Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress

There have been many reports on the relationship between mitochondrial oxidative stress and various types of diseases. This review covers mitochondrial targeting photodynamic therapy and photothermal therapy as a therapeutic strategy for inducing mitochondrial oxidative stress. We also discuss other...

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Main Authors:	Yuma Yamada, Yuta Takano, Satrialdi, Jiro Abe, Mitsue Hibino, Hideyoshi Harashima
Format:	Article
Language:	English
Published:	MDPI AG 2020-01-01
Series:	Biomolecules
Subjects:	mitochondria oxidative stress photodynamic therapy cancer therapy antioxidant therapy cell therapy drug delivery system liposomes mito-porter
Online Access:	https://www.mdpi.com/2218-273X/10/1/83

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spelling	doaj-1c17da1be7064335b07fe1e3e84983f92020-11-25T02:41:18ZengMDPI AGBiomolecules2218-273X2020-01-011018310.3390/biom10010083biom10010083Therapeutic Strategies for Regulating Mitochondrial Oxidative StressYuma Yamada0Yuta Takano1Satrialdi2Jiro Abe3Mitsue Hibino4Hideyoshi Harashima5Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, JapanResearch Institute for Electronic Science, Hokkaido University, Kita-20 Nishi-10, Kita-ku, Sapporo 001-0020, JapanFaculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, JapanDepartment of Pediatrics, Graduate School of Medicine, Hokkaido University, Kita-15, Nishi 7, Kita-ku, Sapporo 060-8638, JapanFaculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, JapanFaculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, JapanThere have been many reports on the relationship between mitochondrial oxidative stress and various types of diseases. This review covers mitochondrial targeting photodynamic therapy and photothermal therapy as a therapeutic strategy for inducing mitochondrial oxidative stress. We also discuss other mitochondrial targeting phototherapeutic methods. In addition, we discuss anti-oxidant therapy by a mitochondrial drug delivery system (DDS) as a therapeutic strategy for suppressing oxidative stress. We also describe cell therapy for reducing oxidative stress in mitochondria. Finally, we discuss the possibilities and problems associated with clinical applications of mitochondrial DDS to regulate mitochondrial oxidative stress.https://www.mdpi.com/2218-273X/10/1/83mitochondriaoxidative stressphotodynamic therapycancer therapyantioxidant therapycell therapydrug delivery systemliposomesmito-porter
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yuma Yamada Yuta Takano Satrialdi Jiro Abe Mitsue Hibino Hideyoshi Harashima
spellingShingle	Yuma Yamada Yuta Takano Satrialdi Jiro Abe Mitsue Hibino Hideyoshi Harashima Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress Biomolecules mitochondria oxidative stress photodynamic therapy cancer therapy antioxidant therapy cell therapy drug delivery system liposomes mito-porter
author_facet	Yuma Yamada Yuta Takano Satrialdi Jiro Abe Mitsue Hibino Hideyoshi Harashima
author_sort	Yuma Yamada
title	Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress
title_short	Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress
title_full	Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress
title_fullStr	Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress
title_full_unstemmed	Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress
title_sort	therapeutic strategies for regulating mitochondrial oxidative stress
publisher	MDPI AG
series	Biomolecules
issn	2218-273X
publishDate	2020-01-01
description	There have been many reports on the relationship between mitochondrial oxidative stress and various types of diseases. This review covers mitochondrial targeting photodynamic therapy and photothermal therapy as a therapeutic strategy for inducing mitochondrial oxidative stress. We also discuss other mitochondrial targeting phototherapeutic methods. In addition, we discuss anti-oxidant therapy by a mitochondrial drug delivery system (DDS) as a therapeutic strategy for suppressing oxidative stress. We also describe cell therapy for reducing oxidative stress in mitochondria. Finally, we discuss the possibilities and problems associated with clinical applications of mitochondrial DDS to regulate mitochondrial oxidative stress.
topic	mitochondria oxidative stress photodynamic therapy cancer therapy antioxidant therapy cell therapy drug delivery system liposomes mito-porter
url	https://www.mdpi.com/2218-273X/10/1/83
work_keys_str_mv	AT yumayamada therapeuticstrategiesforregulatingmitochondrialoxidativestress AT yutatakano therapeuticstrategiesforregulatingmitochondrialoxidativestress AT satrialdi therapeuticstrategiesforregulatingmitochondrialoxidativestress AT jiroabe therapeuticstrategiesforregulatingmitochondrialoxidativestress AT mitsuehibino therapeuticstrategiesforregulatingmitochondrialoxidativestress AT hideyoshiharashima therapeuticstrategiesforregulatingmitochondrialoxidativestress
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Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress

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