Stereotactic Radiotherapy in the Treatment of Paraneoplastic Vasculitis in Oligometastatic Renal Cell Carcinoma

• Main Authors: Laura Burgess, Marissa Keenan, Alan Liang Zhou, Kiefer Lypka, Delvina Hasimja Saraqini, Jeff Yao, Samuel Martin, Christopher Morash, James Watterson, Christina Canil, Robert MacRae
• Format: Article
• Language: English
• Published: MDPI AG 2021-05-01
• Series: Current Oncology
• Subjects: stereotactic radiotherapy (SBRT); renal cell carcinoma (RCC); paraneoplastic vasculitis; paraneoplastic syndrome; oligometastases
• Online Access: https://www.mdpi.com/1718-7729/28/3/162
• ISSN: 1198-0052; 1718-7729

Approximately 20% of renal cell carcinoma (RCC) is diagnosed because of paraneoplastic manifestations. RCC has been associated with a large variety of paraneoplastic syndromes (PNS), but it is rarely associated with PNS vasculitis. We present a case of a previously healthy male who presented with systemic vasculitis; bitemporal headaches, diplopia, polyarthritis, palpable purpura, tongue lesion, peri-orbital edema, scleritis, chondritis and constitutional symptoms. He was subsequently found to have oligometastatic RCC. Both his primary lesion and site of oligometastasis were treated with stereotactic radiotherapy (SBRT) and resulted in the resolution of his vasculitis, as well as sustained oncologic response. This is the first case to demonstrate that effective sustained treatment for PNS vasculitis due to oligometastatic RCC is possible with SBRT.