Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.

Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.

Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to display rapid-acting antidepressant activity based on pharmacodynamic similarities to the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine. In addition to binding to NMDA receptors, dextromethorphan...

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Bibliographic Details
Main Authors: Linda Nguyen, Matthew J Robson, Jason R Healy, Anna L Scandinaro, Rae R Matsumoto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3938562?pdf=render

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