Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation

Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation

Metazoan genomes contain many clusters of conserved noncoding elements. Here, the authors provide evidence that these clusters coincide with distinct topologically associating domains in humans and Drosophila, revealing a conserved regulatory genomic architecture.

Bibliographic Details
Main Authors: Nathan Harmston, Elizabeth Ing-Simmons, Ge Tan, Malcolm Perry, Matthias Merkenschlager, Boris Lenhard
Format: Article
Language:English
Published: Nature Publishing Group 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00524-5
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spelling doaj-1b04c3b1a6a64b378ed9795e790183ff2021-05-11T07:46:45ZengNature Publishing GroupNature Communications2041-17232017-09-018111310.1038/s41467-017-00524-5Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservationNathan Harmston0Elizabeth Ing-Simmons1Ge Tan2Malcolm Perry3Matthias Merkenschlager4Boris Lenhard5Computational Regulatory Genomics, MRC London Institute of Medical SciencesComputational Regulatory Genomics, MRC London Institute of Medical SciencesComputational Regulatory Genomics, MRC London Institute of Medical SciencesComputational Regulatory Genomics, MRC London Institute of Medical SciencesInstitute of Clinical Sciences, Faculty of Medicine, Imperial College LondonComputational Regulatory Genomics, MRC London Institute of Medical SciencesMetazoan genomes contain many clusters of conserved noncoding elements. Here, the authors provide evidence that these clusters coincide with distinct topologically associating domains in humans and Drosophila, revealing a conserved regulatory genomic architecture.https://doi.org/10.1038/s41467-017-00524-5
collection DOAJ
language English
format Article
sources DOAJ
author Nathan Harmston
Elizabeth Ing-Simmons
Ge Tan
Malcolm Perry
Matthias Merkenschlager
Boris Lenhard
spellingShingle Nathan Harmston
Elizabeth Ing-Simmons
Ge Tan
Malcolm Perry
Matthias Merkenschlager
Boris Lenhard
Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation
Nature Communications
author_facet Nathan Harmston
Elizabeth Ing-Simmons
Ge Tan
Malcolm Perry
Matthias Merkenschlager
Boris Lenhard
author_sort Nathan Harmston
title Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation
title_short Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation
title_full Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation
title_fullStr Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation
title_full_unstemmed Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation
title_sort topologically associating domains are ancient features that coincide with metazoan clusters of extreme noncoding conservation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-09-01
description Metazoan genomes contain many clusters of conserved noncoding elements. Here, the authors provide evidence that these clusters coincide with distinct topologically associating domains in humans and Drosophila, revealing a conserved regulatory genomic architecture.
url https://doi.org/10.1038/s41467-017-00524-5
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