Aphrodisiac Activity of Eulophia macrobulbon Extract on Erectile Dysfunction in Male Aged Rats
This study investigated the effect of Eulophia macrobulbon (EM) extract on sexual performance in aged-related erectile dysfunction (ED) rats. The ethanol EM extract at the doses of 15, 150, and 450 and sildenafil citrate at the dose of 5 mg/kg body weight (BW) were administered orally to the aged ma...
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Online Access: | http://dx.doi.org/10.1155/2018/6217029 |
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doaj-1b2ad67706b545d6b8dde91f69016eea2020-11-24T20:45:57ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/62170296217029Aphrodisiac Activity of Eulophia macrobulbon Extract on Erectile Dysfunction in Male Aged RatsWatcharaporn Preedapirom0Kanokwan Changwichit1Piyarat Srisawang2Kornkanok Ingkaninan3Pornnarin Taepavarapruk4Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, ThailandDepartment of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, ThailandDepartment of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, ThailandDepartment of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, ThailandDepartment of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, ThailandThis study investigated the effect of Eulophia macrobulbon (EM) extract on sexual performance in aged-related erectile dysfunction (ED) rats. The ethanol EM extract at the doses of 15, 150, and 450 and sildenafil citrate at the dose of 5 mg/kg body weight (BW) were administered orally to the aged male rats once daily for 21 days. Mating parameters and intracavernosal pressure (ICP) were measured to evaluate their sexual and erection functions. Numbers of sperm and sperm motility as well as the diameter of seminiferous tubules were observed. The serum testosterone and 3’,5’-cyclic guanosine monophosphate (cGMP) concentration in the rat penile tissue were analyzed. The results showed the significant increased sexual motivation, copulatory performance, and ICP of aged rats treated with sildenafil citrate and all doses of EM extract as compared to control aged rats. Moreover, their serum testosterone levels were slightly increased and significant increase in penile cGMP concentration was observed in these aged rats treated with sildenafil citrate and EM extract. The results suggest that treatment with EM could inhibit activity of PDE5 in penile tissue resulting in the increased cGMP level and bring to the improvement of erectile function and sexual performance.http://dx.doi.org/10.1155/2018/6217029 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Watcharaporn Preedapirom Kanokwan Changwichit Piyarat Srisawang Kornkanok Ingkaninan Pornnarin Taepavarapruk |
spellingShingle |
Watcharaporn Preedapirom Kanokwan Changwichit Piyarat Srisawang Kornkanok Ingkaninan Pornnarin Taepavarapruk Aphrodisiac Activity of Eulophia macrobulbon Extract on Erectile Dysfunction in Male Aged Rats BioMed Research International |
author_facet |
Watcharaporn Preedapirom Kanokwan Changwichit Piyarat Srisawang Kornkanok Ingkaninan Pornnarin Taepavarapruk |
author_sort |
Watcharaporn Preedapirom |
title |
Aphrodisiac Activity of Eulophia macrobulbon Extract on Erectile Dysfunction in Male Aged Rats |
title_short |
Aphrodisiac Activity of Eulophia macrobulbon Extract on Erectile Dysfunction in Male Aged Rats |
title_full |
Aphrodisiac Activity of Eulophia macrobulbon Extract on Erectile Dysfunction in Male Aged Rats |
title_fullStr |
Aphrodisiac Activity of Eulophia macrobulbon Extract on Erectile Dysfunction in Male Aged Rats |
title_full_unstemmed |
Aphrodisiac Activity of Eulophia macrobulbon Extract on Erectile Dysfunction in Male Aged Rats |
title_sort |
aphrodisiac activity of eulophia macrobulbon extract on erectile dysfunction in male aged rats |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2018-01-01 |
description |
This study investigated the effect of Eulophia macrobulbon (EM) extract on sexual performance in aged-related erectile dysfunction (ED) rats. The ethanol EM extract at the doses of 15, 150, and 450 and sildenafil citrate at the dose of 5 mg/kg body weight (BW) were administered orally to the aged male rats once daily for 21 days. Mating parameters and intracavernosal pressure (ICP) were measured to evaluate their sexual and erection functions. Numbers of sperm and sperm motility as well as the diameter of seminiferous tubules were observed. The serum testosterone and 3’,5’-cyclic guanosine monophosphate (cGMP) concentration in the rat penile tissue were analyzed. The results showed the significant increased sexual motivation, copulatory performance, and ICP of aged rats treated with sildenafil citrate and all doses of EM extract as compared to control aged rats. Moreover, their serum testosterone levels were slightly increased and significant increase in penile cGMP concentration was observed in these aged rats treated with sildenafil citrate and EM extract. The results suggest that treatment with EM could inhibit activity of PDE5 in penile tissue resulting in the increased cGMP level and bring to the improvement of erectile function and sexual performance. |
url |
http://dx.doi.org/10.1155/2018/6217029 |
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