Hepcidin and Iron Deficiency in Women One Year after Sleeve Gastrectomy: A Prospective Cohort Study
Iron deficiency with or without anemia, needing continuous iron supplementation, is very common in obese patients, particularly those requiring bariatric surgery. The aim of this study was to address the impact of weight loss on the rescue of iron balance in patients who underwent sleeve gastrectomy...
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doaj-1bfcae04a000427a856dac40e1b610f32021-08-26T14:09:53ZengMDPI AGNutrients2072-66432021-07-01132516251610.3390/nu13082516Hepcidin and Iron Deficiency in Women One Year after Sleeve Gastrectomy: A Prospective Cohort StudyThibaud Lefebvre0Muriel Coupaye1Marina Esposito-Farèse2Nathalie Gault3Neila Talbi4Caroline Quintin5Caroline Schmitt6Soumeya Bekri7André Bado8Hervé Puy9Simon Msika10Carole Brasse-Lagnel11Zoubida Karim12Centre de Recherche sur l‘Inflammation, Universite de Paris, INSERM, CNRS, 75018 Paris, FranceCentre de Recherche sur l‘Inflammation, Universite de Paris, INSERM, CNRS, 75018 Paris, FranceINSERM CIC-EC 1425, Hôpital Bichat, 75018 Paris, FranceINSERM CIC-EC 1425, Hôpital Bichat, 75018 Paris, FranceCentre de Recherche sur l‘Inflammation, Universite de Paris, INSERM, CNRS, 75018 Paris, FranceUnité de Recherche Clinique, Hôpital Bichat, AP-HP, Nord-Université de Paris, 75018 Paris, FranceCentre de Recherche sur l‘Inflammation, Universite de Paris, INSERM, CNRS, 75018 Paris, FranceDepartment of Metabolic Biochemistry, Rouen University Hospital, 76000 Rouen, FranceCentre de Recherche sur l‘Inflammation, Universite de Paris, INSERM, CNRS, 75018 Paris, FranceCentre de Recherche sur l‘Inflammation, Universite de Paris, INSERM, CNRS, 75018 Paris, FranceCentre de Recherche sur l‘Inflammation, Universite de Paris, INSERM, CNRS, 75018 Paris, FranceUNIROUEN, INSERM and Rouen University Hospital, Normandy Centre for Genomic and Personalized Medicine, Normandie University, 76000 Rouen, FranceCentre de Recherche sur l‘Inflammation, Universite de Paris, INSERM, CNRS, 75018 Paris, FranceIron deficiency with or without anemia, needing continuous iron supplementation, is very common in obese patients, particularly those requiring bariatric surgery. The aim of this study was to address the impact of weight loss on the rescue of iron balance in patients who underwent sleeve gastrectomy (SG), a procedure that preserves the duodenum, the main site of iron absorption. The cohort included 88 obese women; sampling of blood and duodenal biopsies of 35 patients were performed before and one year after SG. An analysis of the 35 patients consisted in evaluating iron homeostasis including hepcidin, markers of erythroid iron deficiency (soluble transferrin receptor (sTfR) and erythrocyte protoporphyrin (PPIX)), expression of duodenal iron transporters (DMT1 and ferroportin) and inflammatory markers. After surgery, sTfR and PPIX were decreased. Serum hepcidin levels were increased despite the significant reduction in inflammation. DMT1 abundance was negatively correlated with higher level of serum hepcidin. Ferroportin abundance was not modified. This study shed a new light in effective iron recovery pathways after SG involving suppression of inflammation, improvement of iron absorption, iron supply and efficiency of erythropoiesis, and finally beneficial control of iron homeostasis by hepcidin. Thus, recommendations for iron supplementation of patients after SG should take into account these new parameters of iron status assessment.https://www.mdpi.com/2072-6643/13/8/2516iron deficiencyobesitysleeve gastrectomyhepcidiniron metabolisminflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thibaud Lefebvre Muriel Coupaye Marina Esposito-Farèse Nathalie Gault Neila Talbi Caroline Quintin Caroline Schmitt Soumeya Bekri André Bado Hervé Puy Simon Msika Carole Brasse-Lagnel Zoubida Karim |
spellingShingle |
Thibaud Lefebvre Muriel Coupaye Marina Esposito-Farèse Nathalie Gault Neila Talbi Caroline Quintin Caroline Schmitt Soumeya Bekri André Bado Hervé Puy Simon Msika Carole Brasse-Lagnel Zoubida Karim Hepcidin and Iron Deficiency in Women One Year after Sleeve Gastrectomy: A Prospective Cohort Study Nutrients iron deficiency obesity sleeve gastrectomy hepcidin iron metabolism inflammation |
author_facet |
Thibaud Lefebvre Muriel Coupaye Marina Esposito-Farèse Nathalie Gault Neila Talbi Caroline Quintin Caroline Schmitt Soumeya Bekri André Bado Hervé Puy Simon Msika Carole Brasse-Lagnel Zoubida Karim |
author_sort |
Thibaud Lefebvre |
title |
Hepcidin and Iron Deficiency in Women One Year after Sleeve Gastrectomy: A Prospective Cohort Study |
title_short |
Hepcidin and Iron Deficiency in Women One Year after Sleeve Gastrectomy: A Prospective Cohort Study |
title_full |
Hepcidin and Iron Deficiency in Women One Year after Sleeve Gastrectomy: A Prospective Cohort Study |
title_fullStr |
Hepcidin and Iron Deficiency in Women One Year after Sleeve Gastrectomy: A Prospective Cohort Study |
title_full_unstemmed |
Hepcidin and Iron Deficiency in Women One Year after Sleeve Gastrectomy: A Prospective Cohort Study |
title_sort |
hepcidin and iron deficiency in women one year after sleeve gastrectomy: a prospective cohort study |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-07-01 |
description |
Iron deficiency with or without anemia, needing continuous iron supplementation, is very common in obese patients, particularly those requiring bariatric surgery. The aim of this study was to address the impact of weight loss on the rescue of iron balance in patients who underwent sleeve gastrectomy (SG), a procedure that preserves the duodenum, the main site of iron absorption. The cohort included 88 obese women; sampling of blood and duodenal biopsies of 35 patients were performed before and one year after SG. An analysis of the 35 patients consisted in evaluating iron homeostasis including hepcidin, markers of erythroid iron deficiency (soluble transferrin receptor (sTfR) and erythrocyte protoporphyrin (PPIX)), expression of duodenal iron transporters (DMT1 and ferroportin) and inflammatory markers. After surgery, sTfR and PPIX were decreased. Serum hepcidin levels were increased despite the significant reduction in inflammation. DMT1 abundance was negatively correlated with higher level of serum hepcidin. Ferroportin abundance was not modified. This study shed a new light in effective iron recovery pathways after SG involving suppression of inflammation, improvement of iron absorption, iron supply and efficiency of erythropoiesis, and finally beneficial control of iron homeostasis by hepcidin. Thus, recommendations for iron supplementation of patients after SG should take into account these new parameters of iron status assessment. |
topic |
iron deficiency obesity sleeve gastrectomy hepcidin iron metabolism inflammation |
url |
https://www.mdpi.com/2072-6643/13/8/2516 |
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