Rabies infection in Kidney : A hope for treatment in the future

• Main Authors: Boonyakorn Wongsakul, Visith Sitprija
• Format: Article
• Language: English
• Published: University of Tabriz 2021-07-01
• Series: Journal of Zoonotic Diseases
• Subjects: rabies; zoonosis; kidneys; virus
• Online Access: https://jzd.tabrizu.ac.ir/article_13107_b176f28761b9beafcf358dec459a9b6f.pdf

Rabies is a serious zoonotic disease. There are currently no treatment methods to cure, and most of the infected patients die. The rabies virusinvadesthe peripheral and central nervoussystem (brain), resulting in encephalitis and organ failure. But, besides the nervous system, the rabies virus can also be found in other organs such as kidneys, valves, intestines, heart, corneas, etc., with evidence through organ transplantations. The organ recipients can receive rabies and infect themselves in many countries such as the USA, China, India, France, and Germany. It is also proven that the kidneys are the organs that actually accumulate rabies but are not directly affected by the infection. The lesion of the kidney comes from the indirect effect of rabies encephalitis itself. As some mechanisms of the body and organs consist of pathogenesis, the immune system is dodged by the infectious P-protein or they become latent in the body's dendritic cells or processes glycosylation. Undestanding which of these things makes the kidneys not to be directly damaged by rabies, could be a guideline or hope in the future studies related to rabies treatment. And is a case study that must focus on organ transplant cases as well.