Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance
Abstract Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia include low sensitivity and specificity, high costs, and a low parti...
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doaj-1b1fb79b0bf243579e8d5ab29c56d9c62020-11-25T01:40:48ZengBMCMolecular Cancer1476-45982020-03-0119112110.1186/s12943-020-01175-9Role of non-coding RNA networks in leukemia progression, metastasis and drug resistanceAjaz A. Bhat0Salma N. Younes1Syed Shadab Raza2Lubna Zarif3Sabah Nisar4Ikhlak Ahmed5Rashid Mir6Sachin Kumar7Surender K. Sharawat8Sheema Hashem9Imadeldin Elfaki10Michal Kulinski11Shilpa Kuttikrishnan12Kirti S. Prabhu13Abdul Q. Khan14Santosh K. Yadav15Wael El-Rifai16Mohammad A. Zargar17Hatem Zayed18Mohammad Haris19Shahab Uddin20Translational Medicine, Sidra MedicineDepartment of Biomedical Science, College of Health Sciences, Qatar UniversityLaboratory for Stem Cell & Restorative Neurology, Era’s Lucknow Medical College and HospitalDepartment of Biomedical Science, College of Health Sciences, Qatar UniversityTranslational Medicine, Sidra MedicineTranslational Medicine, Sidra MedicineDepartment of Medical Lab Technology, Faculty of Applied Medical Sciences, University of TabukDepartment of Medical Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical SciencesDepartment of Medical Oncology, Dr. B. R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical SciencesTranslational Medicine, Sidra MedicineDepartment of Biochemistry, Faculty of Science, University of TabukTranslational Research Institute, Academic Health System, Hamad Medical CorporationTranslational Research Institute, Academic Health System, Hamad Medical CorporationTranslational Research Institute, Academic Health System, Hamad Medical CorporationTranslational Research Institute, Academic Health System, Hamad Medical CorporationTranslational Medicine, Sidra MedicineDepartment of Surgery, University of MiamiDepartment of Biotechnology, Central University of KashmirDepartment of Biomedical Science, College of Health Sciences, Qatar UniversityTranslational Medicine, Sidra MedicineTranslational Research Institute, Academic Health System, Hamad Medical CorporationAbstract Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia include low sensitivity and specificity, high costs, and a low participation rate. An approach based on novel and innovative biomarkers with high accuracy from peripheral blood offers a comfortable and appealing alternative to patients, potentially leading to a higher participation rate. Recently, non-coding RNAs due to their involvement in vital oncogenic processes such as differentiation, proliferation, migration, angiogenesis and apoptosis have attracted much attention as potential diagnostic and prognostic biomarkers in leukemia. Emerging lines of evidence have shown that the mutational spectrum and dysregulated expression of non-coding RNA genes are closely associated with the development and progression of various cancers, including leukemia. In this review, we highlight the expression and functional roles of different types of non-coding RNAs in leukemia and discuss their potential clinical applications as diagnostic or prognostic biomarkers and therapeutic targets.http://link.springer.com/article/10.1186/s12943-020-01175-9CancerCircular RNAsChromatinDrug resistanceEpigeneticsGene regulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ajaz A. Bhat Salma N. Younes Syed Shadab Raza Lubna Zarif Sabah Nisar Ikhlak Ahmed Rashid Mir Sachin Kumar Surender K. Sharawat Sheema Hashem Imadeldin Elfaki Michal Kulinski Shilpa Kuttikrishnan Kirti S. Prabhu Abdul Q. Khan Santosh K. Yadav Wael El-Rifai Mohammad A. Zargar Hatem Zayed Mohammad Haris Shahab Uddin |
spellingShingle |
Ajaz A. Bhat Salma N. Younes Syed Shadab Raza Lubna Zarif Sabah Nisar Ikhlak Ahmed Rashid Mir Sachin Kumar Surender K. Sharawat Sheema Hashem Imadeldin Elfaki Michal Kulinski Shilpa Kuttikrishnan Kirti S. Prabhu Abdul Q. Khan Santosh K. Yadav Wael El-Rifai Mohammad A. Zargar Hatem Zayed Mohammad Haris Shahab Uddin Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance Molecular Cancer Cancer Circular RNAs Chromatin Drug resistance Epigenetics Gene regulation |
author_facet |
Ajaz A. Bhat Salma N. Younes Syed Shadab Raza Lubna Zarif Sabah Nisar Ikhlak Ahmed Rashid Mir Sachin Kumar Surender K. Sharawat Sheema Hashem Imadeldin Elfaki Michal Kulinski Shilpa Kuttikrishnan Kirti S. Prabhu Abdul Q. Khan Santosh K. Yadav Wael El-Rifai Mohammad A. Zargar Hatem Zayed Mohammad Haris Shahab Uddin |
author_sort |
Ajaz A. Bhat |
title |
Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance |
title_short |
Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance |
title_full |
Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance |
title_fullStr |
Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance |
title_full_unstemmed |
Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance |
title_sort |
role of non-coding rna networks in leukemia progression, metastasis and drug resistance |
publisher |
BMC |
series |
Molecular Cancer |
issn |
1476-4598 |
publishDate |
2020-03-01 |
description |
Abstract Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia include low sensitivity and specificity, high costs, and a low participation rate. An approach based on novel and innovative biomarkers with high accuracy from peripheral blood offers a comfortable and appealing alternative to patients, potentially leading to a higher participation rate. Recently, non-coding RNAs due to their involvement in vital oncogenic processes such as differentiation, proliferation, migration, angiogenesis and apoptosis have attracted much attention as potential diagnostic and prognostic biomarkers in leukemia. Emerging lines of evidence have shown that the mutational spectrum and dysregulated expression of non-coding RNA genes are closely associated with the development and progression of various cancers, including leukemia. In this review, we highlight the expression and functional roles of different types of non-coding RNAs in leukemia and discuss their potential clinical applications as diagnostic or prognostic biomarkers and therapeutic targets. |
topic |
Cancer Circular RNAs Chromatin Drug resistance Epigenetics Gene regulation |
url |
http://link.springer.com/article/10.1186/s12943-020-01175-9 |
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