Patient-Specific Planning for Thermal Magnetic Resonance of Glioblastoma Multiforme
Thermal intervention is a potent sensitizer of cells to chemo- and radiotherapy in cancer treatment. Glioblastoma multiforme (GBM) is a potential clinical target, given the cancer’s aggressive nature and resistance to current treatment options. This drives research into optimization algorithms for t...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-04-01
|
Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/13/8/1867 |
id |
doaj-1b64b02b5ea443b8a3f91ea6a1339895 |
---|---|
record_format |
Article |
spelling |
doaj-1b64b02b5ea443b8a3f91ea6a13398952021-04-14T23:00:38ZengMDPI AGCancers2072-66942021-04-01131867186710.3390/cancers13081867Patient-Specific Planning for Thermal Magnetic Resonance of Glioblastoma MultiformeEva Oberacker0Cecilia Diesch1Jacek Nadobny2Andre Kuehne3Peter Wust4Pirus Ghadjar5Thoralf Niendorf6Berlin Ultrahigh Field Facility, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, GermanyBerlin Ultrahigh Field Facility, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, GermanyDepartment Radiation Oncology, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyMRI.TOOLS GmbH, 13125 Berlin, GermanyDepartment Radiation Oncology, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment Radiation Oncology, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyBerlin Ultrahigh Field Facility, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, GermanyThermal intervention is a potent sensitizer of cells to chemo- and radiotherapy in cancer treatment. Glioblastoma multiforme (GBM) is a potential clinical target, given the cancer’s aggressive nature and resistance to current treatment options. This drives research into optimization algorithms for treatment planning as well as radiofrequency (RF) applicator design for treatment delivery. In this work, nine clinically realistic GBM target volumes (TVs) for thermal intervention are compared using three optimization algorithms and up to ten RF applicator designs for thermal magnetic resonance. Hyperthermia treatment planning (HTP) was successfully performed for all cases, including very small, large, and even split target volumes. Minimum requirements formulated for the metrics assessing HTP outcome were met and exceeded for all patient specific cases. Results indicate a 16 channel two row arrangement to be most promising. HTP of TVs with a small extent in the cranial–caudal direction in conjunction with a large radial extent remains challenging despite the advanced optimization algorithms used. In general, deep seated targets are favorable. Overall, our findings indicate that a one-size-fits-all RF applicator might not be the ultimate approach in hyperthermia of brain tumors. It stands to reason that modular and reconfigurable RF applicator configurations might best suit the needs of targeting individual GBM geometry.https://www.mdpi.com/2072-6694/13/8/1867thermal magnetic resonanceradiofrequency hyperthermiapatient-specific therapy planningEMF simulationsRF applicatorglioblastoma multiforme |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eva Oberacker Cecilia Diesch Jacek Nadobny Andre Kuehne Peter Wust Pirus Ghadjar Thoralf Niendorf |
spellingShingle |
Eva Oberacker Cecilia Diesch Jacek Nadobny Andre Kuehne Peter Wust Pirus Ghadjar Thoralf Niendorf Patient-Specific Planning for Thermal Magnetic Resonance of Glioblastoma Multiforme Cancers thermal magnetic resonance radiofrequency hyperthermia patient-specific therapy planning EMF simulations RF applicator glioblastoma multiforme |
author_facet |
Eva Oberacker Cecilia Diesch Jacek Nadobny Andre Kuehne Peter Wust Pirus Ghadjar Thoralf Niendorf |
author_sort |
Eva Oberacker |
title |
Patient-Specific Planning for Thermal Magnetic Resonance of Glioblastoma Multiforme |
title_short |
Patient-Specific Planning for Thermal Magnetic Resonance of Glioblastoma Multiforme |
title_full |
Patient-Specific Planning for Thermal Magnetic Resonance of Glioblastoma Multiforme |
title_fullStr |
Patient-Specific Planning for Thermal Magnetic Resonance of Glioblastoma Multiforme |
title_full_unstemmed |
Patient-Specific Planning for Thermal Magnetic Resonance of Glioblastoma Multiforme |
title_sort |
patient-specific planning for thermal magnetic resonance of glioblastoma multiforme |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2021-04-01 |
description |
Thermal intervention is a potent sensitizer of cells to chemo- and radiotherapy in cancer treatment. Glioblastoma multiforme (GBM) is a potential clinical target, given the cancer’s aggressive nature and resistance to current treatment options. This drives research into optimization algorithms for treatment planning as well as radiofrequency (RF) applicator design for treatment delivery. In this work, nine clinically realistic GBM target volumes (TVs) for thermal intervention are compared using three optimization algorithms and up to ten RF applicator designs for thermal magnetic resonance. Hyperthermia treatment planning (HTP) was successfully performed for all cases, including very small, large, and even split target volumes. Minimum requirements formulated for the metrics assessing HTP outcome were met and exceeded for all patient specific cases. Results indicate a 16 channel two row arrangement to be most promising. HTP of TVs with a small extent in the cranial–caudal direction in conjunction with a large radial extent remains challenging despite the advanced optimization algorithms used. In general, deep seated targets are favorable. Overall, our findings indicate that a one-size-fits-all RF applicator might not be the ultimate approach in hyperthermia of brain tumors. It stands to reason that modular and reconfigurable RF applicator configurations might best suit the needs of targeting individual GBM geometry. |
topic |
thermal magnetic resonance radiofrequency hyperthermia patient-specific therapy planning EMF simulations RF applicator glioblastoma multiforme |
url |
https://www.mdpi.com/2072-6694/13/8/1867 |
work_keys_str_mv |
AT evaoberacker patientspecificplanningforthermalmagneticresonanceofglioblastomamultiforme AT ceciliadiesch patientspecificplanningforthermalmagneticresonanceofglioblastomamultiforme AT jaceknadobny patientspecificplanningforthermalmagneticresonanceofglioblastomamultiforme AT andrekuehne patientspecificplanningforthermalmagneticresonanceofglioblastomamultiforme AT peterwust patientspecificplanningforthermalmagneticresonanceofglioblastomamultiforme AT pirusghadjar patientspecificplanningforthermalmagneticresonanceofglioblastomamultiforme AT thoralfniendorf patientspecificplanningforthermalmagneticresonanceofglioblastomamultiforme |
_version_ |
1721526880349192192 |