Preparation, Characterization and Wound Healing Effects of New Membranes Based on Chitosan, Hyaluronic Acid and Arginine Derivatives
New membranes based on chitosan and chitosan-hyaluronic acid containing new arginine derivatives with thiazolidine-4-one scaffold have been prepared using the ionic cross-linking method. The presence of the arginine derivatives with thiazolidine-4-one scaffold into the polymer matrix was proved by F...
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doaj-1befdf4d183f4e2cacbdc0a3a4e157d82020-11-24T23:11:30ZengMDPI AGPolymers2073-43602018-06-0110660710.3390/polym10060607polym10060607Preparation, Characterization and Wound Healing Effects of New Membranes Based on Chitosan, Hyaluronic Acid and Arginine DerivativesAndreea-Teodora Iacob0Maria Drăgan1Nicolae Ghețu2Dragoș Pieptu3Cornelia Vasile4Frédéric Buron5Sylvain Routier6Simona Elena Giusca7Irina-Draga Caruntu8Lenuța Profire9Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, Iasi 700115, RomaniaDepartment of Pharmaceutical Biotechnologies and Drug Industry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, Iasi 700115, RomaniaDepartment of Plastic Surgery, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, Iasi 700115, RomaniaDepartment of Plastic Surgery, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, Iasi 700115, RomaniaDepartment of Physical Chemistry of Polymers, “Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore GhicaVoda Alley, Iasi 700487, RomaniaInstitut de Chimie Organique et Analytique (ICOA), Univ Orleans, UMR CNRS 7311, F-45067 Orléans, FranceInstitut de Chimie Organique et Analytique (ICOA), Univ Orleans, UMR CNRS 7311, F-45067 Orléans, FranceDepartment of Morphofunctional Sciences, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, Iasi 700115, RomaniaDepartment of Morphofunctional Sciences, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, Iasi 700115, RomaniaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, Iasi 700115, RomaniaNew membranes based on chitosan and chitosan-hyaluronic acid containing new arginine derivatives with thiazolidine-4-one scaffold have been prepared using the ionic cross-linking method. The presence of the arginine derivatives with thiazolidine-4-one scaffold into the polymer matrix was proved by Fourier-transform infrared spectroscopy (FT-IR). The scanning electron microscopy (SEM) revealed a micro-porous structure that is an important characteristic for the treatment of burns, favoring the exudate absorption, the rate of colonization, the cell structure, and the angiogenesis process. The developed polymeric membranes also showed good swelling degree, improved hydrophilicity, and biocompatibility in terms of surface free energy components, which supports their application for tissue regeneration. Moreover, the chitosan-arginine derivatives (CS-6h, CS-6i) and chitosan-hyaluronic acid-arginine derivative (CS-HA-6h) membranes showed good healing effects on the burn wound model induced to rats. For these membranes a complete reepithelialization was observed after 15 days of the experiment, which supports a faster healing process.http://www.mdpi.com/2073-4360/10/6/607chitosanhyaluronic acidarginine derivativeswound dressing |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andreea-Teodora Iacob Maria Drăgan Nicolae Ghețu Dragoș Pieptu Cornelia Vasile Frédéric Buron Sylvain Routier Simona Elena Giusca Irina-Draga Caruntu Lenuța Profire |
spellingShingle |
Andreea-Teodora Iacob Maria Drăgan Nicolae Ghețu Dragoș Pieptu Cornelia Vasile Frédéric Buron Sylvain Routier Simona Elena Giusca Irina-Draga Caruntu Lenuța Profire Preparation, Characterization and Wound Healing Effects of New Membranes Based on Chitosan, Hyaluronic Acid and Arginine Derivatives Polymers chitosan hyaluronic acid arginine derivatives wound dressing |
author_facet |
Andreea-Teodora Iacob Maria Drăgan Nicolae Ghețu Dragoș Pieptu Cornelia Vasile Frédéric Buron Sylvain Routier Simona Elena Giusca Irina-Draga Caruntu Lenuța Profire |
author_sort |
Andreea-Teodora Iacob |
title |
Preparation, Characterization and Wound Healing Effects of New Membranes Based on Chitosan, Hyaluronic Acid and Arginine Derivatives |
title_short |
Preparation, Characterization and Wound Healing Effects of New Membranes Based on Chitosan, Hyaluronic Acid and Arginine Derivatives |
title_full |
Preparation, Characterization and Wound Healing Effects of New Membranes Based on Chitosan, Hyaluronic Acid and Arginine Derivatives |
title_fullStr |
Preparation, Characterization and Wound Healing Effects of New Membranes Based on Chitosan, Hyaluronic Acid and Arginine Derivatives |
title_full_unstemmed |
Preparation, Characterization and Wound Healing Effects of New Membranes Based on Chitosan, Hyaluronic Acid and Arginine Derivatives |
title_sort |
preparation, characterization and wound healing effects of new membranes based on chitosan, hyaluronic acid and arginine derivatives |
publisher |
MDPI AG |
series |
Polymers |
issn |
2073-4360 |
publishDate |
2018-06-01 |
description |
New membranes based on chitosan and chitosan-hyaluronic acid containing new arginine derivatives with thiazolidine-4-one scaffold have been prepared using the ionic cross-linking method. The presence of the arginine derivatives with thiazolidine-4-one scaffold into the polymer matrix was proved by Fourier-transform infrared spectroscopy (FT-IR). The scanning electron microscopy (SEM) revealed a micro-porous structure that is an important characteristic for the treatment of burns, favoring the exudate absorption, the rate of colonization, the cell structure, and the angiogenesis process. The developed polymeric membranes also showed good swelling degree, improved hydrophilicity, and biocompatibility in terms of surface free energy components, which supports their application for tissue regeneration. Moreover, the chitosan-arginine derivatives (CS-6h, CS-6i) and chitosan-hyaluronic acid-arginine derivative (CS-HA-6h) membranes showed good healing effects on the burn wound model induced to rats. For these membranes a complete reepithelialization was observed after 15 days of the experiment, which supports a faster healing process. |
topic |
chitosan hyaluronic acid arginine derivatives wound dressing |
url |
http://www.mdpi.com/2073-4360/10/6/607 |
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