An overview on the potential of natural products as ureas
Ureases, enzymes that catalyze urea hydrolysis, have received considerable attention for their impact on living organisms’ health and life quality. On the one hand, the persistence of urease activity in human and animal cells can be the cause of some diseases and pathogen infections. On the other h...
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doaj-1c221372cbc449498dbaeac2148638a22020-11-24T22:50:16ZengElsevierJournal of Advanced Research2090-12322090-12242015-01-0161354410.1016/j.jare.2014.09.001An overview on the potential of natural products as ureasLuzia V. Modolo0Aline X. de Souza1Lívia P. Horta2Débora P. Araujo3Ângelo de Fátima4Departamento de Botânica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG 31270-901, BrazilDepartamento de Botânica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG 31270-901, BrazilDepartamento de Botânica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG 31270-901, BrazilDepartamento de Botânica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG 31270-901, BrazilDepartamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG 31270-901, Brazil Ureases, enzymes that catalyze urea hydrolysis, have received considerable attention for their impact on living organisms’ health and life quality. On the one hand, the persistence of urease activity in human and animal cells can be the cause of some diseases and pathogen infections. On the other hand, food production can be negatively affected by ureases of soil microbiota that, in turn, lead to losses of nitrogenous nutrients in fields supplemented with urea as fertilizer. In this context, nature has proven to be a rich resource of natural products bearing a variety of scaffolds that decrease the ureolytic activity of ureases from different organisms. Therefore, this work compiles the state-of-the-art researches focused on the potential of plant natural products (present in extracts or as pure compounds) as urease inhibitors of clinical and/or agricultural interests. Emphasis is given to ureases of Helicobacter pylori, Canavalia ensiformis and soil microbiota although the active site of this class of hydrolases is conserved among living organisms. http://www.sciencedirect.com/science/article/pii/S2090123214001088Plant natural productsUreasesHuman healthHelicobacter pyloriCanavalia ensiformisFood production |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luzia V. Modolo Aline X. de Souza Lívia P. Horta Débora P. Araujo Ângelo de Fátima |
spellingShingle |
Luzia V. Modolo Aline X. de Souza Lívia P. Horta Débora P. Araujo Ângelo de Fátima An overview on the potential of natural products as ureas Journal of Advanced Research Plant natural products Ureases Human health Helicobacter pylori Canavalia ensiformis Food production |
author_facet |
Luzia V. Modolo Aline X. de Souza Lívia P. Horta Débora P. Araujo Ângelo de Fátima |
author_sort |
Luzia V. Modolo |
title |
An overview on the potential of natural products as ureas |
title_short |
An overview on the potential of natural products as ureas |
title_full |
An overview on the potential of natural products as ureas |
title_fullStr |
An overview on the potential of natural products as ureas |
title_full_unstemmed |
An overview on the potential of natural products as ureas |
title_sort |
overview on the potential of natural products as ureas |
publisher |
Elsevier |
series |
Journal of Advanced Research |
issn |
2090-1232 2090-1224 |
publishDate |
2015-01-01 |
description |
Ureases, enzymes that catalyze urea hydrolysis, have received considerable attention for their impact on living organisms’ health and life quality. On the one hand, the persistence of urease activity in human and animal cells can be the cause of some diseases and pathogen infections. On the other hand, food production can be negatively affected by ureases of soil microbiota that, in turn, lead to losses of nitrogenous nutrients in fields supplemented with urea as fertilizer. In this context, nature has proven to be a rich resource of natural products bearing a variety of scaffolds that decrease the ureolytic activity of ureases from different organisms. Therefore, this work compiles the state-of-the-art researches focused on the potential of plant natural products (present in extracts or as pure compounds) as urease inhibitors of clinical and/or agricultural interests. Emphasis is given to ureases of Helicobacter pylori, Canavalia ensiformis and soil microbiota although the active site of this class of hydrolases is conserved among living organisms.
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topic |
Plant natural products Ureases Human health Helicobacter pylori Canavalia ensiformis Food production |
url |
http://www.sciencedirect.com/science/article/pii/S2090123214001088 |
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