New opportunities in endocrine ophthalmopathy diagnostics (review)
Endocrine ophthalmopathy (EOP) is a progressive autoimmune disease that affects soft retrobulbar tissues in thyroid gland diseases. The statistical data on this disease are presented. The review presents both generally accepted and alternative approaches to the diagnosis of EOP different stages. Det...
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Endocrinology Research Centre
2017-12-01
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doaj-1c22d7e8b95d44ee867a6b99fb17dce22021-06-02T19:26:25ZrusEndocrinology Research CentreКлиническая и экспериментальная тиреоидология1995-54722310-37872017-12-01133202810.14341/ket2017320-288388New opportunities in endocrine ophthalmopathy diagnostics (review)Elizaveta S. Taskina0Svetlana V. Charinzeva1Vladimir V. Charinzev2Dmitriy M. Serkin3Chita State Medical AcademyChita State Medical AcademyChita State Medical AcademyChita State Medical AcademyEndocrine ophthalmopathy (EOP) is a progressive autoimmune disease that affects soft retrobulbar tissues in thyroid gland diseases. The statistical data on this disease are presented. The review presents both generally accepted and alternative approaches to the diagnosis of EOP different stages. Detailed clinical symptoms, main severity and activity score classifications of EOP, the required list of physical and instrumental examinations are given. We described the diagnostic value of computed tomography, magnetic resonance imaging, optical coherence tomography, Heidelberg Retina Tomography, radioisotope studies, triplex scanning of the major vessels of the eye, the Doppler mapping method, indocyanine-green angiography, as well as the histological examination of soft retrobulbar tissues biopsy in EOP. Generally accepted diagnostic methods of EOP have their disadvantages. Therefore, nowadays the promising direction is immunological, biochemical and genetic studies of EOP activity markers. The peculiarity of these methods in EOP diagnosis is an accuracy, possibility of multiple measurements, few side effects and a relatively low cost. Further studies of key mechanisms of the development of edema, leukocyte infiltration with subsequent formation of fibrosis of extraocular muscles and retrobulbar fiber in EOP is of significance, which may improve diagnostics of clinical complicated cases and initial stages of the disease.https://cet-endojournals.ru/ket/article/viewFile/9397/7081thyroid eye diseaseendocrine ophthalmopathygraves’ ophthalmopathyextraocular musclesretrobulbar tissuediagnostics |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
Elizaveta S. Taskina Svetlana V. Charinzeva Vladimir V. Charinzev Dmitriy M. Serkin |
spellingShingle |
Elizaveta S. Taskina Svetlana V. Charinzeva Vladimir V. Charinzev Dmitriy M. Serkin New opportunities in endocrine ophthalmopathy diagnostics (review) Клиническая и экспериментальная тиреоидология thyroid eye disease endocrine ophthalmopathy graves’ ophthalmopathy extraocular muscles retrobulbar tissue diagnostics |
author_facet |
Elizaveta S. Taskina Svetlana V. Charinzeva Vladimir V. Charinzev Dmitriy M. Serkin |
author_sort |
Elizaveta S. Taskina |
title |
New opportunities in endocrine ophthalmopathy diagnostics (review) |
title_short |
New opportunities in endocrine ophthalmopathy diagnostics (review) |
title_full |
New opportunities in endocrine ophthalmopathy diagnostics (review) |
title_fullStr |
New opportunities in endocrine ophthalmopathy diagnostics (review) |
title_full_unstemmed |
New opportunities in endocrine ophthalmopathy diagnostics (review) |
title_sort |
new opportunities in endocrine ophthalmopathy diagnostics (review) |
publisher |
Endocrinology Research Centre |
series |
Клиническая и экспериментальная тиреоидология |
issn |
1995-5472 2310-3787 |
publishDate |
2017-12-01 |
description |
Endocrine ophthalmopathy (EOP) is a progressive autoimmune disease that affects soft retrobulbar tissues in thyroid gland diseases. The statistical data on this disease are presented. The review presents both generally accepted and alternative approaches to the diagnosis of EOP different stages. Detailed clinical symptoms, main severity and activity score classifications of EOP, the required list of physical and instrumental examinations are given. We described the diagnostic value of computed tomography, magnetic resonance imaging, optical coherence tomography, Heidelberg Retina Tomography, radioisotope studies, triplex scanning of the major vessels of the eye, the Doppler mapping method, indocyanine-green angiography, as well as the histological examination of soft retrobulbar tissues biopsy in EOP. Generally accepted diagnostic methods of EOP have their disadvantages. Therefore, nowadays the promising direction is immunological, biochemical and genetic studies of EOP activity markers. The peculiarity of these methods in EOP diagnosis is an accuracy, possibility of multiple measurements, few side effects and a relatively low cost. Further studies of key mechanisms of the development of edema, leukocyte infiltration with subsequent formation of fibrosis of extraocular muscles and retrobulbar fiber in EOP is of significance, which may improve diagnostics of clinical complicated cases and initial stages of the disease. |
topic |
thyroid eye disease endocrine ophthalmopathy graves’ ophthalmopathy extraocular muscles retrobulbar tissue diagnostics |
url |
https://cet-endojournals.ru/ket/article/viewFile/9397/7081 |
work_keys_str_mv |
AT elizavetastaskina newopportunitiesinendocrineophthalmopathydiagnosticsreview AT svetlanavcharinzeva newopportunitiesinendocrineophthalmopathydiagnosticsreview AT vladimirvcharinzev newopportunitiesinendocrineophthalmopathydiagnosticsreview AT dmitriymserkin newopportunitiesinendocrineophthalmopathydiagnosticsreview |
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1721401574826180608 |