Canine IL4-10 fusion protein provides disease modifying activity in a canine model of OA; an exploratory study.
<h4>Objective</h4>An ideal disease modifying osteoarthritis drug (DMOAD) has chondroprotective, anti-inflammatory, and analgesic effects. This study describes the production and characterization of a canine IL4-10 fusion protein (IL4-10 FP) and evaluates its in vivo DMOAD activity in a c...
Main Authors: | E M van Helvoort, J Popov-Celeketic, N Eijkelkamp, K Coeleveld, M A Tryfonidou, C D Wijne, C E Hack, F P J G Lafeber, S C Mastbergen |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0219587 |
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