Metabolite Profiling: A Tool for the Biochemical Characterisation of <i>Mycobacterium</i> sp.

Metabolite Profiling: A Tool for the Biochemical Characterisation of <i>Mycobacterium</i> sp.

Over the last decades, the prevalence of drug-resistance in <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), the causative agent of tuberculosis, has increased. These findings have rekindled interest in elucidating the unique adaptive molecular and biochemistry physiology of &...

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Main Authors: Margit Drapal, Paul D. Fraser
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Microorganisms
Subjects:
mycobacteria
metabolomics
anti-TB drugs
Online Access:https://www.mdpi.com/2076-2607/7/5/148
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spelling doaj-1b73c0eaec124efeac7ebd803798602a2020-11-24T22:26:29ZengMDPI AGMicroorganisms2076-26072019-05-017514810.3390/microorganisms7050148microorganisms7050148Metabolite Profiling: A Tool for the Biochemical Characterisation of <i>Mycobacterium</i> sp.Margit Drapal0Paul D. Fraser1School of Biological Sciences, Royal Holloway University of London, Egham Hill, Egham TW20 0EX, UKSchool of Biological Sciences, Royal Holloway University of London, Egham Hill, Egham TW20 0EX, UKOver the last decades, the prevalence of drug-resistance in <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), the causative agent of tuberculosis, has increased. These findings have rekindled interest in elucidating the unique adaptive molecular and biochemistry physiology of <i>Mycobacterium</i>. The use of metabolite profiling independently or in combination with other levels of &#8220;-omic&#8221; analyses has proven an effective approach to elucidate key physiological/biochemical mechanisms associated with <i>Mtb</i> throughout infection. The following review discusses the use of metabolite profiling in the study of tuberculosis, future approaches, and the technical and logistical limitations of the methodology.https://www.mdpi.com/2076-2607/7/5/148mycobacteriametabolomicsanti-TB drugs
collection DOAJ
language English
format Article
sources DOAJ
author Margit Drapal
Paul D. Fraser
spellingShingle Margit Drapal
Paul D. Fraser
Metabolite Profiling: A Tool for the Biochemical Characterisation of <i>Mycobacterium</i> sp.
Microorganisms
mycobacteria
metabolomics
anti-TB drugs
author_facet Margit Drapal
Paul D. Fraser
author_sort Margit Drapal
title Metabolite Profiling: A Tool for the Biochemical Characterisation of <i>Mycobacterium</i> sp.
title_short Metabolite Profiling: A Tool for the Biochemical Characterisation of <i>Mycobacterium</i> sp.
title_full Metabolite Profiling: A Tool for the Biochemical Characterisation of <i>Mycobacterium</i> sp.
title_fullStr Metabolite Profiling: A Tool for the Biochemical Characterisation of <i>Mycobacterium</i> sp.
title_full_unstemmed Metabolite Profiling: A Tool for the Biochemical Characterisation of <i>Mycobacterium</i> sp.
title_sort metabolite profiling: a tool for the biochemical characterisation of <i>mycobacterium</i> sp.
publisher MDPI AG
series Microorganisms
issn 2076-2607
publishDate 2019-05-01
description Over the last decades, the prevalence of drug-resistance in <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), the causative agent of tuberculosis, has increased. These findings have rekindled interest in elucidating the unique adaptive molecular and biochemistry physiology of <i>Mycobacterium</i>. The use of metabolite profiling independently or in combination with other levels of &#8220;-omic&#8221; analyses has proven an effective approach to elucidate key physiological/biochemical mechanisms associated with <i>Mtb</i> throughout infection. The following review discusses the use of metabolite profiling in the study of tuberculosis, future approaches, and the technical and logistical limitations of the methodology.
topic mycobacteria
metabolomics
anti-TB drugs
url https://www.mdpi.com/2076-2607/7/5/148
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AT pauldfraser metaboliteprofilingatoolforthebiochemicalcharacterisationofimycobacteriumisp
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