Antidiarrheal Activity of Three Medicinal Plants in Swiss Albino Mice
Background: Different parts of Allamanda neriifolia (AN), Crinum latifolium (CL), and Bruguiera cylindrical (BC) are used in folk medicine to treat diarrhea. Therefore, the aim of this study was to investigate and compare possible antidiarrheal activity of methanol extracts from barks, stems, and ro...
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doaj-1bdf2e1f6d304d4fad4253f53d6e10932020-11-24T23:18:50ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292016-09-016323323610.21103/Article6(3)_OA16Antidiarrheal Activity of Three Medicinal Plants in Swiss Albino MiceMD. Ashrafuzzaman0Golam Sarwar Raju1Muhammad Imam Uddin Abeer2Saifuddin Mohammad Seeam3Abu Zafor Mohammad Salahuddin4Dipti Debnath5H.M. Shadid Hossain Snigdha6Bhorhan Uddin Sawan7S. M. Masud Rana8Department of Biomedical Engineering, Military Institute of Science and Technology (MIST), Dhaka, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali, BangladeshDepartment of Biomedical Engineering, Military Institute of Science and Technology (MIST), Dhaka, BangladeshDepartment of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, BangladeshDepartment of Pharmacy, University of Rajshahi, Rajshahi, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, Noakhali, BangladeshDepartment of Biomedical Engineering, Military Institute of Science and Technology (MIST), Dhaka, BangladeshBackground: Different parts of Allamanda neriifolia (AN), Crinum latifolium (CL), and Bruguiera cylindrical (BC) are used in folk medicine to treat diarrhea. Therefore, the aim of this study was to investigate and compare possible antidiarrheal activity of methanol extracts from barks, stems, and roots of AL, CL, and BC in Swiss albino mice. Methods: Antidiarrheal activities of extracts were evaluated at three doses (100mg/kg, 200 mg/kg and 400mg/kg) and compared with Loperamide in a castor oil-induced diarrhea and charcoal meal test model in the Swiss albino mice. Results: The aqueous extract of CL and BC administered at doses of 100, 200 and 400mg/kg showed 0%, 24.5%, 62.26% and 5.66%, 37.11%, and 62.26% diarrhea inhibition, respectively (Table 2). This reduction in diarrheal episodes is significant, and maximum effect was observed at the dose of 400mg/kg similarly in the alcohol extracts of both CL and BC. AN administered at the dose of 100, 200 and 400mg/kg showed 55.97%, 74.84% and 74.84% diarrhea inhibition, respectively. Conclusion: The antidiarrheal effect of the AN extract, in contrast to CL and BC, against the castor oil-induced diarrhea model prove its efficacy in an extensive range of diarrheal conditions. http://ijbm.org/articles/IJBM_6(3)_OA16.pdfAllamanda neriifoliaCrinum latifoliumBruguiera cylindricalantidiarrheal activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
MD. Ashrafuzzaman Golam Sarwar Raju Muhammad Imam Uddin Abeer Saifuddin Mohammad Seeam Abu Zafor Mohammad Salahuddin Dipti Debnath H.M. Shadid Hossain Snigdha Bhorhan Uddin Sawan S. M. Masud Rana |
spellingShingle |
MD. Ashrafuzzaman Golam Sarwar Raju Muhammad Imam Uddin Abeer Saifuddin Mohammad Seeam Abu Zafor Mohammad Salahuddin Dipti Debnath H.M. Shadid Hossain Snigdha Bhorhan Uddin Sawan S. M. Masud Rana Antidiarrheal Activity of Three Medicinal Plants in Swiss Albino Mice International Journal of Biomedicine Allamanda neriifolia Crinum latifolium Bruguiera cylindrical antidiarrheal activity |
author_facet |
MD. Ashrafuzzaman Golam Sarwar Raju Muhammad Imam Uddin Abeer Saifuddin Mohammad Seeam Abu Zafor Mohammad Salahuddin Dipti Debnath H.M. Shadid Hossain Snigdha Bhorhan Uddin Sawan S. M. Masud Rana |
author_sort |
MD. Ashrafuzzaman |
title |
Antidiarrheal Activity of Three Medicinal Plants in Swiss Albino Mice |
title_short |
Antidiarrheal Activity of Three Medicinal Plants in Swiss Albino Mice |
title_full |
Antidiarrheal Activity of Three Medicinal Plants in Swiss Albino Mice |
title_fullStr |
Antidiarrheal Activity of Three Medicinal Plants in Swiss Albino Mice |
title_full_unstemmed |
Antidiarrheal Activity of Three Medicinal Plants in Swiss Albino Mice |
title_sort |
antidiarrheal activity of three medicinal plants in swiss albino mice |
publisher |
International Medical Research and Development Corporation |
series |
International Journal of Biomedicine |
issn |
2158-0510 2158-0529 |
publishDate |
2016-09-01 |
description |
Background: Different parts of Allamanda neriifolia (AN), Crinum latifolium (CL), and Bruguiera cylindrical (BC) are used in folk medicine to treat diarrhea. Therefore, the aim of this study was to investigate and compare possible antidiarrheal activity of methanol extracts from barks, stems, and roots of AL, CL, and BC in Swiss albino mice.
Methods: Antidiarrheal activities of extracts were evaluated at three doses (100mg/kg, 200 mg/kg and 400mg/kg) and compared with Loperamide in a castor oil-induced diarrhea and charcoal meal test model in the Swiss albino mice.
Results: The aqueous extract of CL and BC administered at doses of 100, 200 and 400mg/kg showed 0%, 24.5%, 62.26% and 5.66%, 37.11%, and 62.26% diarrhea inhibition, respectively (Table 2). This reduction in diarrheal episodes is significant, and maximum effect was observed at the dose of 400mg/kg similarly in the alcohol extracts of both CL and BC. AN administered at the dose of 100, 200 and 400mg/kg showed 55.97%, 74.84% and 74.84% diarrhea inhibition, respectively.
Conclusion: The antidiarrheal effect of the AN extract, in contrast to CL and BC, against the castor oil-induced diarrhea model prove its efficacy in an extensive range of diarrheal conditions.
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topic |
Allamanda neriifolia Crinum latifolium Bruguiera cylindrical antidiarrheal activity |
url |
http://ijbm.org/articles/IJBM_6(3)_OA16.pdf |
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