Sulprostone-Induced Gastric Dysrhythmia in the Ferret: Conventional and Advanced Analytical Approaches
Nausea and emesis resulting from disease or drug treatment may be associated with disrupted gastric myoelectric activity (GMA). Conventional analytical techniques can determine the relative degrees of brady-, normo-, and tachygastric power, but lose information relative to the basic slow wave shape....
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Frontiers Media S.A.
2021-01-01
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Series: | Frontiers in Physiology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2020.583082/full |
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doaj-1bd3840da96441499db880ff785da2bb |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zengbing Lu Zengbing Lu Yu Zhou Longlong Tu Sze Wa Chan Man P. Ngan Dexuan Cui Yuen Hang Julia Liu Ianto Bosheng Huang Jeng S. C. Kung Chung Man Jessica Hui John A. Rudd John A. Rudd |
spellingShingle |
Zengbing Lu Zengbing Lu Yu Zhou Longlong Tu Sze Wa Chan Man P. Ngan Dexuan Cui Yuen Hang Julia Liu Ianto Bosheng Huang Jeng S. C. Kung Chung Man Jessica Hui John A. Rudd John A. Rudd Sulprostone-Induced Gastric Dysrhythmia in the Ferret: Conventional and Advanced Analytical Approaches Frontiers in Physiology sulprostone ferret gastric myoelectric activity running spectrum analysis detrended fluctuation analysis entropy |
author_facet |
Zengbing Lu Zengbing Lu Yu Zhou Longlong Tu Sze Wa Chan Man P. Ngan Dexuan Cui Yuen Hang Julia Liu Ianto Bosheng Huang Jeng S. C. Kung Chung Man Jessica Hui John A. Rudd John A. Rudd |
author_sort |
Zengbing Lu |
title |
Sulprostone-Induced Gastric Dysrhythmia in the Ferret: Conventional and Advanced Analytical Approaches |
title_short |
Sulprostone-Induced Gastric Dysrhythmia in the Ferret: Conventional and Advanced Analytical Approaches |
title_full |
Sulprostone-Induced Gastric Dysrhythmia in the Ferret: Conventional and Advanced Analytical Approaches |
title_fullStr |
Sulprostone-Induced Gastric Dysrhythmia in the Ferret: Conventional and Advanced Analytical Approaches |
title_full_unstemmed |
Sulprostone-Induced Gastric Dysrhythmia in the Ferret: Conventional and Advanced Analytical Approaches |
title_sort |
sulprostone-induced gastric dysrhythmia in the ferret: conventional and advanced analytical approaches |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2021-01-01 |
description |
Nausea and emesis resulting from disease or drug treatment may be associated with disrupted gastric myoelectric activity (GMA). Conventional analytical techniques can determine the relative degrees of brady-, normo-, and tachygastric power, but lose information relative to the basic slow wave shape. The aim of the present study was to investigate the application of advanced analytical techniques in the analysis of disrupted GMA recorded after administration of sulprostone, a prostaglandin E3/1 agonist, in ferrets. Ferrets were implanted with radiotelemetry devices to record GMA, blood pressure, heart rate (HR) and core body temperature 1 week before the administration of sulprostone (30 μg/kg) or vehicle (saline, 0.5 mL/kg). GMA was initially analyzed using fast Fourier transformations (FFTs) and a conventional power partitioning. Detrended fluctuation analysis (DFA) was also applied to the GMA recordings to reveal information relative to the fluctuation of signals around local trends. Sample entropy (SampEn) analysis was used for examining the regularity of signals. Conventional signal processing techniques revealed that sulprostone increased the dominant frequency (DF) of slow waves, with an increase in the percentage power of the tachygastric range and a decrease in the percentage power of the normogastric range. DFA revealed that sulprostone decreased the fluctuation function, indicative of a loss of the variability of GMA fluctuations around local trends. Sulprostone increased SampEn values, indicating a loss of regularity in the GMA data. Behaviorally, sulprostone induced emesis and caused defecation. It also increased blood pressure and elevated HR, with an associated decrease in HR variability (HRV). Further analysis of HRV revealed a decrease in both low-frequency (LF) and high-frequency (HF) components, with an overall increase in the LF/HF ratio. Sulprostone did not affect core body temperature. In conclusion, DFA and SampEn permit a detailed analysis of GMA, which is necessary to understand the action of sulprostone to modulate gastric function. The action to decrease HRV and increase the LF/HF ratio may be consistent with a shift toward sympathetic nervous system dominance, commonly seen during nausea. |
