Myasthenia Gravis—An Analysis of Multimodal Evoked Potentials
Introduction: The aim of this study is a comprehensive analysis of the parameters of exogenous evoked potentials (visual, brainstem auditory, and somatosensory) in patients with myasthenia gravis (MG), a prototype of both neuromuscular junction disease and autoimmune disease. The study also seeks to...
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doaj-1bf3e78985dc4b26b61f4df39b96636e2021-08-26T13:34:41ZengMDPI AGBrain Sciences2076-34252021-08-01111057105710.3390/brainsci11081057Myasthenia Gravis—An Analysis of Multimodal Evoked PotentialsEdyta Dziadkowiak0Marta Waliszewska-Prosół1Małgorzata Wieczorek2Joanna Bladowska3Sławomir Budrewicz4Maria Ejma5Department of Neurology, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Neurology, Wroclaw Medical University, 50-556 Wroclaw, PolandFaculty of Earth Sciences and Environmental Management, University of Wroclaw, 50-137 Wroclaw, PolandDepartment of General Radiology, Interventional Radiology and Neuroradiology, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Neurology, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Neurology, Wroclaw Medical University, 50-556 Wroclaw, PolandIntroduction: The aim of this study is a comprehensive analysis of the parameters of exogenous evoked potentials (visual, brainstem auditory, and somatosensory) in patients with myasthenia gravis (MG), a prototype of both neuromuscular junction disease and autoimmune disease. The study also seeks to isolate electrophysiological changes that may indicate disorders within the central and/or peripheral nervous system. Methods: A total of forty-two consecutive patients with myasthenia gravis (24 women, 18 men) were included in the study. All of the patients underwent EP examination. MR images were also analyzed. Results: In the group of MG patients, the latency of P100 (113.9 ± 13.9; <i>p</i> < 0.0001) VEP, wave III (3.92 ± 0.29; <i>p</i> = 0.015), wave V (5.93 ± 0.32; <0.0001), interlatency III–V (2.00 ± 0.12; <i>p</i> < 0.0001), interlatency I–V (4.20 ± 0.28; <i>p</i> < 0.001) BAEP, and all components of SEP (N9, P10, N13, P16, N20, P22) were significantly longer. Mean wave I and V amplitude BAEP were relatively lower. Conclusions: The results of the study suggest the presence of disturbances in the bioelectric activities of the central and peripheral nervous system in MG patients.https://www.mdpi.com/2076-3425/11/8/1057myasthenia gravisvisual evoked potentialsbrainstem auditory evoked potentialssomatosensory evoked potentials |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Edyta Dziadkowiak Marta Waliszewska-Prosół Małgorzata Wieczorek Joanna Bladowska Sławomir Budrewicz Maria Ejma |
spellingShingle |
Edyta Dziadkowiak Marta Waliszewska-Prosół Małgorzata Wieczorek Joanna Bladowska Sławomir Budrewicz Maria Ejma Myasthenia Gravis—An Analysis of Multimodal Evoked Potentials Brain Sciences myasthenia gravis visual evoked potentials brainstem auditory evoked potentials somatosensory evoked potentials |
author_facet |
Edyta Dziadkowiak Marta Waliszewska-Prosół Małgorzata Wieczorek Joanna Bladowska Sławomir Budrewicz Maria Ejma |
author_sort |
Edyta Dziadkowiak |
title |
Myasthenia Gravis—An Analysis of Multimodal Evoked Potentials |
title_short |
Myasthenia Gravis—An Analysis of Multimodal Evoked Potentials |
title_full |
Myasthenia Gravis—An Analysis of Multimodal Evoked Potentials |
title_fullStr |
Myasthenia Gravis—An Analysis of Multimodal Evoked Potentials |
title_full_unstemmed |
Myasthenia Gravis—An Analysis of Multimodal Evoked Potentials |
title_sort |
myasthenia gravis—an analysis of multimodal evoked potentials |
publisher |
MDPI AG |
series |
Brain Sciences |
issn |
2076-3425 |
publishDate |
2021-08-01 |
description |
Introduction: The aim of this study is a comprehensive analysis of the parameters of exogenous evoked potentials (visual, brainstem auditory, and somatosensory) in patients with myasthenia gravis (MG), a prototype of both neuromuscular junction disease and autoimmune disease. The study also seeks to isolate electrophysiological changes that may indicate disorders within the central and/or peripheral nervous system. Methods: A total of forty-two consecutive patients with myasthenia gravis (24 women, 18 men) were included in the study. All of the patients underwent EP examination. MR images were also analyzed. Results: In the group of MG patients, the latency of P100 (113.9 ± 13.9; <i>p</i> < 0.0001) VEP, wave III (3.92 ± 0.29; <i>p</i> = 0.015), wave V (5.93 ± 0.32; <0.0001), interlatency III–V (2.00 ± 0.12; <i>p</i> < 0.0001), interlatency I–V (4.20 ± 0.28; <i>p</i> < 0.001) BAEP, and all components of SEP (N9, P10, N13, P16, N20, P22) were significantly longer. Mean wave I and V amplitude BAEP were relatively lower. Conclusions: The results of the study suggest the presence of disturbances in the bioelectric activities of the central and peripheral nervous system in MG patients. |
topic |
myasthenia gravis visual evoked potentials brainstem auditory evoked potentials somatosensory evoked potentials |
url |
https://www.mdpi.com/2076-3425/11/8/1057 |
work_keys_str_mv |
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