Cell non-autonomous regulation of health and longevity
As the demographics of the modern world skew older, understanding and mitigating the effects of aging is increasingly important within biomedical research. Recent studies in model organisms demonstrate that the aging process is frequently modified by an organism’s ability to perceive and respond to...
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2020-12-01
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doaj-1b7cfe07a16a4641a4e8dc289916c9602021-05-05T21:50:52ZengeLife Sciences Publications LtdeLife2050-084X2020-12-01910.7554/eLife.62659Cell non-autonomous regulation of health and longevityHillary A Miller0https://orcid.org/0000-0002-8204-7990Elizabeth S Dean1Scott D Pletcher2https://orcid.org/0000-0002-4812-3785Scott F Leiser3https://orcid.org/0000-0002-8003-2955Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, United StatesMolecular & Integrative Physiology Department, University of Michigan, Ann Arbor, United StatesMolecular & Integrative Physiology Department, University of Michigan, Ann Arbor, United StatesMolecular & Integrative Physiology Department, University of Michigan, Ann Arbor, United States; Department of Internal Medicine, University of Michigan, Ann Arbor, United StatesAs the demographics of the modern world skew older, understanding and mitigating the effects of aging is increasingly important within biomedical research. Recent studies in model organisms demonstrate that the aging process is frequently modified by an organism’s ability to perceive and respond to changes in its environment. Many well-studied pathways that influence aging involve sensory cells, frequently neurons, that signal to peripheral tissues and promote survival during the presence of stress. Importantly, this activation of stress response pathways is often sufficient to improve health and longevity even in the absence of stress. Here, we review the current landscape of research highlighting the importance of cell non-autonomous signaling in modulating aging from C. elegans to mammals. We also discuss emerging concepts including retrograde signaling, approaches to mapping these networks, and development of potential therapeutics.https://elifesciences.org/articles/62659aginghealthspanD. melanogasterC. elegansinsulin signalingsensory perception |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hillary A Miller Elizabeth S Dean Scott D Pletcher Scott F Leiser |
spellingShingle |
Hillary A Miller Elizabeth S Dean Scott D Pletcher Scott F Leiser Cell non-autonomous regulation of health and longevity eLife aging healthspan D. melanogaster C. elegans insulin signaling sensory perception |
author_facet |
Hillary A Miller Elizabeth S Dean Scott D Pletcher Scott F Leiser |
author_sort |
Hillary A Miller |
title |
Cell non-autonomous regulation of health and longevity |
title_short |
Cell non-autonomous regulation of health and longevity |
title_full |
Cell non-autonomous regulation of health and longevity |
title_fullStr |
Cell non-autonomous regulation of health and longevity |
title_full_unstemmed |
Cell non-autonomous regulation of health and longevity |
title_sort |
cell non-autonomous regulation of health and longevity |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2020-12-01 |
description |
As the demographics of the modern world skew older, understanding and mitigating the effects of aging is increasingly important within biomedical research. Recent studies in model organisms demonstrate that the aging process is frequently modified by an organism’s ability to perceive and respond to changes in its environment. Many well-studied pathways that influence aging involve sensory cells, frequently neurons, that signal to peripheral tissues and promote survival during the presence of stress. Importantly, this activation of stress response pathways is often sufficient to improve health and longevity even in the absence of stress. Here, we review the current landscape of research highlighting the importance of cell non-autonomous signaling in modulating aging from C. elegans to mammals. We also discuss emerging concepts including retrograde signaling, approaches to mapping these networks, and development of potential therapeutics. |
topic |
aging healthspan D. melanogaster C. elegans insulin signaling sensory perception |
url |
https://elifesciences.org/articles/62659 |
work_keys_str_mv |
AT hillaryamiller cellnonautonomousregulationofhealthandlongevity AT elizabethsdean cellnonautonomousregulationofhealthandlongevity AT scottdpletcher cellnonautonomousregulationofhealthandlongevity AT scottfleiser cellnonautonomousregulationofhealthandlongevity |
_version_ |
1721457839741861888 |