Association Between Transient Elastography and Controlled Attenuated Parameter and Liver Ultrasound in Children With Cystic Fibrosis
Methods to identify children with cystic fibrosis (CF) at risk for development of advanced liver disease are lacking. We aim to determine the association between liver stiffness measurement (LSM) by vibration‐controlled transient elastography (VCTE) with research ultrasound (US) patterns and convent...
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Wiley
2021-08-01
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Series: | Hepatology Communications |
Online Access: | https://doi.org/10.1002/hep4.1719 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wen Ye Daniel H. Leung Jean P. Molleston Simon C. Ling Karen F. Murray Jennifer L. Nicholas Suiyuan Huang Boaz W. Karmazyn Roger K. Harned Prakash Masand Adina L. Alazraki Oscar M. Navarro Randolph K. Otto Joseph J Palermo Alexander J Towbin Estella M. Alonso Wikrom W. Karnsakul Sarah Jane Schwarzenberg Glenn F Seidel Marilyn Siegel John C. Magee Michael R. Narkewicz A. Jay Freeman |
spellingShingle |
Wen Ye Daniel H. Leung Jean P. Molleston Simon C. Ling Karen F. Murray Jennifer L. Nicholas Suiyuan Huang Boaz W. Karmazyn Roger K. Harned Prakash Masand Adina L. Alazraki Oscar M. Navarro Randolph K. Otto Joseph J Palermo Alexander J Towbin Estella M. Alonso Wikrom W. Karnsakul Sarah Jane Schwarzenberg Glenn F Seidel Marilyn Siegel John C. Magee Michael R. Narkewicz A. Jay Freeman Association Between Transient Elastography and Controlled Attenuated Parameter and Liver Ultrasound in Children With Cystic Fibrosis Hepatology Communications |
author_facet |
Wen Ye Daniel H. Leung Jean P. Molleston Simon C. Ling Karen F. Murray Jennifer L. Nicholas Suiyuan Huang Boaz W. Karmazyn Roger K. Harned Prakash Masand Adina L. Alazraki Oscar M. Navarro Randolph K. Otto Joseph J Palermo Alexander J Towbin Estella M. Alonso Wikrom W. Karnsakul Sarah Jane Schwarzenberg Glenn F Seidel Marilyn Siegel John C. Magee Michael R. Narkewicz A. Jay Freeman |
author_sort |
Wen Ye |
title |
Association Between Transient Elastography and Controlled Attenuated Parameter and Liver Ultrasound in Children With Cystic Fibrosis |
title_short |
Association Between Transient Elastography and Controlled Attenuated Parameter and Liver Ultrasound in Children With Cystic Fibrosis |
title_full |
Association Between Transient Elastography and Controlled Attenuated Parameter and Liver Ultrasound in Children With Cystic Fibrosis |
title_fullStr |
Association Between Transient Elastography and Controlled Attenuated Parameter and Liver Ultrasound in Children With Cystic Fibrosis |
title_full_unstemmed |
Association Between Transient Elastography and Controlled Attenuated Parameter and Liver Ultrasound in Children With Cystic Fibrosis |
title_sort |
association between transient elastography and controlled attenuated parameter and liver ultrasound in children with cystic fibrosis |
publisher |
Wiley |
series |
Hepatology Communications |
issn |
2471-254X |
publishDate |
2021-08-01 |
description |
Methods to identify children with cystic fibrosis (CF) at risk for development of advanced liver disease are lacking. We aim to determine the association between liver stiffness measurement (LSM) by vibration‐controlled transient elastography (VCTE) with research ultrasound (US) patterns and conventional hepatic markers as a potential means to follow liver disease progression in children with CF. ELASTIC (Longitudinal Assessment of Transient Elastography in CF) is a nested cohort of 141 patients, ages 7‐21, enrolled in the Prediction by US of Risk of Hepatic Cirrhosis in CF (PUSH) Study. We studied the association between LSM with research‐grade US patterns (normal [NL], heterogeneous [HTG], homogeneous [HMG], or nodular [NOD]) and conventional hepatic markers. In a subgroup (n = 79), the association between controlled attenuation parameter (CAP) and US pattern was explored. Among 133 subjects undergoing VCTE, NOD participants (n = 26) had a significantly higher median (interquartile range) LSM of 9.1 kPa (6.3, 15.8) versus NL (n = 72, 5.1 kPa [4.2, 7.0]; P < 0.0001), HMG (n = 17, 5.9 kPa [5.2, 7.8]; P = 0.0013), and HTG (n = 18, 6.1 kPa [4.7, 7.0]; P = 0.0008) participants. HMG participants (n = 14) had a significantly higher mean CAP (SD) (270.5 dB/m [61.1]) compared with NL (n = 40, 218.8 dB/m [46.5]; P = 0.0027), HTG (n = 10, 218.1 dB/m [60.7]; P = 0.044), and NOD (n = 15, 222.7 dB/m [56.4]; P = 0.041) participants. LSM had a negative correlation with platelet count (rs = ‐0.28, P = 0.0071) and positive correlation with aspartate aminotransferase–to‐platelet ratio index (rs = 0.38, P = 0.0002), Fibrosis‐4 index (rs = 0.36, P = 0.0007), gamma‐glutamyltransferase (GGT; rs = 0.35, P = 0.0017), GGT‐to‐platelet ratio (rs = 0.35, P = 0.003), and US spleen size z‐score (rs = 0.27, P = 0.0073). Conclusion: VCTE is associated with US patterns and conventional markers in patients with liver disease with CF. |
url |
https://doi.org/10.1002/hep4.1719 |
work_keys_str_mv |
