Data on the association of CMPK1 with clinicopathological features and biological effect in human epithelial ovarian cancer

Data on the association of CMPK1 with clinicopathological features and biological effect in human epithelial ovarian cancer

Human epithelial ovarian cancer (EOC) is the most lethal gynecological disease. However, the molecular mechanisms by which transforming growth factor-β (TGF-β) regulates ovarian tumor progression markers remain unclear. The present data show cytidine monophosphate kinase (CMPK) as an EOC biomarker a...

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Main Authors: Daibing Zhou, Lingyun Zhang, Qunbo Lin, Weimin Ren, Guoxiong Xu
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Data in Brief
Online Access:http://www.sciencedirect.com/science/article/pii/S2352340917302135
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spelling doaj-1bc43badf92b4859b849e885362796be2020-11-25T00:43:24ZengElsevierData in Brief2352-34092017-08-01137784Data on the association of CMPK1 with clinicopathological features and biological effect in human epithelial ovarian cancerDaibing Zhou0Lingyun Zhang1Qunbo Lin2Weimin Ren3Guoxiong Xu4Center Laboratory, Jinshan Hospital, Fudan University, Shanghai 201508, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaCenter Laboratory, Jinshan Hospital, Fudan University, Shanghai 201508, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaCenter Laboratory, Jinshan Hospital, Fudan University, Shanghai 201508, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaCenter Laboratory, Jinshan Hospital, Fudan University, Shanghai 201508, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaCenter Laboratory, Jinshan Hospital, Fudan University, Shanghai 201508, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Corresponding author at: Center Laboratory, Jinshan Hospital, Fudan University, Shanghai 201508, China.Human epithelial ovarian cancer (EOC) is the most lethal gynecological disease. However, the molecular mechanisms by which transforming growth factor-β (TGF-β) regulates ovarian tumor progression markers remain unclear. The present data show cytidine monophosphate kinase (CMPK) as an EOC biomarker and are related to the article entitled “Cytidine monophosphate kinase is inhibited by the TGF-β signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer” [1]. CMPK, as well as cystatin B [2] and β-2-microglobulin [3], is overexpressed in human epithelial-type ovarian tumors. CMPK is an enzyme required for nucleic acid biosynthesis [4] and is regulated by the TGF-β signaling pathway in EOC cells [1]. Furthermore, the data show the effect of CMPK-shRNA on EOC cell apoptosis and TGF-β-induced Smad2 phosphorylation. CMPK expression in two EOC cell lines OVCAR-3 and SK-OV-3 is regulated by multiple miRNAs and some of these miRNAs may affect EOC chemoresistance [5]. Keywords: TGF-β signaling, UMP/CMP kinase, Tissue microarray, Tumorigenesis, miRNA, Therapeutic targethttp://www.sciencedirect.com/science/article/pii/S2352340917302135
collection DOAJ
language English
format Article
sources DOAJ
author Daibing Zhou
Lingyun Zhang
Qunbo Lin
Weimin Ren
Guoxiong Xu
spellingShingle Daibing Zhou
Lingyun Zhang
Qunbo Lin
Weimin Ren
Guoxiong Xu
Data on the association of CMPK1 with clinicopathological features and biological effect in human epithelial ovarian cancer
Data in Brief
author_facet Daibing Zhou
Lingyun Zhang
Qunbo Lin
Weimin Ren
Guoxiong Xu
author_sort Daibing Zhou
title Data on the association of CMPK1 with clinicopathological features and biological effect in human epithelial ovarian cancer
title_short Data on the association of CMPK1 with clinicopathological features and biological effect in human epithelial ovarian cancer
title_full Data on the association of CMPK1 with clinicopathological features and biological effect in human epithelial ovarian cancer
title_fullStr Data on the association of CMPK1 with clinicopathological features and biological effect in human epithelial ovarian cancer
title_full_unstemmed Data on the association of CMPK1 with clinicopathological features and biological effect in human epithelial ovarian cancer
title_sort data on the association of cmpk1 with clinicopathological features and biological effect in human epithelial ovarian cancer
publisher Elsevier
series Data in Brief
issn 2352-3409
publishDate 2017-08-01
description Human epithelial ovarian cancer (EOC) is the most lethal gynecological disease. However, the molecular mechanisms by which transforming growth factor-β (TGF-β) regulates ovarian tumor progression markers remain unclear. The present data show cytidine monophosphate kinase (CMPK) as an EOC biomarker and are related to the article entitled “Cytidine monophosphate kinase is inhibited by the TGF-β signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer” [1]. CMPK, as well as cystatin B [2] and β-2-microglobulin [3], is overexpressed in human epithelial-type ovarian tumors. CMPK is an enzyme required for nucleic acid biosynthesis [4] and is regulated by the TGF-β signaling pathway in EOC cells [1]. Furthermore, the data show the effect of CMPK-shRNA on EOC cell apoptosis and TGF-β-induced Smad2 phosphorylation. CMPK expression in two EOC cell lines OVCAR-3 and SK-OV-3 is regulated by multiple miRNAs and some of these miRNAs may affect EOC chemoresistance [5]. Keywords: TGF-β signaling, UMP/CMP kinase, Tissue microarray, Tumorigenesis, miRNA, Therapeutic target
url http://www.sciencedirect.com/science/article/pii/S2352340917302135
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