THE JOURNAL OF TROPICAL LIFE SCIENCE OPEN ACCESS Freely available online VOL. 5, NO. 2, pp. 88-91, May, 2015 Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L.
Hedyotis corymbosa L., with local name rumput mutiara, is an anti-inflammatory, anti-cancer and hepatoprotective traditional medicine. The ethanol extract of H. corymbosa L. shows inhibitory activity to humanYMB-1 breast cancer cell line with an IC50 of 6.51 μg/mL. The methylene chloride fraction sh...
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doaj-1b684f1b90b448508389ccdfc4ae2e132020-11-24T20:54:00ZengUniversity of BrawijayaJournal of Tropical Life Science2087-55172015-05-01528891THE JOURNAL OF TROPICAL LIFE SCIENCE OPEN ACCESS Freely available online VOL. 5, NO. 2, pp. 88-91, May, 2015 Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L.Nina Artanti0Muhammad Hanafi1Rina Andriyani2Vienna Saraswati3Zalinar Udin4Puspa D. Lotulung5Ken Ichi Fujita6Yoshinosuke Usuki7Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK, Serpong Tangerang-Indonesia 13514/ Jl. Cisitu-Sangkuriang, Gedung 50, Bandung, Indonesia 40135Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK, Serpong Tangerang-Indonesia 13514/ Jl. Cisitu-Sangkuriang, Gedung 50, Bandung, Indonesia 40135Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK, Serpong Tangerang-Indonesia 13514/ Jl. Cisitu-Sangkuriang, Gedung 50, Bandung, Indonesia 40135Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK, Serpong Tangerang-Indonesia 13514/ Jl. Cisitu-Sangkuriang, Gedung 50, Bandung, Indonesia 40135Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK, Serpong Tangerang-Indonesia 13514/ Jl. Cisitu-Sangkuriang, Gedung 50, Bandung, Indonesia 40135Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK, Serpong Tangerang-Indonesia 13514/ Jl. Cisitu-Sangkuriang, Gedung 50, Bandung, Indonesia 40135Material Sciences, Faculty of Science, Osaka City University, JapanMaterial Sciences, Faculty of Science, Osaka City University, JapanHedyotis corymbosa L., with local name rumput mutiara, is an anti-inflammatory, anti-cancer and hepatoprotective traditional medicine. The ethanol extract of H. corymbosa L. shows inhibitory activity to humanYMB-1 breast cancer cell line with an IC50 of 6.51 μg/mL. The methylene chloride fraction shows a potential cytotoxic activity with an IC50 of 2.75 μg/mL. To obtain a lead compound, the extract was further purified by column chromatography. A pure compound is obtained which shows inhibitory activities against YMB-1, HL60 and KB human cell lines with IC50 values of 0.7; 11.0 and 104.2 μg/mL, respectively. Based on the 1D and 2D FT-NMR data, the isolated compound is an asperuloside. http://www.jtrolis.ub.ac.id/index.php/jtrolis/article/view/283/pdf_11asperulosideHedyotis corymbosaHL60KBleafRubiaceaeYMB-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nina Artanti Muhammad Hanafi Rina Andriyani Vienna Saraswati Zalinar Udin Puspa D. Lotulung Ken Ichi Fujita Yoshinosuke Usuki |
spellingShingle |
Nina Artanti Muhammad Hanafi Rina Andriyani Vienna Saraswati Zalinar Udin Puspa D. Lotulung Ken Ichi Fujita Yoshinosuke Usuki THE JOURNAL OF TROPICAL LIFE SCIENCE OPEN ACCESS Freely available online VOL. 5, NO. 2, pp. 88-91, May, 2015 Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L. Journal of Tropical Life Science asperuloside Hedyotis corymbosa HL60 KB leaf Rubiaceae YMB-1 |
author_facet |
Nina Artanti Muhammad Hanafi Rina Andriyani Vienna Saraswati Zalinar Udin Puspa D. Lotulung Ken Ichi Fujita Yoshinosuke Usuki |
author_sort |
Nina Artanti |
title |
THE JOURNAL OF TROPICAL LIFE SCIENCE OPEN ACCESS Freely available online VOL. 5, NO. 2, pp. 88-91, May, 2015 Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L. |
title_short |
THE JOURNAL OF TROPICAL LIFE SCIENCE OPEN ACCESS Freely available online VOL. 5, NO. 2, pp. 88-91, May, 2015 Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L. |
title_full |
THE JOURNAL OF TROPICAL LIFE SCIENCE OPEN ACCESS Freely available online VOL. 5, NO. 2, pp. 88-91, May, 2015 Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L. |
title_fullStr |
THE JOURNAL OF TROPICAL LIFE SCIENCE OPEN ACCESS Freely available online VOL. 5, NO. 2, pp. 88-91, May, 2015 Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L. |
title_full_unstemmed |
THE JOURNAL OF TROPICAL LIFE SCIENCE OPEN ACCESS Freely available online VOL. 5, NO. 2, pp. 88-91, May, 2015 Isolation of an Anti-Cancer Asperuloside from Hedyotis corymbosa L. |
title_sort |
journal of tropical life science open access freely available online vol. 5, no. 2, pp. 88-91, may, 2015 isolation of an anti-cancer asperuloside from hedyotis corymbosa l. |
publisher |
University of Brawijaya |
series |
Journal of Tropical Life Science |
issn |
2087-5517 |
publishDate |
2015-05-01 |
description |
Hedyotis corymbosa L., with local name rumput mutiara, is an anti-inflammatory, anti-cancer and hepatoprotective traditional medicine. The ethanol extract of H. corymbosa L. shows inhibitory activity to humanYMB-1 breast cancer cell line with an IC50 of 6.51 μg/mL. The methylene chloride fraction shows a potential cytotoxic activity with an IC50 of 2.75 μg/mL. To obtain a lead compound, the extract was further purified by column chromatography. A pure compound is obtained which shows inhibitory activities against YMB-1, HL60 and KB human cell lines with IC50 values of 0.7; 11.0 and 104.2 μg/mL, respectively. Based on the 1D and 2D FT-NMR data, the isolated compound is an asperuloside. |
topic |
asperuloside Hedyotis corymbosa HL60 KB leaf Rubiaceae YMB-1 |
url |
http://www.jtrolis.ub.ac.id/index.php/jtrolis/article/view/283/pdf_11 |
work_keys_str_mv |
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