Canine IL4-10 fusion protein provides disease modifying activity in a canine model of OA; an exploratory study.

Canine IL4-10 fusion protein provides disease modifying activity in a canine model of OA; an exploratory study.

<h4>Objective</h4>An ideal disease modifying osteoarthritis drug (DMOAD) has chondroprotective, anti-inflammatory, and analgesic effects. This study describes the production and characterization of a canine IL4-10 fusion protein (IL4-10 FP) and evaluates its in vivo DMOAD activity in a c...

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Bibliographic Details
Main Authors: E M van Helvoort, J Popov-Celeketic, N Eijkelkamp, K Coeleveld, M A Tryfonidou, C D Wijne, C E Hack, F P J G Lafeber, S C Mastbergen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0219587

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