HATRIC-based identification of receptors for orphan ligands

HATRIC-based identification of receptors for orphan ligands

Technologies for identifying receptor-ligand pairs on living cells at physiological conditions remain scarce. Here, the authors develop a mass spectrometry-based ligand receptor capture technology that can identify receptors for a diverse range of ligands at physiological pH with as few as a million...

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Main Authors: Nadine Sobotzki, Michael A. Schafroth, Alina Rudnicka, Anika Koetemann, Florian Marty, Sandra Goetze, Yohei Yamauchi, Erick M. Carreira, Bernd Wollscheid
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03936-z
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spelling doaj-1b3ff8e59603407da4c0f41e48155ad32021-05-11T09:40:10ZengNature Publishing GroupNature Communications2041-17232018-04-01911810.1038/s41467-018-03936-zHATRIC-based identification of receptors for orphan ligandsNadine Sobotzki0Michael A. Schafroth1Alina Rudnicka2Anika Koetemann3Florian Marty4Sandra Goetze5Yohei Yamauchi6Erick M. Carreira7Bernd Wollscheid8Department of Health Sciences and Technology & Institute of Molecular Systems Biology & BioMedical Proteomics Platform (BMPP), ETH ZurichDepartment of Chemistry and Applied Biosciences, Laboratory of Organic Chemistry, ETH ZürichUniversity of Zurich, Institute of Molecular Life SciencesDepartment of Health Sciences and Technology & Institute of Molecular Systems Biology & BioMedical Proteomics Platform (BMPP), ETH ZurichDualsystems Biotech AGDepartment of Health Sciences and Technology & Institute of Molecular Systems Biology & BioMedical Proteomics Platform (BMPP), ETH ZurichSchool of Cellular and Molecular Medicine, University of Bristol, Biomedical Sciences Building, University WalkDepartment of Chemistry and Applied Biosciences, Laboratory of Organic Chemistry, ETH ZürichDepartment of Health Sciences and Technology & Institute of Molecular Systems Biology & BioMedical Proteomics Platform (BMPP), ETH ZurichTechnologies for identifying receptor-ligand pairs on living cells at physiological conditions remain scarce. Here, the authors develop a mass spectrometry-based ligand receptor capture technology that can identify receptors for a diverse range of ligands at physiological pH with as few as a million cells.https://doi.org/10.1038/s41467-018-03936-z
collection DOAJ
language English
format Article
sources DOAJ
author Nadine Sobotzki
Michael A. Schafroth
Alina Rudnicka
Anika Koetemann
Florian Marty
Sandra Goetze
Yohei Yamauchi
Erick M. Carreira
Bernd Wollscheid
spellingShingle Nadine Sobotzki
Michael A. Schafroth
Alina Rudnicka
Anika Koetemann
Florian Marty
Sandra Goetze
Yohei Yamauchi
Erick M. Carreira
Bernd Wollscheid
HATRIC-based identification of receptors for orphan ligands
Nature Communications
author_facet Nadine Sobotzki
Michael A. Schafroth
Alina Rudnicka
Anika Koetemann
Florian Marty
Sandra Goetze
Yohei Yamauchi
Erick M. Carreira
Bernd Wollscheid
author_sort Nadine Sobotzki
title HATRIC-based identification of receptors for orphan ligands
title_short HATRIC-based identification of receptors for orphan ligands
title_full HATRIC-based identification of receptors for orphan ligands
title_fullStr HATRIC-based identification of receptors for orphan ligands
title_full_unstemmed HATRIC-based identification of receptors for orphan ligands
title_sort hatric-based identification of receptors for orphan ligands
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-04-01
description Technologies for identifying receptor-ligand pairs on living cells at physiological conditions remain scarce. Here, the authors develop a mass spectrometry-based ligand receptor capture technology that can identify receptors for a diverse range of ligands at physiological pH with as few as a million cells.
url https://doi.org/10.1038/s41467-018-03936-z
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