Dynamic DNA Methylation During Aging: A “Prophet” of Age-Related Outcomes
The biological markers of aging used to predict physical health status in older people are of great interest. Telomere shortening, which occurs during the process of cell replication, was initially considered a promising biomarker for the prediction of age and age-related outcomes (e.g., diseases, l...
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doaj-1b57ee339e224498bc9de9e41a8ae48b2020-11-24T22:01:25ZengFrontiers Media S.A.Frontiers in Genetics1664-80212019-02-011010.3389/fgene.2019.00107441753Dynamic DNA Methylation During Aging: A “Prophet” of Age-Related OutcomesFu-Hui Xiao0Fu-Hui Xiao1Fu-Hui Xiao2Fu-Hui Xiao3Fu-Hui Xiao4Hao-Tian Wang5Hao-Tian Wang6Hao-Tian Wang7Hao-Tian Wang8Hao-Tian Wang9Hao-Tian Wang10Qing-Peng Kong11Qing-Peng Kong12Qing-Peng Kong13Qing-Peng Kong14Qing-Peng Kong15State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, ChinaCenter for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, ChinaKey Laboratory of Healthy Aging Research of Yunnan Province, Kunming, ChinaKunming Key Laboratory of Healthy Aging Study, Kunming, ChinaKIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, ChinaState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, ChinaCenter for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, ChinaKey Laboratory of Healthy Aging Research of Yunnan Province, Kunming, ChinaKunming Key Laboratory of Healthy Aging Study, Kunming, ChinaKIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, ChinaKunming College of Life Science, University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, ChinaCenter for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, ChinaKey Laboratory of Healthy Aging Research of Yunnan Province, Kunming, ChinaKunming Key Laboratory of Healthy Aging Study, Kunming, ChinaKIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming, ChinaThe biological markers of aging used to predict physical health status in older people are of great interest. Telomere shortening, which occurs during the process of cell replication, was initially considered a promising biomarker for the prediction of age and age-related outcomes (e.g., diseases, longevity). However, the high instability in detection and low correlation with age-related outcomes limit the extension of telomere length to the field of prediction. Currently, a growing number of studies have shown that dynamic DNA methylation throughout human lifetime exhibits strong correlation with age and age-related outcomes. Indeed, many researchers have built age prediction models with high accuracy based on age-dependent methylation changes in certain CpG loci. For now, DNA methylation based on epigenetic clocks, namely epigenetic or DNA methylation age, serves as a new standard to track chronological age and predict biological age. Measures of age acceleration (Δage, DNA methylation age – chronological age) have been developed to assess the health status of a person. In addition, there is evidence that an accelerated epigenetic age exists in patients with certain age-related diseases (e.g., Alzheimer’s disease, cardiovascular disease). In this review, we provide an overview of the dynamic signatures of DNA methylation during aging and emphasize its practical utility in the prediction of various age-related outcomes.https://www.frontiersin.org/article/10.3389/fgene.2019.00107/fullDNA methylationepigenetic clockageage-related outcomeprediction |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fu-Hui Xiao Fu-Hui Xiao Fu-Hui Xiao Fu-Hui Xiao Fu-Hui Xiao Hao-Tian Wang Hao-Tian Wang Hao-Tian Wang Hao-Tian Wang Hao-Tian Wang Hao-Tian Wang Qing-Peng Kong Qing-Peng Kong Qing-Peng Kong Qing-Peng Kong Qing-Peng Kong |
spellingShingle |
Fu-Hui Xiao Fu-Hui Xiao Fu-Hui Xiao Fu-Hui Xiao Fu-Hui Xiao Hao-Tian Wang Hao-Tian Wang Hao-Tian Wang Hao-Tian Wang Hao-Tian Wang Hao-Tian Wang Qing-Peng Kong Qing-Peng Kong Qing-Peng Kong Qing-Peng Kong Qing-Peng Kong Dynamic DNA Methylation During Aging: A “Prophet” of Age-Related Outcomes Frontiers in Genetics DNA methylation epigenetic clock age age-related outcome prediction |
author_facet |
Fu-Hui Xiao Fu-Hui Xiao Fu-Hui Xiao Fu-Hui Xiao Fu-Hui Xiao Hao-Tian Wang Hao-Tian Wang Hao-Tian Wang Hao-Tian Wang Hao-Tian Wang Hao-Tian Wang Qing-Peng Kong Qing-Peng Kong Qing-Peng Kong Qing-Peng Kong Qing-Peng Kong |
author_sort |
Fu-Hui Xiao |
title |
Dynamic DNA Methylation During Aging: A “Prophet” of Age-Related Outcomes |
title_short |
Dynamic DNA Methylation During Aging: A “Prophet” of Age-Related Outcomes |
title_full |
Dynamic DNA Methylation During Aging: A “Prophet” of Age-Related Outcomes |
title_fullStr |
Dynamic DNA Methylation During Aging: A “Prophet” of Age-Related Outcomes |
title_full_unstemmed |
Dynamic DNA Methylation During Aging: A “Prophet” of Age-Related Outcomes |
title_sort |
dynamic dna methylation during aging: a “prophet” of age-related outcomes |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2019-02-01 |
description |
The biological markers of aging used to predict physical health status in older people are of great interest. Telomere shortening, which occurs during the process of cell replication, was initially considered a promising biomarker for the prediction of age and age-related outcomes (e.g., diseases, longevity). However, the high instability in detection and low correlation with age-related outcomes limit the extension of telomere length to the field of prediction. Currently, a growing number of studies have shown that dynamic DNA methylation throughout human lifetime exhibits strong correlation with age and age-related outcomes. Indeed, many researchers have built age prediction models with high accuracy based on age-dependent methylation changes in certain CpG loci. For now, DNA methylation based on epigenetic clocks, namely epigenetic or DNA methylation age, serves as a new standard to track chronological age and predict biological age. Measures of age acceleration (Δage, DNA methylation age – chronological age) have been developed to assess the health status of a person. In addition, there is evidence that an accelerated epigenetic age exists in patients with certain age-related diseases (e.g., Alzheimer’s disease, cardiovascular disease). In this review, we provide an overview of the dynamic signatures of DNA methylation during aging and emphasize its practical utility in the prediction of various age-related outcomes. |
topic |
DNA methylation epigenetic clock age age-related outcome prediction |
url |
https://www.frontiersin.org/article/10.3389/fgene.2019.00107/full |
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