Study Progression of Apelin/APJ Signaling and Apela in Different Types of Cancer

Apelin is an endogenous ligand that binds to the G protein-coupled receptor angiotensin-like-receptor 1 (APJ). Apelin and APJ are widely distributed in organs and tissues and are involved in multiple physiological and pathological processes including cardiovascular regulation, neuroendocrine stress...

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Main Authors:	Longfei Liu, Xiaoping Yi, Can Lu, Yong Wang, Qiao Xiao, Liang Zhang, Yingxian Pang, Xiao Guan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-04-01
Series:	Frontiers in Oncology
Subjects:	apelin APJ Apela cancer therapeutic targets
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2021.658253/full

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spelling	doaj-1baa585eb2b6407a9ca688f48e090f2c2021-04-12T05:38:18ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-04-011110.3389/fonc.2021.658253658253Study Progression of Apelin/APJ Signaling and Apela in Different Types of CancerLongfei Liu0Xiaoping Yi1Can Lu2Yong Wang3Qiao Xiao4Liang Zhang5Yingxian Pang6Xiao Guan7Department of Urology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Urology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Urology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Urology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Urology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Urology, Xiangya Hospital, Central South University, Changsha, ChinaApelin is an endogenous ligand that binds to the G protein-coupled receptor angiotensin-like-receptor 1 (APJ). Apelin and APJ are widely distributed in organs and tissues and are involved in multiple physiological and pathological processes including cardiovascular regulation, neuroendocrine stress response, energy metabolism, etc. Additionally, apelin/APJ axis was found to play an important role in cancer development and progression. Apela is a newly identified endogenous ligand for APJ. Several studies have revealed the potential role of Apela in cancers. In this article, we review the current studies focusing on the role of apelin/APJ signaling and Apela in different cancers. Potential mechanisms by which apelin/APJ and Apela mediate the regulation of cancer development and progression were also mentioned. The Apelin/APJ signaling and Apela may serve as potential therapeutic candidates for treatment of cancer.https://www.frontiersin.org/articles/10.3389/fonc.2021.658253/fullapelinAPJApelacancertherapeutic targets
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Longfei Liu Xiaoping Yi Can Lu Yong Wang Qiao Xiao Liang Zhang Yingxian Pang Xiao Guan
spellingShingle	Longfei Liu Xiaoping Yi Can Lu Yong Wang Qiao Xiao Liang Zhang Yingxian Pang Xiao Guan Study Progression of Apelin/APJ Signaling and Apela in Different Types of Cancer Frontiers in Oncology apelin APJ Apela cancer therapeutic targets
author_facet	Longfei Liu Xiaoping Yi Can Lu Yong Wang Qiao Xiao Liang Zhang Yingxian Pang Xiao Guan
author_sort	Longfei Liu
title	Study Progression of Apelin/APJ Signaling and Apela in Different Types of Cancer
title_short	Study Progression of Apelin/APJ Signaling and Apela in Different Types of Cancer
title_full	Study Progression of Apelin/APJ Signaling and Apela in Different Types of Cancer
title_fullStr	Study Progression of Apelin/APJ Signaling and Apela in Different Types of Cancer
title_full_unstemmed	Study Progression of Apelin/APJ Signaling and Apela in Different Types of Cancer
title_sort	study progression of apelin/apj signaling and apela in different types of cancer
publisher	Frontiers Media S.A.
series	Frontiers in Oncology
issn	2234-943X
publishDate	2021-04-01
description	Apelin is an endogenous ligand that binds to the G protein-coupled receptor angiotensin-like-receptor 1 (APJ). Apelin and APJ are widely distributed in organs and tissues and are involved in multiple physiological and pathological processes including cardiovascular regulation, neuroendocrine stress response, energy metabolism, etc. Additionally, apelin/APJ axis was found to play an important role in cancer development and progression. Apela is a newly identified endogenous ligand for APJ. Several studies have revealed the potential role of Apela in cancers. In this article, we review the current studies focusing on the role of apelin/APJ signaling and Apela in different cancers. Potential mechanisms by which apelin/APJ and Apela mediate the regulation of cancer development and progression were also mentioned. The Apelin/APJ signaling and Apela may serve as potential therapeutic candidates for treatment of cancer.
topic	apelin APJ Apela cancer therapeutic targets
url	https://www.frontiersin.org/articles/10.3389/fonc.2021.658253/full
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Study Progression of Apelin/APJ Signaling and Apela in Different Types of Cancer

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