Closed-loop, multichannel experimentation using the open-source NeuroRighter electrophysiology platform
Single neuron feedback control techniques, such as voltage clamp and dynamic clamp, have enabled numerous advances in our understanding of ion channels, electrochemical signaling, and neural dynamics. Although commercially available multichannel recording and stimulation systems are commonly used fo...
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doaj-1c1c4f1bcba9410cbe615da63891078d2020-11-24T22:05:54ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102013-01-01610.3389/fncir.2012.0009832539Closed-loop, multichannel experimentation using the open-source NeuroRighter electrophysiology platformJonathan Paul Newman0Riley eZeller-Townson1Ming-fai eFong2Ming-fai eFong3Sharanya eArcot Desai4Sharanya eArcot Desai5Robert E Gross6Robert E Gross7Steve M Potter8Georgia Institute of Technology and Emory University School of MedicineGeorgia Institute of Technology and Emory University School of MedicineGeorgia Institute of Technology and Emory University School of MedicineEmory University School of MedicineGeorgia Institute of Technology and Emory University School of MedicineEmory University School of MedicineGeorgia Institute of Technology and Emory University School of MedicineEmory University School of MedicineGeorgia Institute of Technology and Emory University School of MedicineSingle neuron feedback control techniques, such as voltage clamp and dynamic clamp, have enabled numerous advances in our understanding of ion channels, electrochemical signaling, and neural dynamics. Although commercially available multichannel recording and stimulation systems are commonly used for studying neural processing at the network level, they provide little native support for real-time feedback. We developed the open-source NeuroRighter multichannel electrophysiology hardware and software platform for closed-loop multichannel control with a focus on accessibility and low cost. NeuroRighter allows 64 channels of stimulation and recording for around US $10,000, along with the ability to integrate with other software and hardware. Here, we present substantial enhancements to the NeuroRighter platform, including a redesigned desktop application, a new stimulation subsystem allowing arbitrary stimulation patterns, low-latency data servers for accessing data streams, and a new application programming interface (API) for creating closed-loop protocols that can be inserted into NeuroRighter as plugin programs. This greatly simplifies the design of sophisticated real-time experiments without sacrificing the power and speed of a compiled programming language. Here we present a detailed description of NeuroRighter as a stand alone application, its plugin API, and an extensive set of case studies that highlight the system's abilities for conducting closed-loop, multichannel interfacing experiments.http://journal.frontiersin.org/Journal/10.3389/fncir.2012.00098/fullElectrophysiologyReal-timemicroelectrode arrayclosed-loopopen-sourcemultichannel |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jonathan Paul Newman Riley eZeller-Townson Ming-fai eFong Ming-fai eFong Sharanya eArcot Desai Sharanya eArcot Desai Robert E Gross Robert E Gross Steve M Potter |
spellingShingle |
Jonathan Paul Newman Riley eZeller-Townson Ming-fai eFong Ming-fai eFong Sharanya eArcot Desai Sharanya eArcot Desai Robert E Gross Robert E Gross Steve M Potter Closed-loop, multichannel experimentation using the open-source NeuroRighter electrophysiology platform Frontiers in Neural Circuits Electrophysiology Real-time microelectrode array closed-loop open-source multichannel |
author_facet |
Jonathan Paul Newman Riley eZeller-Townson Ming-fai eFong Ming-fai eFong Sharanya eArcot Desai Sharanya eArcot Desai Robert E Gross Robert E Gross Steve M Potter |
author_sort |
Jonathan Paul Newman |
title |
Closed-loop, multichannel experimentation using the open-source NeuroRighter electrophysiology platform |
title_short |
Closed-loop, multichannel experimentation using the open-source NeuroRighter electrophysiology platform |
title_full |
Closed-loop, multichannel experimentation using the open-source NeuroRighter electrophysiology platform |
title_fullStr |
Closed-loop, multichannel experimentation using the open-source NeuroRighter electrophysiology platform |
title_full_unstemmed |
Closed-loop, multichannel experimentation using the open-source NeuroRighter electrophysiology platform |
title_sort |
closed-loop, multichannel experimentation using the open-source neurorighter electrophysiology platform |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neural Circuits |
issn |
1662-5110 |
publishDate |
2013-01-01 |
description |
Single neuron feedback control techniques, such as voltage clamp and dynamic clamp, have enabled numerous advances in our understanding of ion channels, electrochemical signaling, and neural dynamics. Although commercially available multichannel recording and stimulation systems are commonly used for studying neural processing at the network level, they provide little native support for real-time feedback. We developed the open-source NeuroRighter multichannel electrophysiology hardware and software platform for closed-loop multichannel control with a focus on accessibility and low cost. NeuroRighter allows 64 channels of stimulation and recording for around US $10,000, along with the ability to integrate with other software and hardware. Here, we present substantial enhancements to the NeuroRighter platform, including a redesigned desktop application, a new stimulation subsystem allowing arbitrary stimulation patterns, low-latency data servers for accessing data streams, and a new application programming interface (API) for creating closed-loop protocols that can be inserted into NeuroRighter as plugin programs. This greatly simplifies the design of sophisticated real-time experiments without sacrificing the power and speed of a compiled programming language. Here we present a detailed description of NeuroRighter as a stand alone application, its plugin API, and an extensive set of case studies that highlight the system's abilities for conducting closed-loop, multichannel interfacing experiments. |
topic |
Electrophysiology Real-time microelectrode array closed-loop open-source multichannel |
url |
http://journal.frontiersin.org/Journal/10.3389/fncir.2012.00098/full |
work_keys_str_mv |
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