Early Covert Appearance of Marginal Zone B Cells in Salivary Glands of Sjögren′s Syndrome-Susceptible Mice: Initiators of Subsequent Overt Clinical Disease

Early Covert Appearance of Marginal Zone B Cells in Salivary Glands of Sjögren′s Syndrome-Susceptible Mice: Initiators of Subsequent Overt Clinical Disease

The C57BL/6.NOD-<i>Aec1Aec2</i> mouse model has been extensively studied to define the underlying cellular and molecular bioprocesses critical in the onset of primary Sjögren’s Syndrome (pSS), a human systemic autoimmune disease characterized clinically as the loss of lacrimal and saliva...

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Bibliographic Details
Main Authors: Ammon B. Peck, Cuong Q. Nguyen, Julian Ambrus
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
Sjögren´s syndrome
C57BL/6.NOD-<i>Aec1Aec2</i> mice
marginal zones (MZ), marginal zone B (MZB) cells
Notch2
B cell receptor (BCR), sphingosine-1-phosphate (S1P), sphingosine-1-phosphate receptor (S1PR), RNA transcriptome microarrays.
Online Access:https://www.mdpi.com/1422-0067/22/4/1919

Internet

https://www.mdpi.com/1422-0067/22/4/1919

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