Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma
Glaucoma is a leading cause of blindness worldwide. In glaucoma, a progressive dysfunction and death of retinal ganglion cells occurs, eliminating transfer of visual information to the brain. Currently, the only available therapies target the lowering of intraocular pressure, but many patients conti...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-02-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/10/2/295 |
id |
doaj-1b68f454598f428cbf402e0c99468f00 |
---|---|
record_format |
Article |
spelling |
doaj-1b68f454598f428cbf402e0c99468f002021-02-02T00:04:14ZengMDPI AGCells2073-44092021-02-011029529510.3390/cells10020295Targeting Diet and Exercise for Neuroprotection and Neurorecovery in GlaucomaJames R. Tribble0Flora Hui1Melissa Jöe2Katharina Bell3Vicki Chrysostomou4Jonathan G. Crowston5Pete A. Williams6Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, 171 64 Stockholm, SwedenCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC 3002, AustraliaDepartment of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, 171 64 Stockholm, SwedenSingapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, SingaporeCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC 3002, AustraliaDepartment of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, 171 64 Stockholm, SwedenGlaucoma is a leading cause of blindness worldwide. In glaucoma, a progressive dysfunction and death of retinal ganglion cells occurs, eliminating transfer of visual information to the brain. Currently, the only available therapies target the lowering of intraocular pressure, but many patients continue to lose vision. Emerging pre-clinical and clinical evidence suggests that metabolic deficiencies and defects may play an important role in glaucoma pathophysiology. While pre-clinical studies in animal models have begun to mechanistically uncover these metabolic changes, some existing clinical evidence already points to potential benefits in maintaining metabolic fitness. Modifying diet and exercise can be implemented by patients as an adjunct to intraocular pressure lowering, which may be of therapeutic benefit to retinal ganglion cells in glaucoma.https://www.mdpi.com/2073-4409/10/2/295glaucomaoptic nerveretinal ganglion cellsdietexerciseNAD |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
James R. Tribble Flora Hui Melissa Jöe Katharina Bell Vicki Chrysostomou Jonathan G. Crowston Pete A. Williams |
spellingShingle |
James R. Tribble Flora Hui Melissa Jöe Katharina Bell Vicki Chrysostomou Jonathan G. Crowston Pete A. Williams Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma Cells glaucoma optic nerve retinal ganglion cells diet exercise NAD |
author_facet |
James R. Tribble Flora Hui Melissa Jöe Katharina Bell Vicki Chrysostomou Jonathan G. Crowston Pete A. Williams |
author_sort |
James R. Tribble |
title |
Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma |
title_short |
Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma |
title_full |
Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma |
title_fullStr |
Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma |
title_full_unstemmed |
Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma |
title_sort |
targeting diet and exercise for neuroprotection and neurorecovery in glaucoma |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2021-02-01 |
description |
Glaucoma is a leading cause of blindness worldwide. In glaucoma, a progressive dysfunction and death of retinal ganglion cells occurs, eliminating transfer of visual information to the brain. Currently, the only available therapies target the lowering of intraocular pressure, but many patients continue to lose vision. Emerging pre-clinical and clinical evidence suggests that metabolic deficiencies and defects may play an important role in glaucoma pathophysiology. While pre-clinical studies in animal models have begun to mechanistically uncover these metabolic changes, some existing clinical evidence already points to potential benefits in maintaining metabolic fitness. Modifying diet and exercise can be implemented by patients as an adjunct to intraocular pressure lowering, which may be of therapeutic benefit to retinal ganglion cells in glaucoma. |
topic |
glaucoma optic nerve retinal ganglion cells diet exercise NAD |
url |
https://www.mdpi.com/2073-4409/10/2/295 |
work_keys_str_mv |
AT jamesrtribble targetingdietandexerciseforneuroprotectionandneurorecoveryinglaucoma AT florahui targetingdietandexerciseforneuroprotectionandneurorecoveryinglaucoma AT melissajoe targetingdietandexerciseforneuroprotectionandneurorecoveryinglaucoma AT katharinabell targetingdietandexerciseforneuroprotectionandneurorecoveryinglaucoma AT vickichrysostomou targetingdietandexerciseforneuroprotectionandneurorecoveryinglaucoma AT jonathangcrowston targetingdietandexerciseforneuroprotectionandneurorecoveryinglaucoma AT peteawilliams targetingdietandexerciseforneuroprotectionandneurorecoveryinglaucoma |
_version_ |
1724314675389136896 |