ANX7 as a Bio-Marker in Prostate and Breast Cancer Progression

ANX7 as a Bio-Marker in Prostate and Breast Cancer Progression

The ANX7 gene codes for a Ca2+-activated GTPase, which has been implicated in both exocytotic secretion in cells and control of growth. In this review, we summarize information regarding increased tumor frequency in the Anx7 knockout mice, ANX7 growth suppression of human cancer cell lines, and ANX7...

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Main Authors: Meera Srivastava, Lukas Bubendorf, Lisa Nolan, Mirta Glasman, Ximena Leighton, Georgina Miller, Wilfred Fehrle, Mark Raffeld, Ofer Eidelman, Olli P. Kallioniemi, Shiv Srivastava, Harvey B. Pollard
Format: Article
Language:English
Published: Hindawi Limited 2001-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.1155/2001/239602
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spelling doaj-1bdaa3acd61844488277d5635dceaf422020-11-24T21:57:23ZengHindawi LimitedDisease Markers0278-02401875-86302001-01-0117211512010.1155/2001/239602ANX7 as a Bio-Marker in Prostate and Breast Cancer ProgressionMeera Srivastava0Lukas Bubendorf1Lisa Nolan2Mirta Glasman3Ximena Leighton4Georgina Miller5Wilfred Fehrle6Mark Raffeld7Ofer Eidelman8Olli P. Kallioniemi9Shiv Srivastava10Harvey B. Pollard11Department of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine (USUHS), Bethesda, MD 20814, USASection on Molecular Genetics, Cancer Genetics Branch, NHGRI, National Institutes of Health, Bethesda, MD 20892, USADepartment of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine (USUHS), Bethesda, MD 20814, USADepartment of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine (USUHS), Bethesda, MD 20814, USADepartment of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine (USUHS), Bethesda, MD 20814, USAVeterinary Resources Program, NCRR, National Institutes of Health, Bethesda, MD 20892, USALaboratory of Pathology, Hematopathology section, NCI, NIH, Bethesda, MD 20892, USALaboratory of Pathology, Hematopathology section, NCI, NIH, Bethesda, MD 20892, USADepartment of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine (USUHS), Bethesda, MD 20814, USASection on Molecular Genetics, Cancer Genetics Branch, NHGRI, National Institutes of Health, Bethesda, MD 20892, USACenter for Prostate Disease Research, and Department of Surgery, Uniformed Services University School of Medicine (USUHS), Bethesda, MD 20814, USADepartment of Anatomy, Physiology and Genetics, and Institute for Molecular Medicine, Uniformed Services University School of Medicine (USUHS), Bethesda, MD 20814, USAThe ANX7 gene codes for a Ca2+-activated GTPase, which has been implicated in both exocytotic secretion in cells and control of growth. In this review, we summarize information regarding increased tumor frequency in the Anx7 knockout mice, ANX7 growth suppression of human cancer cell lines, and ANX7 expression in human tumor tissue micro-arrays. The loss of ANX7 is significant in metastatic and hormone refractory prostate cancer compared to benign prostatic hyperplasia. In addition, ANX7 expression has prognostic value for predicting survival of breast cancer patients.http://dx.doi.org/10.1155/2001/239602
collection DOAJ
language English
format Article
sources DOAJ
author Meera Srivastava
Lukas Bubendorf
Lisa Nolan
Mirta Glasman
Ximena Leighton
Georgina Miller
Wilfred Fehrle
Mark Raffeld
Ofer Eidelman
Olli P. Kallioniemi
Shiv Srivastava
Harvey B. Pollard
spellingShingle Meera Srivastava
Lukas Bubendorf
Lisa Nolan
Mirta Glasman
Ximena Leighton
Georgina Miller
Wilfred Fehrle
Mark Raffeld
Ofer Eidelman
Olli P. Kallioniemi
Shiv Srivastava
Harvey B. Pollard
ANX7 as a Bio-Marker in Prostate and Breast Cancer Progression
Disease Markers
author_facet Meera Srivastava
Lukas Bubendorf
Lisa Nolan
Mirta Glasman
Ximena Leighton
Georgina Miller
Wilfred Fehrle
Mark Raffeld
Ofer Eidelman
Olli P. Kallioniemi
Shiv Srivastava
Harvey B. Pollard
author_sort Meera Srivastava
title ANX7 as a Bio-Marker in Prostate and Breast Cancer Progression
title_short ANX7 as a Bio-Marker in Prostate and Breast Cancer Progression
title_full ANX7 as a Bio-Marker in Prostate and Breast Cancer Progression
title_fullStr ANX7 as a Bio-Marker in Prostate and Breast Cancer Progression
title_full_unstemmed ANX7 as a Bio-Marker in Prostate and Breast Cancer Progression
title_sort anx7 as a bio-marker in prostate and breast cancer progression
publisher Hindawi Limited
series Disease Markers
issn 0278-0240
1875-8630
publishDate 2001-01-01
description The ANX7 gene codes for a Ca2+-activated GTPase, which has been implicated in both exocytotic secretion in cells and control of growth. In this review, we summarize information regarding increased tumor frequency in the Anx7 knockout mice, ANX7 growth suppression of human cancer cell lines, and ANX7 expression in human tumor tissue micro-arrays. The loss of ANX7 is significant in metastatic and hormone refractory prostate cancer compared to benign prostatic hyperplasia. In addition, ANX7 expression has prognostic value for predicting survival of breast cancer patients.
url http://dx.doi.org/10.1155/2001/239602
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