed that nutritional supplements containing Fish Complex (FC), Fish Complex combined with Cod Powder (FC + CP), or Cod Powder combined with Collagen (CP + C) improved glucose intolerance, independent of abdominal fat accumulation, in a mouse model of diet-induced obesity and type 2 diabetes. In addition, collagen-containing supplements distinctly modulate the gut microbiome in high-fat induced obesity in mice. Our results suggest that fish-derived supplements suppress diet-induced type 2 diabetes, which may be partly mediated through changes in the gut microbiome. Thus, fish-derived supplements and particularly the ones containing fish collagen have potential beneficial properties as dietary supplements in managing type 2 diabetes and metabolic syndrome via modulation of the gut microbiome. |
topic |
obesity type 2 diabetes insulin resistance fish extract collagen gut microbiome |
url |
https://www.mdpi.com/1660-3397/19/5/268 |
work_keys_str_mv |
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