Fitness Cost of Litomosoides sigmodontis Filarial Infection in Mite Vectors; Implications of Infected Haematophagous Arthropod Excretory Products in Host-Vector Interactions
Filariae are a leading cause of infections which are responsible for serious dermatological, ocular, and vascular lesions. Infective third stage larvae (L3) are transmitted through the bite of a haematophagous vector. Litomosoides sigmodontis is a well-established model of filariasis in the mouse, w...
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doaj-1bf57b1c0d2b4cb4ac43ea6f2dc7cac32020-11-24T23:55:32ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/584105584105Fitness Cost of Litomosoides sigmodontis Filarial Infection in Mite Vectors; Implications of Infected Haematophagous Arthropod Excretory Products in Host-Vector InteractionsAdélaïde Nieguitsila0Roger Frutos1Catherine Moulia2Nathaly Lhermitte-Vallarino3Odile Bain4Laurent Gavotte5Coralie Martin6UMR 7245 MCAM MNHN CNRS, Muséum National d’Histoire Naturelle, 61 rue Buffon, CP52, 75231 Paris Cedex 05, FranceUMR 5236 Centre d'Études d'Agents Pathogènes et Biotechnologies pour la Santé (CPBS), 34095 Montpellier, FranceUMR 5554 ISEM CNRS, Université Montpellier 2, Place Eugène Bataillon, 34095 Montpellier, FranceUMR 7245 MCAM MNHN CNRS, Muséum National d’Histoire Naturelle, 61 rue Buffon, CP52, 75231 Paris Cedex 05, FranceUMR 7245 MCAM MNHN CNRS, Muséum National d’Histoire Naturelle, 61 rue Buffon, CP52, 75231 Paris Cedex 05, FranceUMR 5554 ISEM CNRS, Université Montpellier 2, Place Eugène Bataillon, 34095 Montpellier, FranceUMR 7245 MCAM MNHN CNRS, Muséum National d’Histoire Naturelle, 61 rue Buffon, CP52, 75231 Paris Cedex 05, FranceFilariae are a leading cause of infections which are responsible for serious dermatological, ocular, and vascular lesions. Infective third stage larvae (L3) are transmitted through the bite of a haematophagous vector. Litomosoides sigmodontis is a well-established model of filariasis in the mouse, with the vector being the mite Ornithonyssus bacoti. The aim of the study was to analyse the filarial infection in mites to determine the consequences of filarial infection in the blood-feeding and the reproduction of mites as well as in the regulation of vector-induced inflammation in the mouse skin. Firstly, L3 are unevenly distributed throughout the host population and the majority of the population harbours a moderate infection (1 to 6 L3). Filarial infection does not significantly affect the probing delay for blood feeding. The number of released protonymphs is lower in infected mites but is not correlated with the L3 burden. Finally, induced excreted proteins from infected mites but not from uninfected mites stimulate TNF-α and the neutrophil-chemoattractant KC production by antigen-presenting cells (APCs). Altogether, these results describe the modification of the mite behavior under filarial infection and suggest that the immunomodulatory capacity of the mite may be modified by the presence of the parasite, hindering its defensive ability towards the vertebrate host.http://dx.doi.org/10.1155/2013/584105 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Adélaïde Nieguitsila Roger Frutos Catherine Moulia Nathaly Lhermitte-Vallarino Odile Bain Laurent Gavotte Coralie Martin |
spellingShingle |
Adélaïde Nieguitsila Roger Frutos Catherine Moulia Nathaly Lhermitte-Vallarino Odile Bain Laurent Gavotte Coralie Martin Fitness Cost of Litomosoides sigmodontis Filarial Infection in Mite Vectors; Implications of Infected Haematophagous Arthropod Excretory Products in Host-Vector Interactions BioMed Research International |
author_facet |
Adélaïde Nieguitsila Roger Frutos Catherine Moulia Nathaly Lhermitte-Vallarino Odile Bain Laurent Gavotte Coralie Martin |
author_sort |
Adélaïde Nieguitsila |
title |
Fitness Cost of Litomosoides sigmodontis Filarial Infection in Mite Vectors; Implications of Infected Haematophagous Arthropod Excretory Products in Host-Vector Interactions |
title_short |
Fitness Cost of Litomosoides sigmodontis Filarial Infection in Mite Vectors; Implications of Infected Haematophagous Arthropod Excretory Products in Host-Vector Interactions |
title_full |
Fitness Cost of Litomosoides sigmodontis Filarial Infection in Mite Vectors; Implications of Infected Haematophagous Arthropod Excretory Products in Host-Vector Interactions |
title_fullStr |
Fitness Cost of Litomosoides sigmodontis Filarial Infection in Mite Vectors; Implications of Infected Haematophagous Arthropod Excretory Products in Host-Vector Interactions |
title_full_unstemmed |
Fitness Cost of Litomosoides sigmodontis Filarial Infection in Mite Vectors; Implications of Infected Haematophagous Arthropod Excretory Products in Host-Vector Interactions |
title_sort |
fitness cost of litomosoides sigmodontis filarial infection in mite vectors; implications of infected haematophagous arthropod excretory products in host-vector interactions |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2013-01-01 |
description |
Filariae are a leading cause of infections which are responsible for serious dermatological, ocular, and vascular lesions. Infective third stage larvae (L3) are transmitted through the bite of a haematophagous vector. Litomosoides sigmodontis is a well-established model of filariasis in the mouse, with the vector being the mite Ornithonyssus bacoti. The aim of the study was to analyse the filarial infection in mites to determine the consequences of filarial infection in the blood-feeding and the reproduction of mites as well as in the regulation of vector-induced inflammation in the mouse skin. Firstly, L3 are unevenly distributed throughout the host population and the majority of the population harbours a moderate infection (1 to 6 L3). Filarial infection does not significantly affect the probing delay for blood feeding. The number of released protonymphs is lower in infected mites but is not correlated with the L3 burden. Finally, induced excreted proteins from infected mites but not from uninfected mites stimulate TNF-α and the neutrophil-chemoattractant KC production by antigen-presenting cells (APCs). Altogether, these results describe the modification of the mite behavior under filarial infection and suggest that the immunomodulatory capacity of the mite may be modified by the presence of the parasite, hindering its defensive ability towards the vertebrate host. |
url |
http://dx.doi.org/10.1155/2013/584105 |
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