Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline

Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline

Two oxovanadium(IV) complexes of [VO(msatsc)(phen)], (1) (msatsc = methoxylsalicylaldehyde thiosemicarbazone, phen = phenanthroline) and its novel derivative [VO (4-chlorosatsc)(phen)], (2) (4-chlorosatsc = 4-chlorosalicylaldehyde thiosemicarbazone), have been synthesized and characterized by elemen...

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Main Authors: Yongli Zhang, Xiangsheng Wang, Wei Fang, Xiaoyan Cai, Fujiang Chu, Xiangwen Liao, Jiazheng Lu
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Bioinorganic Chemistry and Applications
Online Access:http://dx.doi.org/10.1155/2013/437134
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spelling doaj-1c205694991d4291a0969b20cd0278b52020-11-25T00:45:20ZengHindawi LimitedBioinorganic Chemistry and Applications1565-36331687-479X2013-01-01201310.1155/2013/437134437134Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and PhenanthrolineYongli Zhang0Xiangsheng Wang1Wei Fang2Xiaoyan Cai3Fujiang Chu4Xiangwen Liao5Jiazheng Lu6Department of Biology, School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, ChinaDepartment of Biology, School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, ChinaDepartment of Biology, School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, ChinaDepartment of Biology, School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, ChinaGuangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangzhou, Guangdong 510006, ChinaChemistry Department, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, ChinaChemistry Department, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, ChinaTwo oxovanadium(IV) complexes of [VO(msatsc)(phen)], (1) (msatsc = methoxylsalicylaldehyde thiosemicarbazone, phen = phenanthroline) and its novel derivative [VO (4-chlorosatsc)(phen)], (2) (4-chlorosatsc = 4-chlorosalicylaldehyde thiosemicarbazone), have been synthesized and characterized by elemental analysis, IR, ES-MS, 1H NMR, and magnetic susceptibility measurements. Their antitumor effects on BEL-7402, HUH-7, and HepG2 cells were studied by MTT assay. The antitumor biological mechanism of these two complexes was studied in BEL-7402 cells by cell cycle analysis, Hoechst 33342 staining, Annexin V-FITC/PI assay, and detection of mitochondrial membrane potential (ΔΨm). The results showed that the growth of cancer cells was inhibited significantly, and complexes 1 and 2 mainly caused in BEL-7402 cells G0/G1 cell cycle arrest and induced apoptosis. Both 1 and 2 decreased significantly the ΔΨm, causing the depolarization of the mitochondrial membrane. Complex 2 showed greater antitumor efficiency than that of complex 1.http://dx.doi.org/10.1155/2013/437134
collection DOAJ
language English
format Article
sources DOAJ
author Yongli Zhang
Xiangsheng Wang
Wei Fang
Xiaoyan Cai
Fujiang Chu
Xiangwen Liao
Jiazheng Lu
spellingShingle Yongli Zhang
Xiangsheng Wang
Wei Fang
Xiaoyan Cai
Fujiang Chu
Xiangwen Liao
Jiazheng Lu
Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline
Bioinorganic Chemistry and Applications
author_facet Yongli Zhang
Xiangsheng Wang
Wei Fang
Xiaoyan Cai
Fujiang Chu
Xiangwen Liao
Jiazheng Lu
author_sort Yongli Zhang
title Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline
title_short Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline
title_full Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline
title_fullStr Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline
title_full_unstemmed Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline
title_sort synthesis and in vitro antitumor activity of two mixed-ligand oxovanadium(iv) complexes of schiff base and phenanthroline
publisher Hindawi Limited
series Bioinorganic Chemistry and Applications
issn 1565-3633
1687-479X
publishDate 2013-01-01
description Two oxovanadium(IV) complexes of [VO(msatsc)(phen)], (1) (msatsc = methoxylsalicylaldehyde thiosemicarbazone, phen = phenanthroline) and its novel derivative [VO (4-chlorosatsc)(phen)], (2) (4-chlorosatsc = 4-chlorosalicylaldehyde thiosemicarbazone), have been synthesized and characterized by elemental analysis, IR, ES-MS, 1H NMR, and magnetic susceptibility measurements. Their antitumor effects on BEL-7402, HUH-7, and HepG2 cells were studied by MTT assay. The antitumor biological mechanism of these two complexes was studied in BEL-7402 cells by cell cycle analysis, Hoechst 33342 staining, Annexin V-FITC/PI assay, and detection of mitochondrial membrane potential (ΔΨm). The results showed that the growth of cancer cells was inhibited significantly, and complexes 1 and 2 mainly caused in BEL-7402 cells G0/G1 cell cycle arrest and induced apoptosis. Both 1 and 2 decreased significantly the ΔΨm, causing the depolarization of the mitochondrial membrane. Complex 2 showed greater antitumor efficiency than that of complex 1.
url http://dx.doi.org/10.1155/2013/437134
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AT xiangshengwang synthesisandinvitroantitumoractivityoftwomixedligandoxovanadiumivcomplexesofschiffbaseandphenanthroline
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