The Anti-Inflammatory Activity of Humic Acid from Borneo Peat Soil in Mice
Humic acid is a humus compound found in peat soil. Humic acid can potentially be used as an anti-inflammatory compound. This study aimed to determine the effect of humic acid on the volume of foot mice edema and to find the best dose that can suppress the degree of edema volume. The animal object wa...
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Universitas Gadjah Mada
2020-04-01
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doaj-1b8c22a923e940eb8f8dc88fd989da2a2020-12-03T06:17:04ZengUniversitas Gadjah MadaMajalah Obat Tradisional1410-59182406-90862020-04-01251222810.22146/mot.4800326593The Anti-Inflammatory Activity of Humic Acid from Borneo Peat Soil in MiceRusliandi Rusliandi0Diah Wulandari Rousdy1Mukarlina Mukarlina2Departement of Biology, Faculty of Mathematics and Natural Sciences, Tanjungpura University, Pontianak, Kalimantan BaratDepartement of Biology, Faculty of Mathematics and Natural Sciences, Tanjungpura University, Pontianak, Kalimantan BaratDepartement of Biology, Faculty of Mathematics and Natural Sciences, Tanjungpura University, Pontianak, Kalimantan BaratHumic acid is a humus compound found in peat soil. Humic acid can potentially be used as an anti-inflammatory compound. This study aimed to determine the effect of humic acid on the volume of foot mice edema and to find the best dose that can suppress the degree of edema volume. The animal object was Swiss mice weighing 25-30 grams and 3 months old. The study used Randomized Block Design (RBD) with positive control, negative control and humic acid treatment with dose 62.5 mg kg-1BW, 125 mg kg-1BW, and 250 mg kg-1BW. The result of this research showed that edema inhibition by the administration of humic acid dose 62,5; 125; 250 mg kg-1 had inflammatory inhibition percentage 2.67%, 13.34%, and 20.01% respectively in 5-hour observation. The best dose of humic acid to suppress inflammation in the mice's paw is a humic acid dose of 250 mg kg-1 compared with value 23.3% of sodium diclofenac as the positive control.https://jurnal.ugm.ac.id/TradMedJ/article/view/48003humic acidpeatedemacarrageenan |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rusliandi Rusliandi Diah Wulandari Rousdy Mukarlina Mukarlina |
spellingShingle |
Rusliandi Rusliandi Diah Wulandari Rousdy Mukarlina Mukarlina The Anti-Inflammatory Activity of Humic Acid from Borneo Peat Soil in Mice Majalah Obat Tradisional humic acid peat edema carrageenan |
author_facet |
Rusliandi Rusliandi Diah Wulandari Rousdy Mukarlina Mukarlina |
author_sort |
Rusliandi Rusliandi |
title |
The Anti-Inflammatory Activity of Humic Acid from Borneo Peat Soil in Mice |
title_short |
The Anti-Inflammatory Activity of Humic Acid from Borneo Peat Soil in Mice |
title_full |
The Anti-Inflammatory Activity of Humic Acid from Borneo Peat Soil in Mice |
title_fullStr |
The Anti-Inflammatory Activity of Humic Acid from Borneo Peat Soil in Mice |
title_full_unstemmed |
The Anti-Inflammatory Activity of Humic Acid from Borneo Peat Soil in Mice |
title_sort |
anti-inflammatory activity of humic acid from borneo peat soil in mice |
publisher |
Universitas Gadjah Mada |
series |
Majalah Obat Tradisional |
issn |
1410-5918 2406-9086 |
publishDate |
2020-04-01 |
description |
Humic acid is a humus compound found in peat soil. Humic acid can potentially be used as an anti-inflammatory compound. This study aimed to determine the effect of humic acid on the volume of foot mice edema and to find the best dose that can suppress the degree of edema volume. The animal object was Swiss mice weighing 25-30 grams and 3 months old. The study used Randomized Block Design (RBD) with positive control, negative control and humic acid treatment with dose 62.5 mg kg-1BW, 125 mg kg-1BW, and 250 mg kg-1BW. The result of this research showed that edema inhibition by the administration of humic acid dose 62,5; 125; 250 mg kg-1 had inflammatory inhibition percentage 2.67%, 13.34%, and 20.01% respectively in 5-hour observation. The best dose of humic acid to suppress inflammation in the mice's paw is a humic acid dose of 250 mg kg-1 compared with value 23.3% of sodium diclofenac as the positive control. |
topic |
humic acid peat edema carrageenan |
url |
https://jurnal.ugm.ac.id/TradMedJ/article/view/48003 |
work_keys_str_mv |
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