The association between pre-miR-27a rs895819 polymorphism and myocardial infarction risk in a Chinese Han population
Abstract Background Accumulating evidences have shown that miRNAs are directly or indirectly involved in a variety of biological processes, and closely associated with diverse human diseases, including cardiovascular diseases. SNPs locating within pri/pre-miRNA can affect miRNA processing and bindin...
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doaj-1b9fa9cf5eed419586c33c12b30e3b6b2020-11-25T00:55:21ZengBMCLipids in Health and Disease1476-511X2018-01-011711810.1186/s12944-017-0652-xThe association between pre-miR-27a rs895819 polymorphism and myocardial infarction risk in a Chinese Han populationMeng-yun Cai0Jie Cheng1Meng-yuan Zhou2Li-li Liang3Si-min Lian4Xiao-shan Xie5Shun Xu6Xinguang Liu7Xing-dong Xiong8Institute of Aging Research, Guangdong Medical UniversityInstitute of Aging Research, Guangdong Medical UniversityInstitute of Aging Research, Guangdong Medical UniversityInstitute of Aging Research, Guangdong Medical UniversityInstitute of Aging Research, Guangdong Medical UniversityInstitute of Aging Research, Guangdong Medical UniversityInstitute of Aging Research, Guangdong Medical UniversityInstitute of Aging Research, Guangdong Medical UniversityInstitute of Aging Research, Guangdong Medical UniversityAbstract Background Accumulating evidences have shown that miRNAs are directly or indirectly involved in a variety of biological processes, and closely associated with diverse human diseases, including cardiovascular diseases. SNPs locating within pri/pre-miRNA can affect miRNA processing and binding ability of target genes. MiR-27a, miR-26a-1 miR-100, miR-126 and miR-218 were reported to be associated with pathogenesis of myocardial infarction (MI). Here we aimed to evaluate the potential association of five polymorphisms in these pri/pre-miRNAs with individual susceptibility to MI in a Chinese Han population. Methods Genotyping was performed in 287 MI cases and 646 control subjects using polymerase chain reaction-ligase detection reaction (PCR-LDR) method. The association of these SNPs with MI risk was performed with SPSS software. Results In a logistic regression analysis, we found that AG heterozygote (OR = 0.40, 95% CI = 0.21-0.76, Pa = 0.005) or AA homozygote (OR = 0.40, 95% CI = 0.22-0.75, Pa = 0.004) of pre-miR-27a rs895819 had a reduced susceptibility to MI in comparison with GG homozygote. Similarly, a reduced risk of MI was detected when the AG and AA genotypes were combined (OR = 0.40, 95% CI = 0.22-0.74, Pa = 0.003). However, no significant association between pri-miR-26a-1 pri-miR-100, pri-miR-126 and pri-miR-218 polymorphisms and MI risk was observed under the allelic and established genetic models. Further stratified analysis of pre-miR-27a rs895819 revealed a more significant association of AG + AA genotypes with MI risk among younger, male and smoking subjects. Interestingly, AG and AA genotypes of the rs895819 polymorphism conferred about 0.17 mmol/L and 0.18 mmol/L increase in HDL-C levels compared to GG genotype. Conclusions Our findings suggest that the pre-miR-27a rs895819 polymorphism is associated with MI susceptibility in the Chinese Han population, which probably due to influence the HDL-C levels.http://link.springer.com/article/10.1186/s12944-017-0652-xmiR-27aSingle nucleotide polymorphismrs895819Myocardial infarctionDisease susceptibility |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Meng-yun Cai Jie Cheng Meng-yuan Zhou Li-li Liang Si-min Lian Xiao-shan Xie Shun Xu Xinguang Liu Xing-dong Xiong |
spellingShingle |
Meng-yun Cai Jie Cheng Meng-yuan Zhou Li-li Liang Si-min Lian Xiao-shan Xie Shun Xu Xinguang Liu Xing-dong Xiong The association between pre-miR-27a rs895819 polymorphism and myocardial infarction risk in a Chinese Han population Lipids in Health and Disease miR-27a Single nucleotide polymorphism rs895819 Myocardial infarction Disease susceptibility |
author_facet |
Meng-yun Cai Jie Cheng Meng-yuan Zhou Li-li Liang Si-min Lian Xiao-shan Xie Shun Xu Xinguang Liu Xing-dong Xiong |
author_sort |
Meng-yun Cai |
title |
The association between pre-miR-27a rs895819 polymorphism and myocardial infarction risk in a Chinese Han population |
title_short |
The association between pre-miR-27a rs895819 polymorphism and myocardial infarction risk in a Chinese Han population |
title_full |
The association between pre-miR-27a rs895819 polymorphism and myocardial infarction risk in a Chinese Han population |
title_fullStr |
The association between pre-miR-27a rs895819 polymorphism and myocardial infarction risk in a Chinese Han population |
title_full_unstemmed |
The association between pre-miR-27a rs895819 polymorphism and myocardial infarction risk in a Chinese Han population |
title_sort |
association between pre-mir-27a rs895819 polymorphism and myocardial infarction risk in a chinese han population |
publisher |
BMC |
series |
Lipids in Health and Disease |
issn |
1476-511X |
publishDate |
2018-01-01 |
description |
Abstract Background Accumulating evidences have shown that miRNAs are directly or indirectly involved in a variety of biological processes, and closely associated with diverse human diseases, including cardiovascular diseases. SNPs locating within pri/pre-miRNA can affect miRNA processing and binding ability of target genes. MiR-27a, miR-26a-1 miR-100, miR-126 and miR-218 were reported to be associated with pathogenesis of myocardial infarction (MI). Here we aimed to evaluate the potential association of five polymorphisms in these pri/pre-miRNAs with individual susceptibility to MI in a Chinese Han population. Methods Genotyping was performed in 287 MI cases and 646 control subjects using polymerase chain reaction-ligase detection reaction (PCR-LDR) method. The association of these SNPs with MI risk was performed with SPSS software. Results In a logistic regression analysis, we found that AG heterozygote (OR = 0.40, 95% CI = 0.21-0.76, Pa = 0.005) or AA homozygote (OR = 0.40, 95% CI = 0.22-0.75, Pa = 0.004) of pre-miR-27a rs895819 had a reduced susceptibility to MI in comparison with GG homozygote. Similarly, a reduced risk of MI was detected when the AG and AA genotypes were combined (OR = 0.40, 95% CI = 0.22-0.74, Pa = 0.003). However, no significant association between pri-miR-26a-1 pri-miR-100, pri-miR-126 and pri-miR-218 polymorphisms and MI risk was observed under the allelic and established genetic models. Further stratified analysis of pre-miR-27a rs895819 revealed a more significant association of AG + AA genotypes with MI risk among younger, male and smoking subjects. Interestingly, AG and AA genotypes of the rs895819 polymorphism conferred about 0.17 mmol/L and 0.18 mmol/L increase in HDL-C levels compared to GG genotype. Conclusions Our findings suggest that the pre-miR-27a rs895819 polymorphism is associated with MI susceptibility in the Chinese Han population, which probably due to influence the HDL-C levels. |
topic |
miR-27a Single nucleotide polymorphism rs895819 Myocardial infarction Disease susceptibility |
url |
http://link.springer.com/article/10.1186/s12944-017-0652-x |
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