Highly Flexible Precisely Braided Multielectrode Probes and Combinatorics for Future Neuroprostheses
The braided multielectrode probe (BMEP) is an ultrafine microwire bundle interwoven into a precise tubular braided structure, which is designed to be used as an invasive neural probe consisting of multiple microelectrodes for electrophysiological neural recording and stimulation. Significant advanta...
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doaj-1b9de749c6e6409e817fd312f21dd56d2020-11-25T00:47:19ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-06-011310.3389/fnins.2019.00613447802Highly Flexible Precisely Braided Multielectrode Probes and Combinatorics for Future NeuroprosthesesTaegyo Kim0Kendall Schmidt1Kendall Schmidt2Christopher Deemie3Joanna Wycech4Hualou Liang5Simon F. Giszter6Simon F. Giszter7Neurobiology and Anatomy Department, Drexel University College of Medicine, Philadelphia, PA, United StatesNeurobiology and Anatomy Department, Drexel University College of Medicine, Philadelphia, PA, United StatesSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, United StatesNeurobiology and Anatomy Department, Drexel University College of Medicine, Philadelphia, PA, United StatesSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, United StatesSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, United StatesNeurobiology and Anatomy Department, Drexel University College of Medicine, Philadelphia, PA, United StatesSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, United StatesThe braided multielectrode probe (BMEP) is an ultrafine microwire bundle interwoven into a precise tubular braided structure, which is designed to be used as an invasive neural probe consisting of multiple microelectrodes for electrophysiological neural recording and stimulation. Significant advantages of BMEPs include highly flexible mechanical properties leading to decreased immune responses after chronic implantation in neural tissue and dense recording/stimulation sites (24 channels) within the 100–200 μm diameter. In addition, because BMEPs can be manufactured using various materials in any size and shape without length limitations, they could be expanded to applications in deep central nervous system (CNS) regions as well as peripheral nervous system (PNS) in larger animals and humans. Finally, the 3D topology of wires supports combinatoric rearrangements of wires within braids, and potential neural yield increases. With the newly developed next generation micro braiding machine, we can manufacture more precise and complex microbraid structures. In this article, we describe the new machine and methods, and tests of simulated combinatoric separation methods. We propose various promising BMEP designs and the potential modifications to these designs to create probes suitable for various applications for future neuroprostheses.https://www.frontiersin.org/article/10.3389/fnins.2019.00613/fullbraidmicroelectrodesneural implantsneural interfacesneuroprosthesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Taegyo Kim Kendall Schmidt Kendall Schmidt Christopher Deemie Joanna Wycech Hualou Liang Simon F. Giszter Simon F. Giszter |
spellingShingle |
Taegyo Kim Kendall Schmidt Kendall Schmidt Christopher Deemie Joanna Wycech Hualou Liang Simon F. Giszter Simon F. Giszter Highly Flexible Precisely Braided Multielectrode Probes and Combinatorics for Future Neuroprostheses Frontiers in Neuroscience braid microelectrodes neural implants neural interfaces neuroprosthesis |
author_facet |
Taegyo Kim Kendall Schmidt Kendall Schmidt Christopher Deemie Joanna Wycech Hualou Liang Simon F. Giszter Simon F. Giszter |
author_sort |
Taegyo Kim |
title |
Highly Flexible Precisely Braided Multielectrode Probes and Combinatorics for Future Neuroprostheses |
title_short |
Highly Flexible Precisely Braided Multielectrode Probes and Combinatorics for Future Neuroprostheses |
title_full |
Highly Flexible Precisely Braided Multielectrode Probes and Combinatorics for Future Neuroprostheses |
title_fullStr |
Highly Flexible Precisely Braided Multielectrode Probes and Combinatorics for Future Neuroprostheses |
title_full_unstemmed |
Highly Flexible Precisely Braided Multielectrode Probes and Combinatorics for Future Neuroprostheses |
title_sort |
highly flexible precisely braided multielectrode probes and combinatorics for future neuroprostheses |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2019-06-01 |
description |
The braided multielectrode probe (BMEP) is an ultrafine microwire bundle interwoven into a precise tubular braided structure, which is designed to be used as an invasive neural probe consisting of multiple microelectrodes for electrophysiological neural recording and stimulation. Significant advantages of BMEPs include highly flexible mechanical properties leading to decreased immune responses after chronic implantation in neural tissue and dense recording/stimulation sites (24 channels) within the 100–200 μm diameter. In addition, because BMEPs can be manufactured using various materials in any size and shape without length limitations, they could be expanded to applications in deep central nervous system (CNS) regions as well as peripheral nervous system (PNS) in larger animals and humans. Finally, the 3D topology of wires supports combinatoric rearrangements of wires within braids, and potential neural yield increases. With the newly developed next generation micro braiding machine, we can manufacture more precise and complex microbraid structures. In this article, we describe the new machine and methods, and tests of simulated combinatoric separation methods. We propose various promising BMEP designs and the potential modifications to these designs to create probes suitable for various applications for future neuroprostheses. |
topic |
braid microelectrodes neural implants neural interfaces neuroprosthesis |
url |
https://www.frontiersin.org/article/10.3389/fnins.2019.00613/full |
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