Mode of action of antimicrobial proteins, pore-forming toxins and biologically active peptides (Hypothesis)

Mode of action of antimicrobial proteins, pore-forming toxins and biologically active peptides (Hypothesis)

Antimicrobial peptides and pore-forming toxins are important effectors in innate immune defence reactions. But their mode of action, comprising the insertion into cholesterol-containing membranes is not known. Here we explore the mechanical implications of pore-formation by extracellular protein as...

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Bibliographic Details
Main Authors: O Schmidt, M M Rahman, G Ma, U Theopold, Y Sun, M Sarjan, M Fabbri, H Roberts
Format: Article
Language:English
Published: University of Modena and Reggio Emilia 2005-07-01
Series:Invertebrate Survival Journal
Subjects:
antimicrobial peptides
pore-forming toxins
peptide hormones;
endocytosis
lipophorin
cholesterol
Online Access:https://isj02.unimore.it/index.php/ISJ/article/view/109
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spelling doaj-1c04787cafa14e76bc0226e7ef98d9232020-12-02T18:52:16ZengUniversity of Modena and Reggio EmiliaInvertebrate Survival Journal1824-307X2005-07-0122Mode of action of antimicrobial proteins, pore-forming toxins and biologically active peptides (Hypothesis)O Schmidt0M M Rahman1G Ma2U Theopold3Y Sun4M Sarjan5M Fabbri6H Roberts7Insect Molecular Biology, Faculty of Sciences (Waite Campus), University of Adelaide, Glen Osmond, SA 5064, AustraliaInsect Molecular Biology, Faculty of Sciences (Waite Campus), University of Adelaide, Glen Osmond, SA 5064, AustraliaInsect Molecular Biology, Faculty of Sciences (Waite Campus), University of Adelaide, Glen Osmond, SA 5064, AustraliaDepartment of Molecular Biology and Functional Genomics, Stockholm University, S-10691 Stockholm, SwedenThe Biotechnology Research Center, Shanxi Academy of Agricultural Sciences, 64 N.Nongke, Taiyuan, Shanxi 030031, ChinaFaculty of Agriculture, University of Mataram, Lombok, IndonesiaDepartment of Experimental Oncology, European Institute of Oncology, I-20141 Milan, ItalyInsect Molecular Biology, Faculty of Sciences (Waite Campus), University of Adelaide, Glen Osmond, SA 5064, Australia Antimicrobial peptides and pore-forming toxins are important effectors in innate immune defence reactions. But their mode of action, comprising the insertion into cholesterol-containing membranes is not known. Here we explore the mechanical implications of pore-formation by extracellular protein assemblies that drive cellular uptake reactions by leverage-mediated (LM) processes, where oligomeric adhesion molecules bent membrane-receptors around ‘hinge’-like lipophorin particles. The interactions of antimicrobial peptides, pore-forming toxins and biologically active proteins with LMassemblies provide a new paradigm for the configurational specificity and sterical selectivity of biologically active peptides. https://isj02.unimore.it/index.php/ISJ/article/view/109antimicrobial peptidespore-forming toxinspeptide hormones;endocytosislipophorincholesterol
collection DOAJ
language English
format Article
sources DOAJ
author O Schmidt
M M Rahman
G Ma
U Theopold
Y Sun
M Sarjan
M Fabbri
H Roberts
spellingShingle O Schmidt
M M Rahman
G Ma
U Theopold
Y Sun
M Sarjan
M Fabbri
H Roberts
Mode of action of antimicrobial proteins, pore-forming toxins and biologically active peptides (Hypothesis)
Invertebrate Survival Journal
antimicrobial peptides
pore-forming toxins
peptide hormones;
endocytosis
lipophorin
cholesterol
author_facet O Schmidt
M M Rahman
G Ma
U Theopold
Y Sun
M Sarjan
M Fabbri
H Roberts
author_sort O Schmidt
title Mode of action of antimicrobial proteins, pore-forming toxins and biologically active peptides (Hypothesis)
title_short Mode of action of antimicrobial proteins, pore-forming toxins and biologically active peptides (Hypothesis)
title_full Mode of action of antimicrobial proteins, pore-forming toxins and biologically active peptides (Hypothesis)
title_fullStr Mode of action of antimicrobial proteins, pore-forming toxins and biologically active peptides (Hypothesis)
title_full_unstemmed Mode of action of antimicrobial proteins, pore-forming toxins and biologically active peptides (Hypothesis)
title_sort mode of action of antimicrobial proteins, pore-forming toxins and biologically active peptides (hypothesis)
publisher University of Modena and Reggio Emilia
series Invertebrate Survival Journal
issn 1824-307X
publishDate 2005-07-01
description Antimicrobial peptides and pore-forming toxins are important effectors in innate immune defence reactions. But their mode of action, comprising the insertion into cholesterol-containing membranes is not known. Here we explore the mechanical implications of pore-formation by extracellular protein assemblies that drive cellular uptake reactions by leverage-mediated (LM) processes, where oligomeric adhesion molecules bent membrane-receptors around ‘hinge’-like lipophorin particles. The interactions of antimicrobial peptides, pore-forming toxins and biologically active proteins with LMassemblies provide a new paradigm for the configurational specificity and sterical selectivity of biologically active peptides.
topic antimicrobial peptides
pore-forming toxins
peptide hormones;
endocytosis
lipophorin
cholesterol
url https://isj02.unimore.it/index.php/ISJ/article/view/109
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