iRBP-Motif-PSSM: Identification of RNA-Binding Proteins Based on Collaborative Learning
RNAs and RNA-binding proteins (RBPs) in cells can bind with each other to form a nuclear ribonucleoprotein (RNP) complex, playing important roles in life processes, and gene regulation. How to accurately predict the RNA-binding proteins is a big challenge and hot research task. Here, we proposed a n...
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doaj-1b65006c555a49ab8e92f39a4a35ccfb2021-03-30T00:56:05ZengIEEEIEEE Access2169-35362019-01-01716895616896210.1109/ACCESS.2019.29526218895778iRBP-Motif-PSSM: Identification of RNA-Binding Proteins Based on Collaborative LearningXin Gao0Donghua Wang1Jun Zhang2Qing Liao3Bin Liu4https://orcid.org/0000-0002-8520-8374School of Computer Science and Technology, Harbin Institute of Technology, Shenzhen, ChinaDepartment of General Surgery, Heilongjiang Province Land Reclamation Headquarters General Hospital, Harbin, ChinaSchool of Computer Science and Technology, Harbin Institute of Technology, Shenzhen, ChinaSchool of Computer Science and Technology, Harbin Institute of Technology, Shenzhen, ChinaSchool of Computer Science and Technology, Beijing Institute of Technology, Beijing, ChinaRNAs and RNA-binding proteins (RBPs) in cells can bind with each other to form a nuclear ribonucleoprotein (RNP) complex, playing important roles in life processes, and gene regulation. How to accurately predict the RNA-binding proteins is a big challenge and hot research task. Here, we proposed a new computational predictor called iRBP-Motif-PSSM for identifying RNA-binding proteins by combining the motif information and the evolutionary information extracted from the Position Specific Scoring Matrixes. Collaborative Learning was employed to address the instability problem of the predictor. The experimental results showed that iRBP-Motif-PSSM showed better performance than other existing methods for identifying NA-binding proteins, indicating that iRBP-Motif-PSSM is a useful tool for biological analysis.https://ieeexplore.ieee.org/document/8895778/RNA-binding proteinsMotif-PSSMcollaborative learning |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xin Gao Donghua Wang Jun Zhang Qing Liao Bin Liu |
spellingShingle |
Xin Gao Donghua Wang Jun Zhang Qing Liao Bin Liu iRBP-Motif-PSSM: Identification of RNA-Binding Proteins Based on Collaborative Learning IEEE Access RNA-binding proteins Motif-PSSM collaborative learning |
author_facet |
Xin Gao Donghua Wang Jun Zhang Qing Liao Bin Liu |
author_sort |
Xin Gao |
title |
iRBP-Motif-PSSM: Identification of RNA-Binding Proteins Based on Collaborative Learning |
title_short |
iRBP-Motif-PSSM: Identification of RNA-Binding Proteins Based on Collaborative Learning |
title_full |
iRBP-Motif-PSSM: Identification of RNA-Binding Proteins Based on Collaborative Learning |
title_fullStr |
iRBP-Motif-PSSM: Identification of RNA-Binding Proteins Based on Collaborative Learning |
title_full_unstemmed |
iRBP-Motif-PSSM: Identification of RNA-Binding Proteins Based on Collaborative Learning |
title_sort |
irbp-motif-pssm: identification of rna-binding proteins based on collaborative learning |
publisher |
IEEE |
series |
IEEE Access |
issn |
2169-3536 |
publishDate |
2019-01-01 |
description |
RNAs and RNA-binding proteins (RBPs) in cells can bind with each other to form a nuclear ribonucleoprotein (RNP) complex, playing important roles in life processes, and gene regulation. How to accurately predict the RNA-binding proteins is a big challenge and hot research task. Here, we proposed a new computational predictor called iRBP-Motif-PSSM for identifying RNA-binding proteins by combining the motif information and the evolutionary information extracted from the Position Specific Scoring Matrixes. Collaborative Learning was employed to address the instability problem of the predictor. The experimental results showed that iRBP-Motif-PSSM showed better performance than other existing methods for identifying NA-binding proteins, indicating that iRBP-Motif-PSSM is a useful tool for biological analysis. |
topic |
RNA-binding proteins Motif-PSSM collaborative learning |
url |
https://ieeexplore.ieee.org/document/8895778/ |
work_keys_str_mv |
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