topic |
sulprostone ferret gastric myoelectric activity running spectrum analysis detrended fluctuation analysis entropy |
url |
https://www.frontiersin.org/articles/10.3389/fphys.2020.583082/full |
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doaj-1bd3840da96441499db880ff785da2bb2021-01-08T06:50:26ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-01-011110.3389/fphys.2020.583082583082Sulprostone-Induced Gastric Dysrhythmia in the Ferret: Conventional and Advanced Analytical ApproachesZengbing Lu0Zengbing Lu1Yu Zhou2Longlong Tu3Sze Wa Chan4Man P. Ngan5Dexuan Cui6Yuen Hang Julia Liu7Ianto Bosheng Huang8Jeng S. C. Kung9Chung Man Jessica Hui10John A. Rudd11John A. Rudd12School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong KongSchool of Health Sciences, Caritas Institute of Higher Education, Tseung Kwan O New Town, Hong KongInstitute of Future Cities, The Chinese University of Hong Kong, Shatin, Hong KongSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong KongSchool of Health Sciences, Caritas Institute of Higher Education, Tseung Kwan O New Town, Hong KongSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong KongSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong KongSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong KongSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong KongSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong KongSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong KongSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong KongLaboratory Animal Services Centre, The Chinese University of Hong Kong, Shatin, Hong KongNausea and emesis resulting from disease or drug treatment may be associated with disrupted gastric myoelectric activity (GMA). Conventional analytical techniques can determine the relative degrees of brady-, normo-, and tachygastric power, but lose information relative to the basic slow wave shape. The aim of the present study was to investigate the application of advanced analytical techniques in the analysis of disrupted GMA recorded after administration of sulprostone, a prostaglandin E3/1 agonist, in ferrets. Ferrets were implanted with radiotelemetry devices to record GMA, blood pressure, heart rate (HR) and core body temperature 1 week before the administration of sulprostone (30 μg/kg) or vehicle (saline, 0.5 mL/kg). GMA was initially analyzed using fast Fourier transformations (FFTs) and a conventional power partitioning. Detrended fluctuation analysis (DFA) was also applied to the GMA recordings to reveal information relative to the fluctuation of signals around local trends. Sample entropy (SampEn) analysis was used for examining the regularity of signals. Conventional signal processing techniques revealed that sulprostone increased the dominant frequency (DF) of slow waves, with an increase in the percentage power of the tachygastric range and a decrease in the percentage power of the normogastric range. DFA revealed that sulprostone decreased the fluctuation function, indicative of a loss of the variability of GMA fluctuations around local trends. Sulprostone increased SampEn values, indicating a loss of regularity in the GMA data. Behaviorally, sulprostone induced emesis and caused defecation. It also increased blood pressure and elevated HR, with an associated decrease in HR variability (HRV). Further analysis of HRV revealed a decrease in both low-frequency (LF) and high-frequency (HF) components, with an overall increase in the LF/HF ratio. Sulprostone did not affect core body temperature. In conclusion, DFA and SampEn permit a detailed analysis of GMA, which is necessary to understand the action of sulprostone to modulate gastric function. The action to decrease HRV and increase the LF/HF ratio may be consistent with a shift toward sympathetic nervous system dominance, commonly seen during nausea.https://www.frontiersin.org/articles/10.3389/fphys.2020.583082/fullsulprostoneferretgastric myoelectric activityrunning spectrum analysisdetrended fluctuation analysisentropy |