A Proposal of Remedies for Oral Diseases Caused by Candida: A Mini Review
An opportunistic pathogen, Candida is not only related to oral problems such as oral candidiasis and denture stomatitis, but also to systemic diseases such as aspiration pneumonia and fungemia. The carriage rate of Candida species in the oral cavity of individuals wearing dentures and with removable...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-07-01
|
Series: | Frontiers in Microbiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2018.01522/full |
id |
doaj-1c015ab060bd4da7ab1352bf30d354d9 |
---|---|
record_format |
Article |
spelling |
doaj-1c015ab060bd4da7ab1352bf30d354d92020-11-25T00:08:06ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2018-07-01910.3389/fmicb.2018.01522358481A Proposal of Remedies for Oral Diseases Caused by Candida: A Mini ReviewTomoko Ohshima0Tomoko Ohshima1Satoshi Ikawa2Katsuhisa Kitano3Katsuhisa Kitano4Nobuko Maeda5School of Dental Medicine, Tsurumi University, Yokohama, JapanSchool of Engineering, Osaka University, Suita, JapanTechnology Research Institute of Osaka Prefecture, Osaka, JapanSchool of Dental Medicine, Tsurumi University, Yokohama, JapanSchool of Engineering, Osaka University, Suita, JapanSchool of Dental Medicine, Tsurumi University, Yokohama, JapanAn opportunistic pathogen, Candida is not only related to oral problems such as oral candidiasis and denture stomatitis, but also to systemic diseases such as aspiration pneumonia and fungemia. The carriage rate of Candida species in the oral cavity of individuals wearing dentures and with removable orthodontic appliances, has increased. Moreover, it is one of the causal pathogens in refractory infected root canals because of its resistance to antifungal drugs in root canal therapy and poses a great challenge during the treatment of patients. This problem has led to the search for alternative strategies for the treatment and management of C. albicans infections. In this mini review, recent preventive strategies against Candida infection in the oral mucosa with natural product-derived antifungal molecules were discussed. Inhibitory strategies by introducing competitive naturally-derived antifungal peptide molecules with Candida adhesion molecules were specifically introduced. In addition, novel sterilization methods for Candida-infected root canals and tooth structures in the oral cavity were considered, with focused attention on the activities of reactive oxygen species. The possibility of application of these novel strategies in clinical treatments and daily life was also proposed.https://www.frontiersin.org/article/10.3389/fmicb.2018.01522/fullCandida attachmentbiofilm formationdenture plaqueatmospheric plasmasplasma-treated watersterilization |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tomoko Ohshima Tomoko Ohshima Satoshi Ikawa Katsuhisa Kitano Katsuhisa Kitano Nobuko Maeda |
spellingShingle |
Tomoko Ohshima Tomoko Ohshima Satoshi Ikawa Katsuhisa Kitano Katsuhisa Kitano Nobuko Maeda A Proposal of Remedies for Oral Diseases Caused by Candida: A Mini Review Frontiers in Microbiology Candida attachment biofilm formation denture plaque atmospheric plasmas plasma-treated water sterilization |
author_facet |
Tomoko Ohshima Tomoko Ohshima Satoshi Ikawa Katsuhisa Kitano Katsuhisa Kitano Nobuko Maeda |
author_sort |
Tomoko Ohshima |
title |
A Proposal of Remedies for Oral Diseases Caused by Candida: A Mini Review |
title_short |
A Proposal of Remedies for Oral Diseases Caused by Candida: A Mini Review |
title_full |
A Proposal of Remedies for Oral Diseases Caused by Candida: A Mini Review |
title_fullStr |
A Proposal of Remedies for Oral Diseases Caused by Candida: A Mini Review |
title_full_unstemmed |
A Proposal of Remedies for Oral Diseases Caused by Candida: A Mini Review |
title_sort |
proposal of remedies for oral diseases caused by candida: a mini review |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Microbiology |
issn |
1664-302X |
publishDate |
2018-07-01 |
description |
An opportunistic pathogen, Candida is not only related to oral problems such as oral candidiasis and denture stomatitis, but also to systemic diseases such as aspiration pneumonia and fungemia. The carriage rate of Candida species in the oral cavity of individuals wearing dentures and with removable orthodontic appliances, has increased. Moreover, it is one of the causal pathogens in refractory infected root canals because of its resistance to antifungal drugs in root canal therapy and poses a great challenge during the treatment of patients. This problem has led to the search for alternative strategies for the treatment and management of C. albicans infections. In this mini review, recent preventive strategies against Candida infection in the oral mucosa with natural product-derived antifungal molecules were discussed. Inhibitory strategies by introducing competitive naturally-derived antifungal peptide molecules with Candida adhesion molecules were specifically introduced. In addition, novel sterilization methods for Candida-infected root canals and tooth structures in the oral cavity were considered, with focused attention on the activities of reactive oxygen species. The possibility of application of these novel strategies in clinical treatments and daily life was also proposed. |
topic |
Candida attachment biofilm formation denture plaque atmospheric plasmas plasma-treated water sterilization |
url |
https://www.frontiersin.org/article/10.3389/fmicb.2018.01522/full |
work_keys_str_mv |
AT tomokoohshima aproposalofremediesfororaldiseasescausedbycandidaaminireview AT tomokoohshima aproposalofremediesfororaldiseasescausedbycandidaaminireview AT satoshiikawa aproposalofremediesfororaldiseasescausedbycandidaaminireview AT katsuhisakitano aproposalofremediesfororaldiseasescausedbycandidaaminireview AT katsuhisakitano aproposalofremediesfororaldiseasescausedbycandidaaminireview AT nobukomaeda aproposalofremediesfororaldiseasescausedbycandidaaminireview AT tomokoohshima proposalofremediesfororaldiseasescausedbycandidaaminireview AT tomokoohshima proposalofremediesfororaldiseasescausedbycandidaaminireview AT satoshiikawa proposalofremediesfororaldiseasescausedbycandidaaminireview AT katsuhisakitano proposalofremediesfororaldiseasescausedbycandidaaminireview AT katsuhisakitano proposalofremediesfororaldiseasescausedbycandidaaminireview AT nobukomaeda proposalofremediesfororaldiseasescausedbycandidaaminireview |
_version_ |
1725416845646757888 |