Sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients
Abstract Despite technological and immunological innovations, living-donor liver transplant (LDLT) recipients still face substantial risk of postoperative complications. Sarcopenia is being recognized more and more as a biomarker that correlates with poor outcomes in surgical patients. The purpose o...
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2021-09-01
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doaj-1ba8d145a0c74c419129d1af2b2c59c12021-10-03T11:34:29ZengNature Publishing GroupScientific Reports2045-23222021-09-011111810.1038/s41598-021-98399-6Sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipientsMei-Yun Wu0Wei-Xiong Lim1Yu-Fan Cheng2Ching-Di Chang3Hsien-Wen Hsu4Chih-Che Lin5Chao-Long Chen6Wan-Ching Chang7Chun-Yen Yu8Leo Leung-Chit Tsang9Yi-Hsuan Chuang10Hsin-You Ou11College of Nursing, Kaohsiung Medical UniversityDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineAbstract Despite technological and immunological innovations, living-donor liver transplant (LDLT) recipients still face substantial risk of postoperative complications. Sarcopenia is being recognized more and more as a biomarker that correlates with poor outcomes in surgical patients. The purpose of this study was to evaluate the relationship between sarcopenia and significant surgical complications in LDLT recipients. This retrospective review included patients who had received LDLT at our institute from 2005 to 2017. Sarcopenia was assessed using the psoas muscle index (PMI) in cross-sectional images. ROC curve analysis was used to determine the ability of PMI to predict postoperative complications. Correlations between major postoperative complications and sarcopenia were evaluated using regression analysis. A total of 271 LDLT recipients were included. No significant differences were found between PMI and major postoperative complications in male patients. Female recipients with major postoperative complications had significantly lower mean PMI values (P = 0.028), and the PMI cut-off value was 2.63 cm2/m2. Postoperative massive pleural effusion requiring pigtail drainage occurred more frequently in the sarcopenia group than in the non-sarcopenia group (P = 0.003). 1-, 3-, 5- and 10-year overall survival rates in female were significantly poorer in the sarcopenia group (n = 14) compared with the non-sarcopenia group (n = 108), at 92.9% versus 97.2%, 85.7% versus 95.4%, 85.7% versus 92.5% and 70.1 versus 82.0%, respectively (P = 0.041) and 94.6%, 89.9%, 85.9% and 78.5% in male patients. Sarcopenia is associated with a significantly higher risk of major postoperative complications in females. PMI and sarcopenia together are predictive of major postoperative complications and survival rates in female LDLT recipients.https://doi.org/10.1038/s41598-021-98399-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mei-Yun Wu Wei-Xiong Lim Yu-Fan Cheng Ching-Di Chang Hsien-Wen Hsu Chih-Che Lin Chao-Long Chen Wan-Ching Chang Chun-Yen Yu Leo Leung-Chit Tsang Yi-Hsuan Chuang Hsin-You Ou |
spellingShingle |
Mei-Yun Wu Wei-Xiong Lim Yu-Fan Cheng Ching-Di Chang Hsien-Wen Hsu Chih-Che Lin Chao-Long Chen Wan-Ching Chang Chun-Yen Yu Leo Leung-Chit Tsang Yi-Hsuan Chuang Hsin-You Ou Sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients Scientific Reports |
author_facet |
Mei-Yun Wu Wei-Xiong Lim Yu-Fan Cheng Ching-Di Chang Hsien-Wen Hsu Chih-Che Lin Chao-Long Chen Wan-Ching Chang Chun-Yen Yu Leo Leung-Chit Tsang Yi-Hsuan Chuang Hsin-You Ou |
author_sort |
Mei-Yun Wu |
title |
Sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients |
title_short |
Sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients |
title_full |
Sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients |
title_fullStr |
Sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients |
title_full_unstemmed |
Sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients |
title_sort |
sarcopenia adversely impacts postoperative complications in living-donor liver transplantation recipients |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-09-01 |
description |
Abstract Despite technological and immunological innovations, living-donor liver transplant (LDLT) recipients still face substantial risk of postoperative complications. Sarcopenia is being recognized more and more as a biomarker that correlates with poor outcomes in surgical patients. The purpose of this study was to evaluate the relationship between sarcopenia and significant surgical complications in LDLT recipients. This retrospective review included patients who had received LDLT at our institute from 2005 to 2017. Sarcopenia was assessed using the psoas muscle index (PMI) in cross-sectional images. ROC curve analysis was used to determine the ability of PMI to predict postoperative complications. Correlations between major postoperative complications and sarcopenia were evaluated using regression analysis. A total of 271 LDLT recipients were included. No significant differences were found between PMI and major postoperative complications in male patients. Female recipients with major postoperative complications had significantly lower mean PMI values (P = 0.028), and the PMI cut-off value was 2.63 cm2/m2. Postoperative massive pleural effusion requiring pigtail drainage occurred more frequently in the sarcopenia group than in the non-sarcopenia group (P = 0.003). 1-, 3-, 5- and 10-year overall survival rates in female were significantly poorer in the sarcopenia group (n = 14) compared with the non-sarcopenia group (n = 108), at 92.9% versus 97.2%, 85.7% versus 95.4%, 85.7% versus 92.5% and 70.1 versus 82.0%, respectively (P = 0.041) and 94.6%, 89.9%, 85.9% and 78.5% in male patients. Sarcopenia is associated with a significantly higher risk of major postoperative complications in females. PMI and sarcopenia together are predictive of major postoperative complications and survival rates in female LDLT recipients. |
url |
https://doi.org/10.1038/s41598-021-98399-6 |
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