Xiaoyaosan Ameliorates Chronic Immobilization Stress-Induced Depression-Like Behaviors and Anorexia in Rats: The Role of the Nesfatin-1–Oxytocin–Proopiomelanocortin Neural Pathway in the Hypothalamus

Xiaoyaosan Ameliorates Chronic Immobilization Stress-Induced Depression-Like Behaviors and Anorexia in Rats: The Role of the Nesfatin-1–Oxytocin–Proopiomelanocortin Neural Pathway in the Hypothalamus

Background: Chronic stress is an important risk factor for depression. The nesfatin-1 (NES1)–oxytocin (OT)–proopiomelanocortin (POMC) neural pathway, which is involved in the stress response, was recently shown to have an anorectic effect in the hypothalamus. Our previous study showed that Xiaoyaosa...

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Bibliographic Details
Main Authors: Qingyu Ma, Xiaojuan Li, Zhiyi Yan, Haiyan Jiao, Tingye Wang, Yajing Hou, Youming Jiang, Yueyun Liu, Jiaxu Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Psychiatry
Subjects:
Xiaoyaosan
chronic immobilization stress
depression
anorexia
nesfatin-1
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2019.00910/full

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