Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort
Abstract We aimed to develop two models to estimate first AMI and stroke/TIA, respectively, in type 2 diabetes mellitus patients, by applying backward elimination to the following variables: age, sex, duration of diabetes, smoking, BMI, and use of antihyperglycemic drugs, statins, and aspirin. As ti...
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2021-07-01
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doaj-1c1b8637558d42d3b5690dd470e6c6a32021-08-01T11:26:16ZengNature Publishing GroupScientific Reports2045-23222021-07-0111111210.1038/s41598-021-94121-8Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohortM. A. Salinero-Fort0F. J. San Andrés-Rebollo1J. Cárdenas-Valladolid2M. Méndez-Bailón3R. M. Chico-Moraleja4E. Carrillo de Santa Pau5I. Jiménez-Trujillo6I. Gómez-Campelo7C. de Burgos Lunar8J. M. de Miguel-Yanes9MADIABETESFundación de Investigación e Innovación Biosanitaria de Atención PrimariaFundación de Investigación e Innovación Biosanitaria de Atención PrimariaFundación de Investigación e Innovación Biosanitaria de Atención PrimariaDepartamento de Medicina Interna, Hospital Universitario Clínico San Carlos, Facultad de Medicina, Universidad Complutense de Madrid (UCM), Instituto de Investigación Sanitaria Hospital Clínico de San Carlos (IdISSC)Hospital Central de la DefensaComputational Biology Group, Precision Nutrition and Cancer Program, IMDEA Food InstituteUnidad Docente y de Investigación en Medicina Preventiva y Salud Pública, Facultad de Ciencias de La Salud, Universidad Rey Juan CarlosInstituto de Investigación Sanitaria del Hospital Universitario la Paz (IdIPAZ)Departamento de Medicina Preventiva del Hospital Clínico de San Carlos, Instituto de Investigación Sanitaria Hospital Clínico de San Carlos (IdISSC)Departamento de Medicina Interna, Hospital General Universitario Gregorio Marañón. Facultad de Medicina, Universidad Complutense de Madrid (UCM), Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)Abstract We aimed to develop two models to estimate first AMI and stroke/TIA, respectively, in type 2 diabetes mellitus patients, by applying backward elimination to the following variables: age, sex, duration of diabetes, smoking, BMI, and use of antihyperglycemic drugs, statins, and aspirin. As time-varying covariates, we analyzed blood pressure, albuminuria, lipid profile, HbA1c, retinopathy, neuropathy, and atrial fibrillation (only in stroke/TIA model). Both models were stratified by antihypertensive drugs. We evaluated 2980 patients (52.8% women; 67.3 ± 11.2 years) with 24,159 person-years of follow-up. We recorded 114 cases of AMI and 185 cases of stroke/TIA. The factors that were independently associated with first AMI were age (≥ 75 years vs. < 75 years) (p = 0.019), higher HbA1c (> 64 mmol/mol vs. < 53 mmol/mol) (p = 0.003), HDL-cholesterol (0.90–1.81 mmol/L vs. < 0.90 mmol/L) (p = 0.002), and diastolic blood pressure (65–85 mmHg vs. < 65 mmHg) (p < 0.001). The factors that were independently associated with first stroke/TIA were age (≥ 75 years vs. < 60 years) (p < 0.001), atrial fibrillation (first year after the diagnosis vs. more than one year) (p = 0.001), glomerular filtration rate (per each 15 mL/min/1.73 m2 decrease) (p < 0.001), total cholesterol (3.88–6.46 mmol/L vs. < 3.88 mmol/L) (p < 0.001), triglycerides (per each increment of 1.13 mmol/L) (p = 0.031), albuminuria (p < 0.001), neuropathy (p = 0.01), and retinopathy (p = 0.023).https://doi.org/10.1038/s41598-021-94121-8 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M. A. Salinero-Fort F. J. San Andrés-Rebollo J. Cárdenas-Valladolid M. Méndez-Bailón R. M. Chico-Moraleja E. Carrillo de Santa Pau I. Jiménez-Trujillo I. Gómez-Campelo C. de Burgos Lunar J. M. de Miguel-Yanes MADIABETES |
spellingShingle |
M. A. Salinero-Fort F. J. San Andrés-Rebollo J. Cárdenas-Valladolid M. Méndez-Bailón R. M. Chico-Moraleja E. Carrillo de Santa Pau I. Jiménez-Trujillo I. Gómez-Campelo C. de Burgos Lunar J. M. de Miguel-Yanes MADIABETES Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort Scientific Reports |
author_facet |
M. A. Salinero-Fort F. J. San Andrés-Rebollo J. Cárdenas-Valladolid M. Méndez-Bailón R. M. Chico-Moraleja E. Carrillo de Santa Pau I. Jiménez-Trujillo I. Gómez-Campelo C. de Burgos Lunar J. M. de Miguel-Yanes MADIABETES |
author_sort |
M. A. Salinero-Fort |
title |
Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort |
title_short |
Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort |
title_full |
Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort |
title_fullStr |
Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort |
title_full_unstemmed |
Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort |
title_sort |
cardiovascular risk factors associated with acute myocardial infarction and stroke in the madiabetes cohort |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-07-01 |
description |
Abstract We aimed to develop two models to estimate first AMI and stroke/TIA, respectively, in type 2 diabetes mellitus patients, by applying backward elimination to the following variables: age, sex, duration of diabetes, smoking, BMI, and use of antihyperglycemic drugs, statins, and aspirin. As time-varying covariates, we analyzed blood pressure, albuminuria, lipid profile, HbA1c, retinopathy, neuropathy, and atrial fibrillation (only in stroke/TIA model). Both models were stratified by antihypertensive drugs. We evaluated 2980 patients (52.8% women; 67.3 ± 11.2 years) with 24,159 person-years of follow-up. We recorded 114 cases of AMI and 185 cases of stroke/TIA. The factors that were independently associated with first AMI were age (≥ 75 years vs. < 75 years) (p = 0.019), higher HbA1c (> 64 mmol/mol vs. < 53 mmol/mol) (p = 0.003), HDL-cholesterol (0.90–1.81 mmol/L vs. < 0.90 mmol/L) (p = 0.002), and diastolic blood pressure (65–85 mmHg vs. < 65 mmHg) (p < 0.001). The factors that were independently associated with first stroke/TIA were age (≥ 75 years vs. < 60 years) (p < 0.001), atrial fibrillation (first year after the diagnosis vs. more than one year) (p = 0.001), glomerular filtration rate (per each 15 mL/min/1.73 m2 decrease) (p < 0.001), total cholesterol (3.88–6.46 mmol/L vs. < 3.88 mmol/L) (p < 0.001), triglycerides (per each increment of 1.13 mmol/L) (p = 0.031), albuminuria (p < 0.001), neuropathy (p = 0.01), and retinopathy (p = 0.023). |
url |
https://doi.org/10.1038/s41598-021-94121-8 |
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