FGF-21 levels in polyuria-polydipsia syndrome
The pathomechanism of primary polydipsia is poorly understood. Recent animal data reported a connection between fibroblast growth factor 21 (FGF-21) and elevated fluid intake independently of hormonal control by the hormone arginine-vasopressin (AVP) and osmotic stimulation. We therefore compared ci...
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Bioscientifica
2018-12-01
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doaj-1b308253cd9e4f2aa5d1343066950fba2020-11-25T02:56:38ZengBioscientificaEndocrine Connections2049-36142049-36142018-12-0171215011506https://doi.org/10.1530/EC-18-0469FGF-21 levels in polyuria-polydipsia syndromeJulie Refardt0Clara Odilia Sailer1Bettina Winzeler2Matthias Johannes Betz3Irina Chifu4Ingeborg Schnyder5Martin Fassnacht6Wiebke Fenske7Mirjam Christ-Crain8Departments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland; Department of Clinical Research, University of Basel, Basel, SwitzerlandDepartments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland; Department of Clinical Research, University of Basel, Basel, SwitzerlandDepartments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland; Department of Clinical Research, University of Basel, Basel, SwitzerlandDepartments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland; Department of Clinical Research, University of Basel, Basel, SwitzerlandDivision of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, GermanyDepartments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland; Department of Clinical Research, University of Basel, Basel, SwitzerlandDivision of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany; Central Laboratory, University Hospital Würzburg, Würzburg, GermanyDepartment of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany; Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, GermanyDepartments of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland; Department of Clinical Research, University of Basel, Basel, SwitzerlandThe pathomechanism of primary polydipsia is poorly understood. Recent animal data reported a connection between fibroblast growth factor 21 (FGF-21) and elevated fluid intake independently of hormonal control by the hormone arginine-vasopressin (AVP) and osmotic stimulation. We therefore compared circulating FGF-21 levels in patients with primary polydipsia to patients with AVP deficiency (central diabetes insipidus) and healthy volunteers. In this prospective cohort study, we analyzed FGF-21 levels of 20 patients with primary polydipsia, 20 patients with central diabetes insipidus and 20 healthy volunteers before and after stimulation with hypertonic saline infusion targeting a plasma sodium level ≥150 mmol/L. The primary outcome was the difference in FGF-21 levels between the three groups. Baseline characteristics were similar between the groups except for patients with central diabetes insipidus being heavier. There was no difference in baseline FGF-21 levels between patients with primary polydipsia and healthy volunteers (122 pg/mL (52,277) vs 193 pg/mL (48,301), but higher levels in patients with central diabetes insipidus were observed (306 pg/mL (114,484); P = 0.037). However, this was not confirmed in a multivariate linear regression analysis after adjusting for age, sex, BMI and smoking status. Osmotic stimulation did not affect FGF-21 levels in either group (difference to baseline: primary polydipsia −23 pg/mL (−43, 22); central diabetes insipidus 17 pg/mL (−76, 88); healthy volunteers −6 pg/mL (−68, 22); P = 0.45). To conclude, FGF-21 levels are not increased in patients with primary polydipsia as compared to central diabetes insipidus or healthy volunteers. FGF-21 therefore does not seem to be causal of elevated fluid intake in these patients.https://ec.bioscientifica.com/view/journals/ec/7/12/EC-18-0469.xmlFGF21diabetes insipidusprimary polydipsiaosmotic stimulationcopeptin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Julie Refardt Clara Odilia Sailer Bettina Winzeler Matthias Johannes Betz Irina Chifu Ingeborg Schnyder Martin Fassnacht Wiebke Fenske Mirjam Christ-Crain |
spellingShingle |
Julie Refardt Clara Odilia Sailer Bettina Winzeler Matthias Johannes Betz Irina Chifu Ingeborg Schnyder Martin Fassnacht Wiebke Fenske Mirjam Christ-Crain FGF-21 levels in polyuria-polydipsia syndrome Endocrine Connections FGF21 diabetes insipidus primary polydipsia osmotic stimulation copeptin |
author_facet |
Julie Refardt Clara Odilia Sailer Bettina Winzeler Matthias Johannes Betz Irina Chifu Ingeborg Schnyder Martin Fassnacht Wiebke Fenske Mirjam Christ-Crain |
author_sort |
Julie Refardt |
title |
FGF-21 levels in polyuria-polydipsia syndrome |
title_short |
FGF-21 levels in polyuria-polydipsia syndrome |
title_full |
FGF-21 levels in polyuria-polydipsia syndrome |
title_fullStr |
FGF-21 levels in polyuria-polydipsia syndrome |
title_full_unstemmed |
FGF-21 levels in polyuria-polydipsia syndrome |
title_sort |
fgf-21 levels in polyuria-polydipsia syndrome |
publisher |
Bioscientifica |
series |
Endocrine Connections |
issn |
2049-3614 2049-3614 |
publishDate |
2018-12-01 |
description |
The pathomechanism of primary polydipsia is poorly understood. Recent animal data reported a connection between fibroblast growth factor 21 (FGF-21) and elevated fluid intake independently of hormonal control by the hormone arginine-vasopressin (AVP) and osmotic stimulation. We therefore compared circulating FGF-21 levels in patients with primary polydipsia to patients with AVP deficiency (central diabetes insipidus) and healthy volunteers. In this prospective cohort study, we analyzed FGF-21 levels of 20 patients with primary polydipsia, 20 patients with central diabetes insipidus and 20 healthy volunteers before and after stimulation with hypertonic saline infusion targeting a plasma sodium level ≥150 mmol/L. The primary outcome was the difference in FGF-21 levels between the three groups. Baseline characteristics were similar between the groups except for patients with central diabetes insipidus being heavier. There was no difference in baseline FGF-21 levels between patients with primary polydipsia and healthy volunteers (122 pg/mL (52,277) vs 193 pg/mL (48,301), but higher levels in patients with central diabetes insipidus were observed (306 pg/mL (114,484); P = 0.037). However, this was not confirmed in a multivariate linear regression analysis after adjusting for age, sex, BMI and smoking status. Osmotic stimulation did not affect FGF-21 levels in either group (difference to baseline: primary polydipsia −23 pg/mL (−43, 22); central diabetes insipidus 17 pg/mL (−76, 88); healthy volunteers −6 pg/mL (−68, 22); P = 0.45). To conclude, FGF-21 levels are not increased in patients with primary polydipsia as compared to central diabetes insipidus or healthy volunteers. FGF-21 therefore does not seem to be causal of elevated fluid intake in these patients. |
topic |
FGF21 diabetes insipidus primary polydipsia osmotic stimulation copeptin |
url |
https://ec.bioscientifica.com/view/journals/ec/7/12/EC-18-0469.xml |
work_keys_str_mv |
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