Exosomes: Potential Therapies for Disease via Regulating TLRs
Exosomes are small membrane vesicles that retain various substances such as proteins, nucleic acids, and small RNAs. Exosomes play crucial roles in many physiological and pathological processes, including innate immunity. Innate immunity is an important process that protects the organism through act...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2020-01-01
|
Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/2020/2319616 |
id |
doaj-1b0c8ebd1d424d8fb0317947dc4a5d73 |
---|---|
record_format |
Article |
spelling |
doaj-1b0c8ebd1d424d8fb0317947dc4a5d732020-11-25T02:49:15ZengHindawi LimitedMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/23196162319616Exosomes: Potential Therapies for Disease via Regulating TLRsHong-Yan Guo0An-Chun Cheng1Ming-Shu Wang2Zhong-Qiong Yin3Ren-Yong Jia4Research Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang District, Chengdu 611130, ChinaResearch Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang District, Chengdu 611130, ChinaResearch Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang District, Chengdu 611130, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, Wenjiang District, Chengdu 611130, ChinaResearch Center of Avian Disease, College of Veterinary Medicine of Sichuan Agricultural University, Wenjiang District, Chengdu 611130, ChinaExosomes are small membrane vesicles that retain various substances such as proteins, nucleic acids, and small RNAs. Exosomes play crucial roles in many physiological and pathological processes, including innate immunity. Innate immunity is an important process that protects the organism through activating pattern recognition receptors (PRRs), which then can induce inflammatory factors to resist pathogen invasion. Toll-like receptor (TLR) is one member of PRRs and is important in pathogen clearance and nervous disease development. Although exosomes and TLRs are two independent materials, abundant evidences imply exosomes can regulate innate immunity through integrating with TLRs. Herein, we review the most recent data regarding exosome regulation of TLR pathways. Specifically, exosome-containing materials can regulate TLR pathways through the interaction with TLRs. This is a new strategy regulating immunity to resist pathogens and therapy diseases, which provide a potential method to cure diseases.http://dx.doi.org/10.1155/2020/2319616 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hong-Yan Guo An-Chun Cheng Ming-Shu Wang Zhong-Qiong Yin Ren-Yong Jia |
spellingShingle |
Hong-Yan Guo An-Chun Cheng Ming-Shu Wang Zhong-Qiong Yin Ren-Yong Jia Exosomes: Potential Therapies for Disease via Regulating TLRs Mediators of Inflammation |
author_facet |
Hong-Yan Guo An-Chun Cheng Ming-Shu Wang Zhong-Qiong Yin Ren-Yong Jia |
author_sort |
Hong-Yan Guo |
title |
Exosomes: Potential Therapies for Disease via Regulating TLRs |
title_short |
Exosomes: Potential Therapies for Disease via Regulating TLRs |
title_full |
Exosomes: Potential Therapies for Disease via Regulating TLRs |
title_fullStr |
Exosomes: Potential Therapies for Disease via Regulating TLRs |
title_full_unstemmed |
Exosomes: Potential Therapies for Disease via Regulating TLRs |
title_sort |
exosomes: potential therapies for disease via regulating tlrs |
publisher |
Hindawi Limited |
series |
Mediators of Inflammation |
issn |
0962-9351 1466-1861 |
publishDate |
2020-01-01 |
description |
Exosomes are small membrane vesicles that retain various substances such as proteins, nucleic acids, and small RNAs. Exosomes play crucial roles in many physiological and pathological processes, including innate immunity. Innate immunity is an important process that protects the organism through activating pattern recognition receptors (PRRs), which then can induce inflammatory factors to resist pathogen invasion. Toll-like receptor (TLR) is one member of PRRs and is important in pathogen clearance and nervous disease development. Although exosomes and TLRs are two independent materials, abundant evidences imply exosomes can regulate innate immunity through integrating with TLRs. Herein, we review the most recent data regarding exosome regulation of TLR pathways. Specifically, exosome-containing materials can regulate TLR pathways through the interaction with TLRs. This is a new strategy regulating immunity to resist pathogens and therapy diseases, which provide a potential method to cure diseases. |
url |
http://dx.doi.org/10.1155/2020/2319616 |
work_keys_str_mv |
AT hongyanguo exosomespotentialtherapiesfordiseaseviaregulatingtlrs AT anchuncheng exosomespotentialtherapiesfordiseaseviaregulatingtlrs AT mingshuwang exosomespotentialtherapiesfordiseaseviaregulatingtlrs AT zhongqiongyin exosomespotentialtherapiesfordiseaseviaregulatingtlrs AT renyongjia exosomespotentialtherapiesfordiseaseviaregulatingtlrs |
_version_ |
1715379450845069312 |