Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics
Glucagon-like peptide-1 receptor is an important regulator of appetite and glucose homeostasis. Here the authors describe super-resolution microscopy and in vivo imaging compatible fluorescent probes, which reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics in islets and br...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14309-w |
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doaj-1bec881e08194ff3b4ad84658e0675292021-05-11T08:04:31ZengNature Publishing GroupNature Communications2041-17232020-01-0111111810.1038/s41467-020-14309-wSuper-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamicsJulia Ast0Anastasia Arvaniti1Nicholas H. F. Fine2Daniela Nasteska3Fiona B. Ashford4Zania Stamataki5Zsombor Koszegi6Andrea Bacon7Ben J. Jones8Maria A. Lucey9Shugo Sasaki10Daniel I. Brierley11Benoit Hastoy12Alejandra Tomas13Giuseppe D’Agostino14Frank Reimann15Francis C. Lynn16Christopher A. Reissaus17Amelia K. Linnemann18Elisa D’Este19Davide Calebiro20Stefan Trapp21Kai Johnsson22Tom Podewin23Johannes Broichhagen24David J. Hodson25Institute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of BirminghamInstitute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of BirminghamInstitute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of BirminghamInstitute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of BirminghamInstitute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of BirminghamCentre for Liver Research, College of Medical and Dental Sciences, Institute for Immunology and Immunotherapy, University of BirminghamInstitute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of BirminghamGenome Editing Facility, Technology Hub, University of BirminghamDivision of Diabetes, Endocrinology and Metabolism, Section of Investigative Medicine, Imperial College LondonDivision of Diabetes, Endocrinology and Metabolism, Section of Investigative Medicine, Imperial College LondonDiabetes Research Group, BC Children’s Hospital Research Institute, Vancouver, BC, Canada; Department of Surgery, University of British ColumbiaCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College LondonOxford Centre for Diabetes, Endocrinology & Metabolism, University of OxfordDivision of Diabetes, Endocrinology and Metabolism, Section of Cell Biology and Functional Genomics, Imperial College LondonFaculty of Biology, Medicine and Health, University of ManchesterWellcome Trust-MRC Institute of Metabolic Science, University of CambridgeDiabetes Research Group, BC Children’s Hospital Research Institute, Vancouver, BC, Canada; Department of Surgery, University of British ColumbiaDepartment of Pediatrics, Indiana University School of MedicineDepartment of Pediatrics, Indiana University School of MedicineOptical Microscopy Facility, Max Planck Institute for Medical ResearchInstitute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of BirminghamCentre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College LondonDepartment of Chemical Biology, Max Planck Institute for Medical ResearchDepartment of Chemical Biology, Max Planck Institute for Medical ResearchDepartment of Chemical Biology, Max Planck Institute for Medical ResearchInstitute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of BirminghamGlucagon-like peptide-1 receptor is an important regulator of appetite and glucose homeostasis. Here the authors describe super-resolution microscopy and in vivo imaging compatible fluorescent probes, which reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics in islets and brain.https://doi.org/10.1038/s41467-020-14309-w |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Julia Ast Anastasia Arvaniti Nicholas H. F. Fine Daniela Nasteska Fiona B. Ashford Zania Stamataki Zsombor Koszegi Andrea Bacon Ben J. Jones Maria A. Lucey Shugo Sasaki Daniel I. Brierley Benoit Hastoy Alejandra Tomas Giuseppe D’Agostino Frank Reimann Francis C. Lynn Christopher A. Reissaus Amelia K. Linnemann Elisa D’Este Davide Calebiro Stefan Trapp Kai Johnsson Tom Podewin Johannes Broichhagen David J. Hodson |
| spellingShingle |
Julia Ast Anastasia Arvaniti Nicholas H. F. Fine Daniela Nasteska Fiona B. Ashford Zania Stamataki Zsombor Koszegi Andrea Bacon Ben J. Jones Maria A. Lucey Shugo Sasaki Daniel I. Brierley Benoit Hastoy Alejandra Tomas Giuseppe D’Agostino Frank Reimann Francis C. Lynn Christopher A. Reissaus Amelia K. Linnemann Elisa D’Este Davide Calebiro Stefan Trapp Kai Johnsson Tom Podewin Johannes Broichhagen David J. Hodson Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics Nature Communications |
| author_facet |
Julia Ast Anastasia Arvaniti Nicholas H. F. Fine Daniela Nasteska Fiona B. Ashford Zania Stamataki Zsombor Koszegi Andrea Bacon Ben J. Jones Maria A. Lucey Shugo Sasaki Daniel I. Brierley Benoit Hastoy Alejandra Tomas Giuseppe D’Agostino Frank Reimann Francis C. Lynn Christopher A. Reissaus Amelia K. Linnemann Elisa D’Este Davide Calebiro Stefan Trapp Kai Johnsson Tom Podewin Johannes Broichhagen David J. Hodson |
| author_sort |
Julia Ast |
| title |
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics |
| title_short |
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics |
| title_full |
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics |
| title_fullStr |
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics |
| title_full_unstemmed |
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics |
| title_sort |
super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-01-01 |
| description |
Glucagon-like peptide-1 receptor is an important regulator of appetite and glucose homeostasis. Here the authors describe super-resolution microscopy and in vivo imaging compatible fluorescent probes, which reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics in islets and brain. |
| url |
https://doi.org/10.1038/s41467-020-14309-w |
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