Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53.

Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53.

DNA double-strand breaks (DSBs) represent one of the most deleterious forms of DNA damage to a cell. In cancer therapy, induction of cell death by DNA DSBs by ionizing radiation (IR) and certain chemotherapies is thought to mediate the successful elimination of cancer cells. However, cancer cells of...

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Bibliographic Details
Main Authors: Shelly Sorrells, Seth Carbonneau, Erik Harrington, Aye T Chen, Bridgid Hast, Brett Milash, Ujwal Pyati, Michael B Major, Yi Zhou, Leonard I Zon, Rodney A Stewart, A Thomas Look, Cicely Jette
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3431329?pdf=render

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