Epigenetically inactivated RASSF1A as a tumor biomarker

Epigenetically inactivated RASSF1A as a tumor biomarker

RASSF1A represents one of the eight isoforms of the RASSF1 gene. RASSF1A is a tumor suppressor gene whose inactivation influences tumor initiation and development. In cancer, RASSF1A is frequently inactivated by mutations, loss of heterozygosity and, most commonly, by promoter hypermethylation. As...

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Bibliographic Details
Main Authors: Dora Raos, Monika Ulamec, Ana Katusic Bojanac, Floriana Bulic-Jakus, Davor Jezek, Nino Sincic
Format: Article
Language:English
Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2020-11-01
Series:Bosnian Journal of Basic Medical Sciences
Subjects:
RASSF1A
epigenetic alteration
DNA methylation
biomarkers
Online Access:https://www.bjbms.org/ojs/index.php/bjbms/article/view/5219

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