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doaj-1b391aa18d384ad1a5055e9eafc580d32021-08-17T12:59:15ZengWileyHepatology Communications2471-254X2021-08-01581362137210.1002/hep4.1719Association Between Transient Elastography and Controlled Attenuated Parameter and Liver Ultrasound in Children With Cystic FibrosisWen Ye0Daniel H. Leung1Jean P. Molleston2Simon C. Ling3Karen F. Murray4Jennifer L. Nicholas5Suiyuan Huang6Boaz W. Karmazyn7Roger K. Harned8Prakash Masand9Adina L. Alazraki10Oscar M. Navarro11Randolph K. Otto12Joseph J Palermo13Alexander J Towbin14Estella M. Alonso15Wikrom W. Karnsakul16Sarah Jane Schwarzenberg17Glenn F Seidel18Marilyn Siegel19John C. Magee20Michael R. Narkewicz21A. Jay Freeman22Department of Biostatistics University of Michigan School of Public Health Ann Arbor MI USADivision of Gastroenterology, Hepatology and Nutrition Department of Pediatrics Texas Children’s HospitalBaylor College of Medicine Houston TX USAPediatric Gastroenterology, Hepatology and Nutrition Riley Hospital for Children at IU HealthIndiana University School of Medicine Indianapolis IN USAThe Hospital for Sick Children Department of Pediatrics University of Toronto Toronto ON CanadaDivision of Gastroenterology and Hepatology University of Washington and Seattle Children’s Hospital Seattle WA USAMallinckrodt Institute of Radiology Washington University School of Medicine St. Louis MO USADepartment of Biostatistics University of Michigan School of Public Health Ann Arbor MI USAPediatric Radiology Riley Hospital for Children at IU HealthIndiana University School of Medicine Indianapolis IN USADivision of Pediatric Radiology Children’s Hospital Colorado and University of Colorado School of Medicine Aurora CO USADivision of Radiology Texas Children’s Hospital Houston TX USADepartment of Radiology Emory University School of Medicine and Children’s Healthcare of Atlanta Atlanta GA USADepartment of Medical Imaging University of Toronto Toronto ON CanadaDepartment of Radiology University of Washington and Seattle Children’s Hospital Seattle WA USADivision of Pediatric Gastroenterology, Hepatology and Nutrition Cincinnati Children’s Hospital Medical Center Cincinnati OH USADepartment of Radiology Cincinnati Children’s Hospital Medical Center Cincinnati OH USADivision of Pediatric Gastroenterology, Hepatology and Nutrition Ann & Robert H. Lurie Children’s Hospital Chicago IL USADivision of Pediatric Gastroenterology, Hepatology and Nutrition John Hopkins School of Medicine Baltimore MD USAPediatric Gastroenterology University of Minnesota Masonic Children’s Hospital Minneapolis MN USAPediatric Radiology Lucile Packard Children’s Hospital Palo Alto CA USAMallinckrodt Institute of Radiology Washington University School of Medicine St. Louis MO USADepartment of Surgery University of Michigan Medical School Ann Arbor MI USADigestive Health Institute Children’s Hospital Colorado and Section of Pediatric Gastroenterology, Hepatology and Nutrition Department of Pediatrics University of Colorado School of Medicine Aurora CO USADivision of Pediatric Gastroenterology, Hepatology and Nutrition Emory University School of Medicine/Children's Healthcare of Atlanta Atlanta GA USAMethods to identify children with cystic fibrosis (CF) at risk for development of advanced liver disease are lacking. We aim to determine the association between liver stiffness measurement (LSM) by vibration‐controlled transient elastography (VCTE) with research ultrasound (US) patterns and conventional hepatic markers as a potential means to follow liver disease progression in children with CF. ELASTIC (Longitudinal Assessment of Transient Elastography in CF) is a nested cohort of 141 patients, ages 7‐21, enrolled in the Prediction by US of Risk of Hepatic Cirrhosis in CF (PUSH) Study. We studied the association between LSM with research‐grade US patterns (normal [NL], heterogeneous [HTG], homogeneous [HMG], or nodular [NOD]) and conventional hepatic markers. In a subgroup (n = 79), the association between controlled attenuation parameter (CAP) and US pattern was explored. Among 133 subjects undergoing VCTE, NOD participants (n = 26) had a significantly higher median (interquartile range) LSM of 9.1 kPa (6.3, 15.8) versus NL (n = 72, 5.1 kPa [4.2, 7.0]; P < 0.0001), HMG (n = 17, 5.9 kPa [5.2, 7.8]; P = 0.0013), and HTG (n = 18, 6.1 kPa [4.7, 7.0]; P = 0.0008) participants. HMG participants (n = 14) had a significantly higher mean CAP (SD) (270.5 dB/m [61.1]) compared with NL (n = 40, 218.8 dB/m [46.5]; P = 0.0027), HTG (n = 10, 218.1 dB/m [60.7]; P = 0.044), and NOD (n = 15, 222.7 dB/m [56.4]; P = 0.041) participants. LSM had a negative correlation with platelet count (rs = ‐0.28, P = 0.0071) and positive correlation with aspartate aminotransferase–to‐platelet ratio index (rs = 0.38, P = 0.0002), Fibrosis‐4 index (rs = 0.36, P = 0.0007), gamma‐glutamyltransferase (GGT; rs = 0.35, P = 0.0017), GGT‐to‐platelet ratio (rs = 0.35, P = 0.003), and US spleen size z‐score (rs = 0.27, P = 0.0073). Conclusion: VCTE is associated with US patterns and conventional markers in patients with liver disease with CF.https://doi.org/10.1002/hep4.1719 |