Insight into temperature dependence of GTPase activity in human guanylate binding protein-1.

Interferon-γ induced human guanylate binding protein-1(hGBP1) belongs to a family of dynamin related large GTPases. Unlike all other GTPases, hGBP1 hydrolyzes GTP to a mixture of GDP and GMP with GMP being the major product at 37°C but GDP became significant when the hydrolysis reaction was carried...

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Bibliographic Details
Main Authors: Anjana Rani, Esha Pandita, Safikur Rahman, Shashank Deep, Apurba Kumar Sau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3394710?pdf=render

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