Efficient Extraction of Bioactive Flavonoids from Ginkgo biloba Leaves Using Deep Eutectic Solvent/Water Mixture as Green Media
Deep eutectic solvent (DES)/water mixture as alternative extraction solvent was proposed for the efficient extraction of Ginkgo flavonoids from Ginkgo biloba leaves. Fifty DESs were prepared and investigated for the extraction of Ginkgo flavonoids. Compared with the present most efficient extractio...
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Croatian Society of Chemical Engineers
2018-10-01
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doaj-1b2b90a6a80a46baa8b48f1ee30663902020-11-25T02:12:26ZengCroatian Society of Chemical EngineersChemical and Biochemical Engineering Quarterly0352-95681846-51532018-10-0132331532410.15255/CABEQ.2017.1146Efficient Extraction of Bioactive Flavonoids from Ginkgo biloba Leaves Using Deep Eutectic Solvent/Water Mixture as Green MediaM. Yang0J. Cao1F. Cao2C. Lu3E. Su4a)College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, China; b)Co-innovation Center for the Sustainable Forestry in Southern China, College of Forestry, Nanjing Forestry University, Nanjing 210037, ChinaCollege of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, ChinaCo-innovation Center for the Sustainable Forestry in Southern China, College of Forestry, Nanjing Forestry University, Nanjing 210037, ChinaCollege of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, Chinaa)College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, China; c)State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, ChinaDeep eutectic solvent (DES)/water mixture as alternative extraction solvent was proposed for the efficient extraction of Ginkgo flavonoids from Ginkgo biloba leaves. Fifty DESs were prepared and investigated for the extraction of Ginkgo flavonoids. Compared with the present most efficient extraction solvent (70 % ethanol in water), three DESs, choline chloride/1,3-butanediol (ChCl/B), choline chloride/levulinic acid (ChCl/LA1), and 1,2-propanediol/levulinic acid (P/LA1), gave obviously higher extraction yields. The extraction process was further optimized systematically. The optimized extraction conditions were as follows: ChCl/LA1 containing 40 % (w/w) water was used as the solvent to extract Ginkgo flavonoids at a solvent to solid ratio of 10:1 (v/w) with stirring at 50 °C and 150 rpm for 15 min. Under the optimal conditions, 99.87 % of Ginkgo flavonoids could be extracted from the Ginkgo biloba leaves powder at a time. Furthermore, the recovery of Ginkgo flavonoids in the DES extraction solution was efficiently achieved using macroporous resin AB-8, which gave a recovery yield of 93.7 %. The DES-based extraction combined with macroporous resin recovery developed in this work can be an efficient alternative method for the extraction and separation of Ginkgo flavonoids from Ginkgo biloba leaves.http://silverstripe.fkit.hr/cabeq/assets/Uploads/04-3-2018.pdfdeep eutectic solventsGinkgo bilobaGinkgo flavonoidsextractionrecovery |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M. Yang J. Cao F. Cao C. Lu E. Su |
spellingShingle |
M. Yang J. Cao F. Cao C. Lu E. Su Efficient Extraction of Bioactive Flavonoids from Ginkgo biloba Leaves Using Deep Eutectic Solvent/Water Mixture as Green Media Chemical and Biochemical Engineering Quarterly deep eutectic solvents Ginkgo biloba Ginkgo flavonoids extraction recovery |
author_facet |
M. Yang J. Cao F. Cao C. Lu E. Su |
author_sort |
M. Yang |
title |
Efficient Extraction of Bioactive Flavonoids from Ginkgo biloba Leaves Using Deep Eutectic Solvent/Water Mixture as Green Media |
title_short |
Efficient Extraction of Bioactive Flavonoids from Ginkgo biloba Leaves Using Deep Eutectic Solvent/Water Mixture as Green Media |
title_full |
Efficient Extraction of Bioactive Flavonoids from Ginkgo biloba Leaves Using Deep Eutectic Solvent/Water Mixture as Green Media |
title_fullStr |
Efficient Extraction of Bioactive Flavonoids from Ginkgo biloba Leaves Using Deep Eutectic Solvent/Water Mixture as Green Media |
title_full_unstemmed |
Efficient Extraction of Bioactive Flavonoids from Ginkgo biloba Leaves Using Deep Eutectic Solvent/Water Mixture as Green Media |
title_sort |
efficient extraction of bioactive flavonoids from ginkgo biloba leaves using deep eutectic solvent/water mixture as green media |
publisher |
Croatian Society of Chemical Engineers |
series |
Chemical and Biochemical Engineering Quarterly |
issn |
0352-9568 1846-5153 |
publishDate |
2018-10-01 |
description |
Deep eutectic solvent (DES)/water mixture as alternative extraction solvent was proposed for the efficient extraction of Ginkgo flavonoids from Ginkgo biloba leaves. Fifty DESs were prepared and investigated for the extraction of Ginkgo flavonoids.
Compared with the present most efficient extraction solvent (70 % ethanol in water), three DESs, choline chloride/1,3-butanediol (ChCl/B), choline chloride/levulinic acid (ChCl/LA1), and 1,2-propanediol/levulinic acid (P/LA1), gave obviously higher extraction yields. The extraction process was further optimized systematically. The optimized extraction conditions were as follows: ChCl/LA1 containing 40 % (w/w) water was used as the solvent to extract Ginkgo flavonoids at a solvent to solid ratio of
10:1 (v/w) with stirring at 50 °C and 150 rpm for 15 min. Under the optimal conditions, 99.87 % of Ginkgo flavonoids could be extracted from the Ginkgo biloba leaves powder at a time. Furthermore, the recovery of Ginkgo flavonoids in the DES extraction solution was efficiently achieved using macroporous resin AB-8, which gave a recovery yield of 93.7 %. The DES-based extraction combined with macroporous resin recovery developed in this work can be an efficient alternative method for the extraction and separation of Ginkgo flavonoids from Ginkgo biloba leaves. |
topic |
deep eutectic solvents Ginkgo biloba Ginkgo flavonoids extraction recovery |
url |
http://silverstripe.fkit.hr/cabeq/assets/Uploads/04-3-2018.pdf |
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